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- 저자 : Dajian Zhu (검색결과 3 건)
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Zhihao Zeng,Xiaowu Chen,Dajian Zhu,Zhongran Luo,Min Yang 연세대학교의과대학 2017 Yonsei medical journal Vol.58 No.4
Purpose: The microRNA-34 (miR-34) family is important in tumor regulation. This study aimed to investigate the association of circulating miR-34 family proteins with clinicopathological features and their prognostic value in triple-negative breast cancer (TNBC) patients. Materials and Methods: In this cohort study, 173 TNBC patients admitted to First People’s Hospital of Shunde from May 1, 2009 to April 30, 2013 were enrolled. Meanwhile, 75 age-matched healthy women volunteers were identified as healthy controls (HCs). We examined the expression of miR-34 family (miR-34a/b/c) proteins in plasma collected from TNBC patients before any treatmentwas performed and from age-matched HCs using qPCR methods. Results: The expressions of miR-34a/34b/34c were significantly lower in TNBC patients than in HC (p<0.001, p=0.027, p<0.001, respectively). miR-34a was correlated with tumor grade (p=0.038), lymph node positive (p=0.027), distant metastasis (p=0.004), and surgery (p=0.023); miR-34b was correlated with lymph node positivity (p=0.027); and miR-34c was correlated with tumor grade (p=0.017) and distant metastasis (p<0.001). Kaplan-Meier curve analysis displayed low expression of miR-34a as associated with worse overall survival (OS) (p=0.011), as well as miR-34c low expression (p=0.002). In addition, univariate and multivariate Cox proportional hazards regression was performed, and low expression of miR-34c (p=0.011) was found to be an independent risk factor for OS, as well as tumor grade (p=0.013), lymph node positive (p=0.050), and distant metastasis (p=0.021). Conclusion: In conclusion, this study demonstrated reduced miR-34a/c expression is highly associated with tumor progression and indicated worse prognosis. Also, miR-34c was an independent risk factor for OS in TNBC patients.
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Jian Chen,Yan Zhang,Tao Li,Dajian Zhu 한국고분자학회 2019 Macromolecular Research Vol.27 No.9
The shape of the supporters would influence the catalytic performance in Suzuki-Miyaura coupling reaction. To test the hypothesis, this study synthesized polyamides and their corresponding catalysts with different shapes by the templateassisted method using cheap and commercially available melamine and p-phthalic acid as raw materials. The samples were characterized by SEM, XPS, TEM, XRD, FT-IR, TGA and BET surface area and porosity analyzers. After detailed investigation of these polyamides with different shapes and their applications to catalytic reactions, it was established that these polyamides could be recyclable and efficient catalyst supporters towards Suzuki-Miyaura reactions. Supporters’ shape influence the TOF (turnover frequency) value of the catalysts in Suzuki-Miyaura reaction and interaction between Pd active specie and supporters in the heterogeneous catalysts. Polyamides supported Pd catalysts exhibit excellent activity, selectivity and reusability in water medium.
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Low-noise reconstruction method for coded-aperture gamma camera based on multi-layer perceptron
Rui Zhang,Xiaobin Tang,Pin Gong,Peng Wang,Cheng zhou,Xiaoxiang Zhu,Dajian Liang,Zeyu Wang 한국원자력학회 2020 Nuclear Engineering and Technology Vol.52 No.10
Accurate localization of radioactive materials is crucial in homeland security and radiological emergencies. Coded-aperture gamma camera is an interesting solution for such applications and can be developed into portable real-time imaging devices. However, traditional reconstruction methods cannot effectively deal with signal-independent noise, thereby hindering low-noise real-time imaging. In this study, a novel reconstruction method with excellent noise-suppression capability based on a multi-layer perceptron (MLP) is proposed. A coded-aperture gamma camera based on pixel detector and coded-aperture mask was constructed, and the process of radioactive source imaging was simulated. Results showed that the MLP method performs better in noise suppression than the traditional correlation analysis method. When the Co-57 source with an activity of 1 MBq was at 289 different positions within the field of view which correspond to 289 different pixels in the reconstructed image, the average contrast-to-noise ratio (CNR) obtained by the MLP method was 21.82, whereas that obtained by the correlation analysis method was 5.85. The variance in CNR of the MLP method is larger than that of correlation analysis, which means the MLP method has some instability in certain conditions.
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