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Song, Doona,Lee, Chulho,Kook, Yoon Jeong,Oh, Soo Jin,Kang, Jong Soon,Kim, Hyun-Jung,Han, Gyoonhee Elsevier 2017 European journal of medicinal chemistry Vol.126 No.-
<P><B>Abstract</B></P> <P>RUNX3, a tumor suppressor, is suppressed in various cancers by abnormal epigenetic changes. Histone deacetylases (HDACs) can deacetylate the lysine residues of RUNX3, followed by degradation via a ubiquitin-mediated pathway. Inhibition of HDAC leads to functional restoration of the RUNX3 protein by epigenetic expression and RUNX3 protein stabilization. We previously reported a series of HDAC inhibitors that restored RUNX3 function. In the present study, we introduced an alkenyl linker group to pyridine-based HDAC inhibitors to improve their potencies and chemical properties. This alkenyl linker made the compounds more rigid, facilitating a better fit than alkyl moieties to the active site of HDAC proteins. Most compounds in this series exhibited potent RUNX activities, HDAC inhibitory activities, and inhibitory activities towards the growth of human cancer cell lines. Notably, one of these derivatives, (<I>E</I>)-3-(1-cinnamyl-2-oxo-1,2-dihydropyridin-3-yl)-<I>N</I>-hydroxyacrylamide (<B>7k</B>), showed excellent properties in a microsomal stability study, in a xenograft study, and in an <I>in vivo</I> pharmacokinetic evaluation. Modulation of RUNX3 therefore results in highly potent and orally available anticancer chemotherapeutic agents.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new series of RUNX3 modulators showed improved <I>in vitro</I> biological evaluations metabolic stability profiles. </LI> <LI> Compounds exhibited a significant <I>in vivo</I> antitumor activity and pharmacokinetic profiles. </LI> <LI> Compound <B>7k</B> could be a highly potent and orally available anticancer agent. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>A new series of pyridone-core based HDAC inhibitors were synthesized for anticancer chemotherapy through RUNX3 modulation.</P> <P>[DISPLAY OMISSION]</P>
BMN(Bluetooth Mesh Networking)의 지하공간 적용성에 대한 사례 조사
이철호(Chulho Lee),최순욱(Soon-Wook Choi),강태호(Tae-Ho Kang),전진오(Jinoh Jeon),안청진(Cheongjin Ahn),송태건(Tae-Geon Song) 한국암반공학회 2019 터널과지하공간 Vol.29 No.6
IT기술의 발전에 따라 무선 네트워크 통신을 사용하여 실시간으로 지하공사 현장을 관리하는 방안이 고려되고 있다. 지하공간은 밀폐된 통신환경과 공간적인 특성으로 인해 지상에 비해 상대적으로 사용에 제한이 있다. BMN(Bluetooth Mesh Networking) 기술은 최근에 소개된 무선통신 기술로 중계기 역할을 하는 블루투스 장비로 네트워크 망을 형성하고 개별 기기를 모니터링하는 기술이다. 본 기술기사에서는 BMN 기술의 지하공간 적용성을 분석하기 위해 고려해야 할 부분과 현재 국내외에서 개발되고 있는 무선통신 모니터링 시스템 사례 및 연구에 대해 조사하였다. 그리고 지하공간 적용을 목표로 개발이 진행되고 있는 국내 BMN 기술에 대해서도 소개하고 있다. As the development of IT technology, the way to manage the underground construction site in real time using wireless network communication is being considered. Underground space is limited area compared to the ground site due to the enclosed communication environment and spatial characteristics. BMN (Bluetooth Mesh Networking) technology is a recently introduced wireless communication technology that bluetooth device acts as a repeater to form a networking mesh and monitor individual devices. This article examines the areas to be considered for analyzing the applicability of BMN technology to underground spaces, and the cases studies of wireless communication monitoring systems currently being developed. And the BMN technology which is being developed for the underground application is also introduced.
Choi, Eunhyun,Lee, Chulho,Cho, Misun,Seo, Jeong Jea,Yang, Jee Sun,Oh, Soo Jin,Lee, Kiho,Park, Song-Kyu,Kim, Hwan Mook,Kwon, Ho Jeong,Han, Gyoonhee American Chemical Society 2012 Journal of medicinal chemistry Vol.55 No.23
<P>Hydroxamate-based HDAC inhibitors have promising anticancer activities but metabolic instability and poor pharmacokinetics leading to poor in vivo results. QSAR and PK studies of HDAC inhibitors showed that a γ-lactam core and a modified cap group, including halo, alkyl, and alkoxy groups with various carbon chain linkers, improved HDAC inhibition and metabolic stability. The biological properties of the γ-lactam HDAC inhibitors were evaluated; the compound designated <B>8f</B> had potent anticancer activity and high oral bioavailability.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jmcmar/2012/jmcmar.2012.55.issue-23/jm3009376/production/images/medium/jm-2012-009376_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jm3009376'>ACS Electronic Supporting Info</A></P>
Temperature Dependent Octahedral Tilting Behaviors of Monoclinic and Tetragonal SrRuO3 Thin Films
이성수,서옥균,Jaemyung Kim,Chulho Song,Satoshi Hiroi,Yanna Chen,Yoshio Katsuya,Osami Sakata 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.73 No.10
We used in-situ synchrotron X-ray scattering to investigate phase transformations of octahedral tilted monoclinic SrRuO3 (MSRO) and tetragonal SRO (TSRO) thin films on SrTiO3 (STO) substrates. The octahedral tilted MSRO thin films were highly crystalline and the monoclinic distortion angle was 0.45. The phase transition temperature from the MSRO to TSRO phase occurred at approximately 200 C as a second order transition. Conversely, no phase transformations of the TSRO thin film occurred within the range from RT to 250 C. The octahedral RuO6 rotation was strongly affected by the phase transformation in the SRO thin films.
최영철(Youngchul Choi),김철호(Chulho Kim),이현채(Hyunchae Lee),서영택(Youngtaek Seo),한용운(Youngoun Han),송정일(Jungil Song) Korean Society for Precision Engineering 2012 한국정밀공학회지 Vol.29 No.6
In this study, a small wind turbine airfoil specialized for national wind condition was designed in order to develop the furling control type HAWT. And then a flow analysis was carried out based on the blade drawing which was designed to characterize of the developed airfoil. The result of the flow analysis showed that the torque on the 3 blades was 180.23N.m. This is equivalent to an output power of 5.66kw and an output efficiency of 0.44. Then we produced and constructed a 3㎾ - furling control type HAWT by getting the system unit design technology such as the specialized furling control device. By operating this turbine, we could get 3㎾ of the rated power at a wind speed of 10.5㎧ through the ability test. Cut-in wind speed was 2㎧, generator efficiency was 92% at the rated power output. Sound power level was 87.2㏈(A). Also we observed that the output power was limited to 10.5㎧ with furling system operation.
Intraoperative Real-Time Localization of Normal Parathyroid Glands With Autofluorescence Imaging
Kim, Sung Won,Song, Seo Hyun,Lee, Hyoung Shin,Noh, Woong Jae,Oak, Chulho,Ahn, Yeh-Chan,Lee, Kang Dae Issued for the Endocrine Society by the Williams & 2016 The Journal of clinical endocrinology & metabolism Vol.101 No.12
<P>Conclusions: This method showed the precise localization of the parathyroid glands and demonstrated their relation to background tissue. We believe that this simple, nonexogenous dye technique of anatomical guidance can aid surgeons to preserve parathyroid glands during thyroidectomy.</P>