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Chinese Patterns of University-Industry Collaboration
Chen, Xiangdong,Yang, Jian-An,Park, Hyun-Woo Asian Society for Innovation and Policy 2012 Asian Journal of Innovation and Policy Vol.1 No.1
This paper deals with university - industry collaboration movement in China in recent years. By summarizing related development background in Government-Industry-University framework, the paper specifies Chinese pattern through analysis of technology transfer between universities and industries, collaborative R&D between universities and industries in practical fields, and university-run high-tech companies, especially through analysis of joint patenting between universities and their industrial partners in China. The research provides clear picture of Chinese universities' increased development with industrial entities in comprehensive and wider technology fields.
Chinese Patterns of University-Industry Collaboration
Xiangdong Chen 아시아기술혁신학회 2012 Asian Journal of Innovation and Policy Vol.1 No.1
This paper deals with university – industry collaboration movement in China in recent years. By summarizing related development background in Government-Industry-University framework, the paper specifies Chinese pattern through analysis of technology transfer between universities and industries, collaborative R&D between universities and industries in practical fields, and university-run high-tech companies, especially through analysis of joint patenting between universities and their industrial partners in China. The research provides clear picture of Chinese universities’ increased development with industrial entities in comprehensive and wider technology fields.
Modification of surface/neuron interfaces for neural cell-type specific responses: a review
Chen, Cen,Kong, Xiangdong,Lee, In-Seop Institute of Physics Publishing Ltd 2016 Biomedical Materials Vol.11 No.1
<P>Surface/neuron interfaces have played an important role in neural repair including neural prostheses and tissue engineered scaffolds. This comprehensive literature review covers recent studies on the modification of surface/neuron interfaces. These interfaces are identified in cases both where the surfaces of substrates or scaffolds were in direct contact with cells and where the surfaces were modified to facilitate cell adhesion and controlling cell-type specific responses. Different sources of cells for neural repair are described, such as pheochromocytoma neuronal-like cell, neural stem cell (NSC), embryonic stem cell (ESC), mesenchymal stem cell (MSC) and induced pluripotent stem cell (iPS). Commonly modified methods are discussed including patterned surfaces at micro- or nanoscale, surface modification with conducting coatings, and functionalized surfaces with immobilized bioactive molecules. These approaches to control cell-type specific responses have enormous potential implications in neural repair.</P>
Biomimetic apatite formed on cobalt-chromium alloy: A polymer-free carrier for drug eluting stent
Chen, Cen,Yao, Chenxue,Yang, Jingxin,Luo, Dandan,Kong, Xiangdong,Chung, Sung-Min,Lee, In-Seop Elsevier 2017 Colloids and surfaces Biointerfaces Vol.151 No.-
<P><B>Abstract</B></P> <P>In this study, sirolimus (SRL) was loaded within biomimetic apatite formed on cobalt-chromium (Co-Cr) alloy, which has been reported for the first time, to inhibit the in-stent restenosis. Two different groups of loading SRL within biomimetic apatite were prepared: Group A (mono-layer of apatite/SRL) and Group B (bi-layer of apatite/SRL). Group A and Group B showed the biphasic pattern of SRL release up to 40 and 90days, respectively. The attachment of human artery smooth muscle cell (HASMC) for both Group A and Group B was significantly inhibited, and proliferation dramatically decreased with the release of SRL. Noteworthily, biomimetic apatite alone also suppressed the SMC proliferation. The porous biomimetic apatite uniformly covered Co-Cr stent without crack or webbings. After balloon expansion, the integrity of biomimetic apatite was sufficient to resist delamination or destruction. Thus, this study demonstrated that biomimetic apatite is a promising drug carrier for potential use in stents.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Biomimetic apatite is formed on Co-Cr alloy as a polymer-free drug carrier. </LI> <LI> To inhibit in-stent restenosis, sirolimus is loaded within apatite in two ways. </LI> <LI> Porous and biodegradable biomimetic apatite releases of sirolimus over 40days. </LI> <LI> Integrity of biomimetic apatite is sufficient for clamping and balloon expansion. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Chen, Cen,Li, Han,Kong, Xiangdong,Zhang, Sheng-Min,Lee, In-Seop Dove Medical Press 2015 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.10 No.-
<P>In this study, to improve the osseointegration of implants, osteogenic growth peptide (OGP) and fibronectin (FN) were loaded within mineral, which was formed on titanium, through adsorption and coprecipitation methods. The release profiles of OGP loaded by either adsorption or coprecipitation and the effects of the loading methods to immobilize OGP with and without FN on rat mesenchymal stem cell (rMSC) osteogenic differentiation were studied. The coprecipitation approach slightly reduced the initial burst release, while the adsorption approach provided a more sustained release. Dual loading of OGP and FN further improved cell attachments compared with either OGP or FN alone. Dually loaded OGP and FN also had a positive impact on rMSC proliferation and osteogenic differentiation. The difference in methods of loading OGP with and without FN also had some effects on osteogenic differentiation. Compared with coprecipitated OGP alone, adsorbed OGP enhanced later differentiation, such as osteocalcin secretion and matrix mineralization. Simultaneously adsorbed OGP and FN led to higher proliferation and higher osteogenic differentiation in both early and late stages compared with sequentially loaded OGP and FN. rMSC culture clearly indicated that simultaneously adsorbed OGP and FN could improve osseointegration, and this treatment represents a potential method for effective surface modification of dental and orthopedic implants.</P>
Xiangdong Zhou,Yufa Sun,Yingchun Chen,Bing Sun 한국고분자학회 2018 폴리머 Vol.42 No.2
Monomer of polyamide (PA66) and flame-retardant intermediate product (FR) were firstly synthesized, and the flame-retardant (PA-FR) was further gained by polymerization of PA66 and FR. The structure of PA-FR was confirmed by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy (NMR), X-ray photoelectron spectroscopy (XPS), and gel permeation chromatography (GPC). The thermal properties of PA-FR and the finished fabric were evaluated by thermal gravity analysis (TGA) and differential scanning calorimetry (DSC). Moreover, X-ray diffraction analysis (XRD) showed that melting eutectic reaction occurred between PA-FR and nylon fabric. The experimental results showed that the limiting oxygen index (LOI) value of PA-FR treated fabric and PA-FR treated fabric after 10 laundries were improved to 28.8% and 26.4%, respectively. It implied that PA-FR had a good and durable function of imparting fire-resistance to nylon fabric.
Synthesis of a Block Silicone Softener by Alkali Method and Its Application on Cotton Fabric
Kun Chen,Xiangdong Zhou 한국고분자학회 2020 폴리머 Vol.44 No.2
A block silicone softener (ATSO-PDE) was synthesized by alkali method with amino-terminated polysiloxane (ATSO) and polypropylene glycol diglycidyl ether (PDE) as raw materials. The chemical structure of amino-terminated siloxane (ATS) was characterized by 1H NMR, 13C NMR, and FTIR. The main factors affecting ATSO conversion rate and properties of product were investigated. The optimal ring opening reaction condition of ATSO was 110℃ for 2 h. The application of ATSO-PDE on cotton fabrics indicated that fabrics treated by softener with high ammonia value (0.70 mmol/g) expressed good softness while softener with low ammonia value (0.40 mmol/g) expressed good smoothness. The adsorption mechanism and orientation distribution of silicone softener on the fibers were analyzed by the establishment of the orientation distribution model. It was indicated that the different properties and surface morphology of ATSO-PDE were related to the molecular structure and the orientation on the surface of the fiber.
Sun, Xiangdong,Wang, Zhixuan,Zhang, Qi,Chen, Guitao The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.2
For dual-active-bridge (DAB) DC-DC converters, a variable frequency triple-phase-shift (VF-TPS) modulation strategy based on a particle swarm optimization (PSO) algorithm was proposed to solve the problem of the low efficiency of TPS modulation in larger power conditions. To facilitate the implementation of the PSO algorithm, the mathematical expressions between the transmission power or the RMS square of the inductance current and four control variables including the switching frequency and three phase-shift duty cycles are simplified by the Fourier series decomposition method. An objective function of the particle fitness is presented to find the optimal control variables at any reference transmission power, which achieves the minimum inductance RMS current in the full power range and improves the efficiency under heavy loads. In addition, the PSO algorithm is used to design the appropriate switching frequency range and inductance. Finally, a 1.2 kW DAB converter prototype was established, and experimental results verify the correctness and feasibility of the modulation strategy.