http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kim, Yong Kyun,Kim, Su-Hyun,Kim, Hyung Wook,Kim, Young Ok,Jin, Dong Chan,Song, Ho Chul,Choi, Euy Jin,Kim, Yong-Lim,Kim, Yon-Su,Kang, Shin-Wook,Kim, Nam-Ho,Yang, Chul Woo SAGE Publications 2014 Peritoneal dialysis international Vol.34 No.4
<B>Background</B><P> Previous studies have demonstrated that increased body mass index (BMI) is associated with decreased mortality in hemodialysis (HD) patients. However, the association between BMI and survival has not been well established in patients undergoing peritoneal dialysis (PD). The aim of the study was to determine the association between BMI and mortality in the PD population using the Clinical Research Center (CRC) registry for end-stage renal disease (ESRD) cohort in Korea. </P><B>Methods</B><P> Prevalent patients with PD were selected from the CRC registry for ESRD, a prospective cohort study on dialysis patients in Korea. Patients were categorized into four groups by quartiles of BMI. Cox regression analysis was used to calculate the adjusted hazard ratio (HR) of mortality with a BMI of quartile 2 (21.4 - 23.5 kg/m<SUP>2</SUP>) as the reference. </P><B>Results</B><P> A total of 900 prevalent patients undergoing PD were included. The median follow-up period was 24 months. The multivariate Cox proportional hazard model showed that the lowest quartile of BMI was associated with higher mortality (HR 3.00,95% confidence interval (CI), 1.26 - 7.15). However, the higher quartiles of BMI were not associated with mortality compared with the reference category of BMI quartile 2 (Quartile 3: HR 1.11, 95% CI, 0.43 - 2.85, Quartile 4: H R 1.64,95% CI, 0.66 - 4.06) after adjustment for clinical variables. </P><B>Conclusions</B><P> Lower BMI was a significant risk factor for death, but increased BMI was not associated with mortality in Korean PD patients. </P>
Impact of Dialysate Calcium Concentration on Clinical Outcomes in Incident Hemodialysis Patients
Kim, Hyung Wook,Kim, Su-Hyun,Kim, Young Ok,Jin, Dong Chan,Song, Ho Chul,Choi, Euy Jin,Kim, Yong-Lim,Kim, Yon-Su,Kang, Shin-Wook,Kim, Nam-Ho,Yang, Chul Woo,Kim, Yong Kyun,Malindretos., Pavlos Williams & Wilkins Co 2015 Medicine Vol.94 No.40
<P><B>Abstract</B></P><P>The association between dialysate calcium (DCa) concentration and mortality in hemodialysis (HD) patients is controversial. In this study, we evaluated the impact of DCa concentration on mortality in incident HD patient.</P><P>Incident HD patients were selected from the Clinical Research Center registry—a prospective cohort study on dialysis patients in Korea. Patients were categorized into 3 groups according to the prescribed DCa concentration at the time of enrollment. High DCa was defined as a concentration of 3.5 mEq/L, mid-DCa as 3.0 mEq/L, and low DCa as 2.5 to 2.6 mEq/L. The primary outcome was all-cause mortality and secondary outcomes were cardiovascular or infection-related hospitalization.</P><P>A total of 1182 patients with incident HD were included. The number of patients in each group was 182 (15.4%) in high DCa group, 701 (59.3%) in the mid-DCa group, and 299 (25.3%) in the low DCa group. The median follow-up period was 16 months. The high DCa group had a significantly higher risk of all-cause mortality compared with the mid-DCa group (hazard ratio [HR] 2.23, 95% confidence interval [CI] 1.28–3.90, <I>P</I> = 0.005) and the low DCa group (HR 3.67, 95% CI 1.78–7.55, <I>P</I> < 0.001) after adjustment for clinical variables. The high DCa group was associated with higher risk of cardiovascular and infection-related hospitalization compared with the low DCa group (HR 3.25, 95% CI 1.53–6.89, <I>P</I> = 0.002; and HR 2.77, 95% CI 1.29–5.94, <I>P</I> = 0.009, respectively). Of these 1182 patients, 163 patients from each group were matched by propensity scores. In the propensity score matched analysis, the high DCa group had a significantly higher risk of all-cause mortality compared with the mid-DCa group (HR 2.52, 95% CI 1.04–6.07, <I>P</I> = 0.04) and the low DCa group (HR 4.25, 95% CI 1.64–11.03, <I>P</I> = 0.003) after adjustment for clinical variables.</P><P>Our data showed that HD using a high DCa was a significant risk factor for all-cause mortality and cardiovascular or infection-related hospitalization in incident HD patients.</P>
Kim, Taek‐,Keun,Park, Chang Sik,Jang, Jihye,Kim, Mi Ra,Na, Hee‐,Jun,Lee, Kangseung,Kim, Hyun Jung,Heo, Kyun,Yoo, Byong Chul,Kim, Young‐,Myeong,Lee, Je‐,Wook,Kim, Su Jin,Kim, Eu John Wiley and Sons Inc. 2018 MOLECULAR ONCOLOGY Vol.12 No.3
<P>The C‐type lectin‐like domain of CLEC14a (CLEC14a‐C‐type lectin‐like domain [CTLD]) is a key domain that mediates endothelial cell–cell contacts in angiogenesis. However, the role of CLEC14a‐CTLD in pathological angiogenesis has not yet been clearly elucidated. In this study, through complementarity‐determining region grafting, consecutive deglycosylation, and functional isolation, we generated a novel anti‐angiogenic human monoclonal antibody that specifically targets CLEC14a‐CTLD and that shows improved stability and homogeneity relative to the parental antibody. We found that this antibody directly inhibits CLEC14a‐CTLD‐mediated endothelial cell–cell contact and simultaneously downregulates expression of CLEC14a on the surface of endothelial cells. Using various <I>in vitro</I> and <I>in vivo</I> functional assays, we demonstrated that this antibody effectively suppresses vascular endothelial growth factor (VEGF)‐dependent angiogenesis and tumor angiogenesis of SNU182 human hepatocellular carcinoma, CFPAC‐1 human pancreatic cancer, and U87 human glioma cells. Furthermore, we also found that this antibody significantly inhibits tumor angiogenesis of HCT116 and bevacizumab‐adapted HCT116 human colorectal cancer cells. These findings suggest that antibody targeting of CLEC14a‐CTLD has the potential to suppress VEGF‐dependent angiogenesis and tumor angiogenesis and that CLEC14a‐CTLD may be a novel anti‐angiogenic target for VEGF‐dependent angiogenesis and tumor angiogenesis.</P>
Kim, Hyun-Yi,Yang, Dong-Hwa,Shin, Song-Weon,Kim, Mi-Yeon,Yoon, Jae-Hyun,Kim, Suhyun,Park, Hae-Chul,Kang, Dong Woo,Min, DoSik,Hur, Man-Wook,Choi, Kang-Yell The Federation of American Societies for Experimen 2014 The FASEB Journal Vol.28 No.2
<P>CXXC5 is a member of a small subset of proteins containing CXXC-type zinc-finger domain. Here, we show that CXXC5 is a transcription factor activating <I>Flk-1</I>, a receptor for vascular endothelial growth factor. CXXC5 and Flk-1 were accmulated in nucli and membrane of mouse embryonic stem cells (mESCs), respectively, during their endothelial differentiation. CXXC5 overexpression induced <I>Flk-1</I> transcription in both endothelium-differentiated mESCs and human umbilical vein endothelial cells (HUVECs). <I>In vitro</I> DNA binding assay showed direct interaction of CXXC5 on the <I>Flk-1</I> promoter region, and mutation on its DNA-binding motif abolished transcriptional activity. We showed that bone morphorgeneic protein 4 (BMP4) induced <I>CXXC5</I> transcription in the cells, and inhibitors of BMP signaling suppressed the <I>CXXC5</I> induction and the consequent <I>Flk-1</I> induction by BMP4 treatment. <I>CXXC5</I> knockdown resulted in suppression of BMP4-induced stress fiber formation (56.8±1.3% decrease, <I>P</I><0.05) and migration (54.6±1.9% decrease, <I>P</I><0.05) in HUVECs. The <I>in vivo</I> roles of CXXC5 in BMP-signaling-specific vascular development and angiogenesis were shown by specific defect of caudal vein plex vessel formation (57.9±11.8% decrease, <I>P</I><0.05) in <I>cxxc5</I> morpholino-injected zebrafish embryos and by supression of BMP4-induced angigogensis in subcutaneously injected Matrigel plugs in <I>CXXC5</I><SUP>−/−</SUP> mice. Overall, CXXC5 is a transcriptional activator for <I>Flk-1</I>, mediating BMP signaling for differentiation and migration of endothelial cell and vessel formation.—Kim, H.-Y., Yang, D.-H., Shin, S.-W., Kim, M.-Y., Yoon, J.-H., Kim, S., Park, H.-C., Kang, D. W., Min, D., Hur, M.-W., Choi, K.-Y. CXXC5 is a transcriptional activator of <I>Flk-1</I> and mediates bone morphogenic protein-induced endothelial cell differentiation and vessel formation.</P>
Kim, Jin-Hee,Choi, In Ah,Lee, Joo Youn,Kim, Kyoung-Hwa,Kim, Sungtae,Koo, Ki-Tae,Kim, Tae-Il,Seol, Yang-Jo,Ku, Young,Rhyu, In-Chul,Song, Yeong Wook,Lee, Yong-Moo Korean Academy of Periodontology 2018 Journal of Periodontal & Implant Science Vol.48 No.6
Purpose: Periodontitis and rheumatoid arthritis (RA) share a similar inflammatory pathogenesis. Porphyromonas gingivalis (Pg) can induce anticyclic-citrullinated peptide autoantibodies (anti-CCP antibodies), a key factor in the development of RA. This study aimed at evaluating the relationships between the 2 diseases and identifying the clinical implications thereof, with a focus on periodontal pathogens in Korean adults. Methods: A total of 260 RA patients and 86 age- and sex-matched control patients without arthritis were enrolled in this prospective cross-sectional study. Periodontal indices and the prevalence and amount of periodontal pathogens were compared between the groups. Correlations between periodontal and RA indices were examined, as were correlations between 9 periodontal pathogens and RA indices. Results: The RA group had significantly higher values than the control group for all investigated periodontal indices (P<0.05) except the number of teeth. The gingival index (GI) was correlated with the disease activity score 28 (DAS28) (r=0.125, P=0.049), RA disease duration (r=0.253, P<0.001), erythrocyte sedimentation rate (ESR) (r=0.162, P=0.010), and anti-CCP antibody titer (r=0.205, P=0.004). Probing pocket depth (PPD) was correlated with ESR (r=0.139, P=0.027) and anti-Pg antibody titer (r=0.203, P=0.001). Bleeding on probing (BOP) was correlated with DAS28 (r=0.137, P=0.030), RA disease duration (r=0.202, P=0.001), ESR (r=0.136, P=0.030), anti-Pg antibody titer (r=0.177, P=0.005), and anti-CCP antibody titer (r=0.188, P=0.007). Clinical attachment level (CAL) and periodontitis severity were correlated with anti-Pg antibody titer (the former r=0.201, P=0.002; the latter r=0.175, P=0.006). The quantity of Pg was positively correlated with the serum anti-Pg antibody titer (r=0.148, P=0.020). Conclusions: The GI, BOP, and PPD showed positive relationships with several RA indices. The anti-Pg antibody titer had positive relationships with PPD, BOP, CAL, and periodontitis severity. Thus, increasing values of periodontal indices could be used as a risk indicator of disease development in RA patients, and an increasing anti-Pg antibody titer could be considered as a warning sign in RA patients suffering with periodontitis.
A novel LTPO AMOLED pixel circuit and driving scheme for variable refresh rate
Kim Jung Chul,Lee I. Sak,Kim Hyung Tae,An Jong Bin,Kim Jae Sung,Yoo Juhn Suk,Hwang Han Wook,Choi Hyun Chul,Ha Yong Min,Kim Hyun Jae 한국정보디스플레이학회 2023 Journal of information display Vol.24 No.4
This paper proposes a novel pixel circuit and driving scheme that adopts low-temperature polycrystalline silicon and oxide thin-film transistors (LTPO TFTs) for mobile devices using active-matrix organic light-emitting diode (AMOLED) displays. The proposed pixel circuit and driving scheme provide uniform luminance and render flicker invisible at variable refresh rates (VRRs) from 1 to 120 Hz. Using the proposed pixel circuit with extended compensation time (tCOMP) improves the luminance uniformity at a high-frame rate. The proposed driving scheme applies a voltage to the driving TFTs (D-TFTs) higher than the programmed data voltage during the skip frame. This reduces the flicker caused by the hysteresis of D-TFTs during low-frame rate driving. A 6.0-inch quad high-definition (QHD) LTPO-based AMOLED display was fabricated using the new pixel circuit and driving scheme. Experimental results of the proposed pixel circuit show that the standard deviation of luminance was reduced from 0.056 to 0.008 by extending tCOMP from 2 to 8 μs. The flicker level was−51 dB, so there was no visual artifact during 1 Hz driving. A flicker-free LTPO-based AMOLED display with low power consumption is possible; driving can proceed in 1–120 Hz range.
ZnO nanostructures with controlled morphologies on a glass substrate
Kim, Yong-Jin,Jeon, Jong-Myeong,Choi, Jun Hee,Park, Sung Soo,Kim, Sun Il,Baik, Chan Wook,Kim, Miyoung,Kim, Jong Min,Yi, Gyu-Chul IOP Pub 2010 Nanotechnology Vol.21 No.26
<P>We report morphology-controlled selective growth of ZnO nanostructures on glass substrates by using catalyst-free metal-organic chemical vapor deposition. For the morphology-controlled selective growth, a microheating method using a series of microheaters was developed, which provided well-controlled local heating based on the microheater geometry and spatial arrangement. ZnO nanostructure morphology depended on the local growth temperature, so various nanostructure morphologies were obtained selectively at specific positions on glass substrates by using local microheating. The monolithic integration of nanostructures with different morphologies will have great potential for applications in multifunctional devices. </P>
Kim, Sung-Geun,Park, Cho-Hyun,Kim, Kyung-Mi,Kim, Jae-Gue,Kim, Hyung-Ho,Park, Wong-Sang,Park, Jong-Jae,Lee, Mun-Su,Jung, Hyun-Chul,Jung, Hun-Yong,Han, Sang-Wook,Hyung, Woo-Jin,The Academic Committee of 대한위암학회 2010 Journal of gastric cancer Vol.10 No.3
We have always attempted to create a standard treatment protocol for patients with gastric cancer. However, many debates still exist regarding gastric cancer treatment. For the past 2 years, at the Annual Congress of the Korean Gastric Cancer Association, we have presented a grand symposium on the "Debates on the strategy for treating gastric cancer". In 2008, four major topics were discussed and voted on after discussion. The four major topics were proximal location treatment for early gastric cancer, management choices for pyloric obstruction with advanced gastric cancer, management of liver metastasis, and reconstruction methods after a distal gastrectomy. The opinions of the audience for six minor topics were expressed by an electronic voting system. In 2009, the four main topics were treatment for submucosal tumor sized around 2 cm, laparoscopic gastrectomy in T2N1 gastric cancer, choices for managing gastric lymphoma, and application of a pylorus preserving procedure for early gastric cancer at the antrum. The opinions of the audience for these six minor topics were expressed by an electronic voting system, as was conducted in 2008. It was good opportunity to identify a point of contact about the debates on managing gastric cancer. The results of these debates and studies will identify the best methods to treat patients with gastric cancer.