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Centeno de Vero, Jeffrey,Inwoong Hwang,Santiago, Alvin L.,Doopyo Lee,Jungwon Chang,Jinhee Kim,Sarmago, Roland V.,Jong Hyun Song IEEE 2014 IEEE transactions on magnetics Vol.50 No.11
<P>We successfully grew AIrO<SUB>3</SUB> (A = Ca, Ba Sr) incorporated Bi<SUB>2</SUB> Sr<SUB>2</SUB> CaCu<SUB>2</SUB>O<SUB>8+δ</SUB> (BSCCO) films using pulsed laser deposition technique with post-growth ex situ treatment. The incorporation was accomplished by initially growing AIrO<SUB>3</SUB> iridate nanoparticles on top of a single crystal MgO (100) substrate followed by a BSCCO layer. The composite film was then partial melted at 890 °C for 15 min and annealed at 850 °C for 5 h in ambient air. In this way, we controlled the type of iridate nanoparticles, which were embedded inside the superconducting BSCCO matrix. We observed that the superconducting transition temperature T<SUB>c-zero</SUB>, activation energy U<SUB>o</SUB>, and magnetoresistance can be tuned depending on the type of iridate incorporation.</P>
Thaise Boeing,Francislaine Aparecida dos Reis Lívero,Priscila de Souza,Danielle Ayr Tavares de Almeida,Guilherme Donadel,Emerson Luiz Botelho Lourenço,Arquimedes Gasparotto Junior 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.5
The mitochondria have an important role in modulating cell cycle progression, cell survival, and apoptosis. In the adult heart, the cardiac mitochondria have a unique spatial arrangement and occupy nearly one-third the volume of a cardiomyocyte, being highly efficient for converting the products of glucose or fatty acid metabolism into adenosine triphosphate (ATP). In cardiomyocytes, the decline of mitochondrial function reduces ATP generation and increases the production of reactive oxygen species, which generates impaired heart function. This is because mitochondria play a key role in maintaining cytosolic calcium concentration and modulation of muscle contraction, as ATP is required to dissociate actin from myosin. Beyond that, mitochondria have a significant role in cardiomyocyte apoptosis because it is evident that patients who have cardiovascular diseases (CVDs) have increased mitochondrial DNA damage to the heart and aorta. Many studies have shown that natural products have mitochondria-modulating effects in cardiac diseases, determining them as potential candidates for new medicines. This review outlines the leading plant secondary metabolites and natural compounds derived from microorganisms as modulators of mitochondrial dysfunctions associated with CVDs.