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- 저자 : Choudhury Shuvasish (검색결과 2 건)
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Unrevealing metabolomics for abiotic stress adaptation and tolerance in plants
Shuvasish Choudhury,Parul Sharma,Debojyoti Moulick,Mazumder Muhammed Khairujjaman 한국작물학회 2021 Journal of crop science and biotechnology Vol.24 No.5
The post-genomic era has witnessed several new possibilities to understand diverse functional aspects of plants quite precisely. From genomics to metabolomics and now phenomics, the complex interplay of these biological networks has been successfully elucidated. Abiotic stresses, such as drought, fooding, exposure to heavy metals and metalloids, and high or low temperature are foremost constraints in agriculture, and remains as the major reason for poor crop productivity and low yield globally. The primary aim of metabolomics is to identify fnal gene products, the metabolites, which serve as prospective markers (or traits) to comprehend abiotic stress adaptation and tolerance in plants. This review provides an overview on the application of metabolomics as a comprehensive tool for “Systems Biology Approach” to unravel the complex interaction of networks and components in plants towards abiotic stress adaptation and tolerance.
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Saikia Rubul,Choudhury Shuvasish,Borah Anupom,Mazumder Muhammed Khairujjaman 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.2
With ageing of the global population, and increased prevalence of diabetes and hypertension, the incidences of chronic kidney disease (CKD) is also on the rise. We have recently demonstrated that high adenine diet leads to CKD with hyperuricemia, and deposition of uroliths of adenine and 2, 8-dihydroxyadenine. Production of uric acid and 2,8-dihydroxyadenine are catalyzed by xanthine oxidoreductase (XOR). The present study was undertaken to elucidate renoprotective potentials of aqueous fruit extract of Garcinia pedunculata (2% w/v mixed with drinking water) in animal model of CKD, in terms of serum parameters and urolithiasis. To develop the mice model, the mice were given high adenine (0.3% w/w) diet mixed with feed. Elevation in the levels of serum urea and uric acid, and renal histopathological changes were regarded as parameters to validate the model. Aqueous fruit extract of G. pedunculata significantly ameliorated the serum levels of urea and uric acid, and histological alterations. Since Garcinol is one of the principal constituents of the plant, computational modelling was performed to determine inhibitory potential of Garcinol on XOR. The computational modelling revealed that Garcinol may directly inhibit XOR by interacting with the active site of the enzyme. Our findings demonstrated that the fruit extract of G. pedunculata may ameliorate adenine-induced CKD in mice, in terms of haematological and histopathological changes, the mechanism of which has been proposed to be inhibition of XOR by Garcinol. Thus, the present study is important in the treatment paradigm of CKD as a whole, and urolithiasis and hyperuricemia in particular.
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