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Song, Chaoran,Hong, Yo Han,Park, Jae Gwang,Kim, Han Gyung,Jeong, Deok,Oh, Junsang,Sung, Gi-Ho,Hossain, Mohammad Amjad,Taamalli, Amani,Kim, Ji Hye,Kim, Jong-Hoon,Cho, Jae Youl Elsevier 2019 Journal of Ethnopharmacology Vol.235 No.-
<P><B>Abstract</B></P> <P><B>Ethnopharmacological relevance</B></P> <P> <I>Olea europaea</I> L., (Oleaceae) has been used widely in folk medicine in the European Mediterranean islands, India, Asia, and other parts of the world. Although this plant has high ethnopharmacological value for treating inflammatory diseases, the molecular mechanisms of how it inhibits the inflammatory response are not fully understood. In this study, we sought to identify the anti-inflammatory mechanisms of this plant.</P> <P><B>Materials and methods</B></P> <P>Using macrophages, we investigated the effects of <I>O. europaea</I> L. methanol extract (Oe-ME) and ethanol extract (Oe-EE) on the production of inflammatory mediator nitric oxide (NO) and prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>), the expression levels of pro-inflammatory genes and intracellular inflammatory signaling activities.</P> <P><B>Results</B></P> <P>Oe-ME and Oe-EE suppressed the production of NO in lipopolysaccharide-(LPS-), Pam3CSK4-, and poly (I:C)-stimulated RAW264.7 cells; importantly, no cytotoxicity was observed. Oe-ME and Oe-EE reduced production of PGE<SUB>2</SUB> without exhibiting cytotoxicity. The mRNA expression levels of cyclooxygenase-2 (COX-2), inducible NO synthase (iNOS), IL-6, IL-1β, and tumor necrosis factor (TNF)-α were down-regulated by Oe-ME and Oe-EE. Nuclear fraction and whole lysate immunoblotting analyses and overexpression experiments strongly suggested that Oe-ME decreased the translocation of p65 and p50 (nuclear factors of the NF-κB subunit) as well as Src and Syk.</P> <P><B>Conclusion</B></P> <P>These results suggest that Oe-ME exerts its anti-inflammatory effects by targeting Src and Syk in the NF-κB signaling pathway.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Transparent Fluorinated Poly(imide siloxane) Copolymers with Good Adhesivity
Linshuang Li,Yong Xu,Jianfei Che,Xu Su,Chaoran Song,Xiuping Ma 한국고분자학회 2017 Macromolecular Research Vol.25 No.11
A series of fluorinated poly(imide siloxane) (PIS) copolymers were prepared with fluorine dianhydride 4,4'-(hexafluoroisopropylidene)diphthalic anhydride (6FDA) and two kinds of functional diamine, 2,2'-bis(trifluoromethyl)-[ 1,1'-biphenyl]-4,4'-diamine (TFMB) and 1,3-bis(3-aminopropyl) tetramethyldisiloxane (GAPD) via a conventional two-stage process with thermal imidization. The soft and hard segments in the copolymer chain were composed of 6FDA-GAPD and 6FDA-TFMB, respectively. The structure of the resulting copolymers was determined by Fourier transform infrared (FT-IR) and 1H nuclear magnetic resonance (1H NMR) spectroscopy. Optical, adhesion, mechanical, and thermal properties of these PIS copolymers have been evaluated with respect to real siloxane loading kept to 0, 1.4, 2.6, 4.1, and 5.5wt% in the copolymers, which is lower than the theoretical content of siloxane loading due to a disproportionation reaction of the siloxane chain. The resulting PIS copolymers showed excellent optical transparency in the UV-visible range and good adhesion property. The cutoff absorption wavelength (λ0) of the resulting PIS copolymers films was less than 345 nm and the maximum transmittance (λmax) was up to 91%. The introduction of siloxane segment dramatically improved the adhesion property of PIS copolymers from 1.29 to 2.26MPa (measured by means of shear strength) compared to the fluorinated homopolyimide (6FDA-TFMB) synthesized without siloxane moiety. The thermal and mechanical properties of the resulting PIS copolymers decreased slightly with the increase in siloxane loading but still remain a good level. Due to the addition of trifluoromethyl (-CF3) group and siloxane moiety, the solubility of PIS films was greatly enhanced and they were able to be dissolved in polar aprotic solvents, such as DMAC, DMF, and NMP. The contact angle, surface energy and water absorption were also studied in order to discuss their hydrophobic property.
Photoaging Protective Effects of BIOGF1K, a Compound-K-Rich Fraction Prepared from Panax ginseng
Yo Han Hong(홍요한),Sang Hee Park(박상희),Nur Aziz(누르 아지즈),Rojas Lorz Laura(로하스 롤스 라우라),Nurinanda Prisky Qomaladewi(누리난다 프리스키 쿠말라데위),Chaoran Song(송차오란),Stephanie Triseptya Hunto(스테파니 트리셉티아 훈토),Jae Youl Cho( 한국약용작물학회 2017 한국약용작물학회 학술대회논문집 Vol.2017 No.2
Anti-melanogenesis nd Skin Protective Activity of Panax ginseng Calyx Ethanol Extract
Sang Yun Han(한상윤),Eun Ji Kim(김은지),Yohan Hong(홍요한),Han Gyung Kim(김한경),Deok Jeong(정덕),Sang Hee Park(박상희),Nurinanda Prisky Qomaladewi,Song Chaoran,Nur Aziz,Rojas Lorz Laura,Jae Youl Cho(조재열) 한국약용작물학회 2019 한국약용작물학회 학술대회논문집 Vol.2019 No.2