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H<sub>2</sub>O<sub>2</sub>로 유도된 C6 신경교세포의 세포사멸에 대한 감초 추출물과 감초 활성물질의 보호효과
박찬흠,김지현,최승학,신유수,이상원,조은주,Park, Chan Hum,Kim, Ji Hyun,Choi, Seung Hak,Shin, Yu Su,Lee, Sang Won,Cho, Eun Ju 한국약용작물학회 2017 한국약용작물학회지 Vol.25 No.5
Background: Glycyrrhiza uralensis Radix (GR) is a crude drugs used in Asian countries that has been reported to prevent the progression of neurodegenerative diseases such as Alzheimer's disease. The present study examined whether GR and its active compounds, glycyrrhizic acid (GA) and isoliquiritigenin (IL), exerted protective effects on $H_2O_2$-induced oxidative damage in C6 glial cells. Methods and Results: We exposed C6 glial cells to hydrogen peroxide ($H_2O_2$) for 24 h and investigated the cellular response to GR and its active compounds by evaluating cell viability, reactivie oxygen species (ROS) production, and apoptosis-related protein expression. GR successfully mitigated the reduced cell viability and ROS production induced by $H_2O_2$ in C6 glial cells, IL and GA significantly increased the cell viability and decreased ROS production. In addition, IL and GA down-regulated apoptotic Baxdependent caspase-3 activation, but each compound exerted different mechanisms, i.e., IL dose-dependently decreased ROS production and, GA up-regulated anti-apoptotic Bcl-2 expression. Conclusions: These results demonstrated that GR and its active components, IL and GA, exhibit potential for use as natural neurodegenerative agents for the modulation of apoptosis in C6 glial cells.
기억장애성 경도인지장애 환자에서 해마대사량의 감소: 양전자방출단층촬영연구
박찬흠(Chan hum Park),이영민(Young Min Lee),박제민(JeMin Park),이병대(Byung Dae Lee),문은수(EunSoo Moon),정희정(Hee Jeong Jeong),김수연(Soo Yeon Kim),이강윤(Kang Yoon Lee),서화규(Hwagyu Suh),박혜경(Hye Kyung Park),김학진(Hak-Jin Kim) 대한노인정신의학회 2020 노인정신의학 Vol.24 No.1
Objective: Little is known about factors influencing of hippocampal metabolism (HM) in mild cognitive impairment (MCI). Our objective was to determine whether HM in patients with amnestic MCI (aMCI) is decreased than non-amnestic MCI (naMCI). Methods: Overall, 32 MCI patients underwent 18F-fluorodeoxyglucose-positron emission tomography. They were characterized as aMCI (n=18) or naMCI (n=14) according to comprehensive neuropsychological criteria. Analysis of variances were used to assess differences on HM between aMCI and naMCI after controlling age, sex, education and Korean version of Mini Mental Status Examination. Results: We found that HM was more decreased in aMCI than naMCI. This result was not changed after controlling hippocampal volume. Conclusion: Our findings suggest that aMCI is associated with decreased HM in MCI.