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        Longitudinal Changes in Physical and Cognitive Functions among Participants with and without Rheumatoid Arthritis in Community-Dwelling Middle-Aged and Older Adults

        Mikako Yasuoka,Chikako Tange,Yukiko Nishita,Makiko Tomida,Ryota Watanabe,Hiroshi Shimokata,Rei Otsuka,Masayo Kojima 대한노인병학회 2023 Annals of geriatric medicine and research Vol.27 No.1

        Background: This study evaluated the chronological changes in physical and cognitive functions in middle-aged and older adults with and without rheumatoid arthritis (RA). Methods: This population-based case-control longitudinal study included individuals aged 40–79 years at baseline who agreed to participate. We identified 42 participants with RA and randomly selected 84 ageand sex-matched controls. Physical function was assessed according to gait speed, grip strength, and skeletal muscle mass. Cognitive function was assessed based on the information, similarities, picture completion, and digit symbol substitution test scores of the Wechsler Adult Intelligence Scale-Revised Short Form. The general linear mixed models comprised the fixed effects of the intercept, case, age, time in years since baseline, and case×time interaction, which were used to examine longitudinal changes in physical and cognitive functions. Results: Regardless of RA status, grip strength decreased and the picture completion score increased in the group aged <65 years, while skeletal muscle mass index and gait speed decreased in the group aged ≥65 years. The interaction of case×follow-up years for grip strength in the group aged ≥65 years was significant (p=0.03). The decline in grip strength in the control group (slope=-0.45) was greater than that in the RA group (slope=-0.19). Conclusion: Chronological changes in physical and cognitive functions were comparable between participants with and without RA; however, the decline in grip strength in the control group was greater among older adults with RA.

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        고령자의 기능적 체력과 인지기능 저하와의 관련-10년간의 장기종단연구

        이성철(Sungchul Lee),니시타 유키코(Yukiko Nishita),탄게 치카고(Chikako Tange),오츠카 레이(Rei Otsuka),안도 후지코(Fujiko Ando),시모카타 히로시(Hisoshi Shimokata),장명재(Myong-Jae Chang),최현민(Hyun-Min Choi) 한국생활환경학회 2016 한국생활환경학회지 Vol.23 No.5

        The purpose of this study was to examine whether functional fitness predicts subsequent cognitive decline in community dwelling older adults. The subjects were 1094 (556 men and 538 women) adults aged 60 years or older who completed the baseline (2000-2002) and ten years later (2010-2012) examinations of the National Institute for Longevity Science-Longitudinal Study of Aging (NILS-LSA) in Japan. We examined associations at baseline and over a 10-year follow-up period between seven functional fitness measures: gait speed, step length, one leg standing, reaction time, leg extension power, grip strength and knee extension strength and mini-mental state examination (MMSE). Multivariate logistic regression was used to examine the relationships between functional fitness and cognitive function decline every two years. There was a significant association between the reaction time and risk of becoming decrease to 23 points of MMSE in both model Ⅰ and model Ⅱ of all waves in men and women for 10 years. Gait speed was related to decrease in the cognitive function from after six years (5th wave) in both men (OR, 0.72; CI, 0.53-0.95) and women (OR, 0.79; CI, 0.54-0.97). Leg extension power and grip strength of the physical function were associated with cognitive function decline from after six years it was found in men only. In the women case, it was showed after 10 years. Functional fitness was identified as factors that can predict the decrease in cognitive function. But it turned out that the functional fitness related to cognitive function decreases depending on the time and gender are different.

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        지역 거주 고령자를 대상으로 신체기능과 인지기능과의 관련성 연구

        이성철(Sung-Chul Lee),니시타 유키코(Yukiko Nishita),탄게 치카고(Chikako Tange),오츠카 레이(Rei Otsuka),안도 후지코(Ando Fujiko),시모카타 히로시(Hisoshi Shimokata),장명재(Myoung-Jei Chang),최현민(Hyun-Min Choi) 한국생활환경학회 2015 한국생활환경학회지 Vol.22 No.5

        Cognitive decline and dementia are associated with disability and premature death in old age. We examined whether physical function predicts subsequent cognitive decline in older Japanese. There were 557 adult subjects (293 men and 264 women) aged 60 years or older who completed the baseline evaluation (2000-2002) and final evaluation 8 years later (2008-2010) of the NILS-LSA in Japan. We examined associations at the baseline and after an 8-year follow-up period between MMSE and six physical performance measures: gait speed, one leg standing with eyes closed, reaction time, leg extension power, grip strength and knee extension strength. We examined the effect of physical function on cognitive decline (at least a 3-point decline on the MMSE) by multiple logistic regression controlled for age, sex, BMI, MMSE score at baseline, smoking, self-rated health, CES-D, education, medical history and moderate to vigorous physical activity time. There was a significant association between the leg extension power (OR, 0.26; CI, 0.10-0.68) and the risk of a decrease of up to 3 points in Model 1 was adjusted for age and education. In Model II, leg extension power (OR, 0.28; CI, 0.10-0.76) was related to a decrease in the cognitive function over time and remained statistically significant after controlling for all covariates. However, the other physical functions were not statistically significant in either the limited or full adjustment models. Older Japanese with reduced leg extension power at baseline demonstrated a statistically significant decline in cognitive function over an 8-year period.

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