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        Chemokine and Chemokine Receptor Polymorphisms in Bipolar Disorder

        Damla Tokac,Erdem Tuzun,Vuslat Yılmaz,Elif Sinem Bireller,Bedia Cakmakoglu,Cem Ismail Kucukali 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.5

        ObjectiveaaBipolar disorder (BD) is a debilitating psychiatric disease with unknown etiology. Recent studies have shown inflammation as a potential contributing factor of BD pathogenesis. However, potential associations between chemokine and chemokine receptor polymorphisms and BD have been fundamentally understudied. To identify participation of chemokines in BD pathogenesis, we examined genetic variants of several chemokine and chemokine receptor genes. MethodsaaThe study population comprised 200 patients with BD and 195 age- and sex-matched healthy controls. Genotyping of monocyte chemotactic protein 1 (MCP-1) A2518G, CCR2 V64I, CCR5 Δ32, CCR5 A55029G, stromal cell-derived factor 1 (SDF-1) 3’A, and CXCR4 C138T polymorphisms was performed using polymerase chain reaction and restriction enzyme digestion. ResultsaaWe found that CCR5-Δ32 II and CXCR4-C138T C+ genotype frequencies contributed to an increased risk for BD. However, no statistical significance could be obtained with these genotypes after Bonferroni correction. A significant asssociation was only found with MCP-1 GG and G+ genotypes, which were markedly more prevalent in patients with BD and these genotypes seemed to significantly increase the risk for BD even after Bonferroni correction. ConclusionaaOur findings indicate an association between genetic variants of certain chemokine and chemokine receptor (especially MCP-1) genes and BD. The exact mechanisms by which these variants contribute to BD pathogenesis and their clinical implications need to be further investigated.

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        Preparation of magnetic activated carbon-chitosan nanocomposite for crystal violet adsorption

        Ferda Civan Çavuşoğlu,Seher Akan,Ezgi Aleyna Arı,Ezgi Çetinkaya,Elif Çolak,Gamze Nur Daştan,Semina Deniz,Damla Erdem,Melda Köksal,Sevgi Korkmaz,Nursena Onsekiz,Betül Oruçoğlu,Didem Özkaya,Hamdi Buğra 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.11

        Magnetic, cheap and versatile adsorbents were developed for crystal violet (CV) adsorption in this study. These adsorbents are magnetic activated carbon (AC-Fe3O4) and chitosan grafted magnetic activated carbon (Chitosan- AC-Fe3O4). Fe3O4 and chitosan were also used for adsorption. X-ray diffraction (XRD), scanning electron microscopy (SEM), vibrating sample magnetometer (VSM), zeta potential analysis and Fourier transform infrared spectroscopy (FTIR) methods were used for characterization of adsorbents. Adsorption parameters for CV were investigated. Raw chitosan and Fe3O4 were also used for CV adsorption to compare the results of composites. The chosen adsorption parameters are amount of adsorbent, contact time, initial CV concentration, and temperature. The equilibrium period was observed to be very short for chitosan and Fe3O4 nanoparticles. The adsorption efficiencies of these adsorbents are very low. AC-Fe3O4 and AC-Fe3O4-Chitosan nanoparticles reached equilibrium at 80min. The all adsorbent-CV systems followed pseudo second-order kinetic model. AC-Fe3O4 and AC-Fe3O4-Chitosan composites suited non-linear Freundlich isotherm for all temperatures (298, 308 and 318 K). Regeneration of adsorbents was also investigated. 1M of acetic acid and 0.1M of NaOH solutions were tested. Acetic acid solution desorbed CV better than NaOH solution at 6 hours.

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