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RISS 인기검색어
- 검색키워드
- 저자 : Caspi, Lilac H. (검색결과 3 건)
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Caspi, S.,Arbelaez, D.,Felice, H.,Hafalia, R.,Robin, D.,Sun, C.,Wan, W.,Yoon, M. IEEE 2012 IEEE transactions on applied superconductivity Vol.22 No.3
<P>A conceptual design of curved superconducting magnet for a carbon therapy gantry has been proposed. The design can reduce the gantry's size and weight and make it more comparable with gantries used for proton therapy. In this paper we report on a combined function, 5 T, superconducting dipole magnet with a 260 mm bore diameter that is curved 90 degrees at a radius of 1269 mm. The magnet superimposes two layers of oppositely wound and skewed solenoids like windings, energized in a way that nulls the solenoid field and doubles the dipole field component. Furthermore, the combined architecture of the windings can create a selection of field terms that are off the near-pure dipole field. Combined harmonics such as a quadrupole and sextupole are needed to adjust the beam trajectory. Ways to adjust the field and beam trajectory, magnet size and assembly, structure and pre-stress are considered.</P>
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Braten, Ori,Livneh, Ido,Ziv, Tamar,Admon, Arie,Kehat, Izhak,Caspi, Lilac H.,Gonen, Hedva,Bercovich, Beatrice,Godzik, Adam,Jahandideh, Samad,Jaroszewski, Lukasz,Sommer, Thomas,Kwon, Yong Tae,Guharoy, M National Academy of Sciences 2016 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.113 No.32
<P>The 'canonical' proteasomal degradation signal is a substrate-anchored polyubiquitin chain. However, a handful of proteins were shown to be targeted following monoubiquitination. In this study, we established-in both human and yeast cells-a systematic approach for the identification of monoubiquitination-dependent proteasomal substrates. The cellular wild-type polymerizable ubiquitin was replaced with ubiquitin that cannot form chains. Using proteomic analysis, we screened for substrates that are nevertheless degraded under these conditions compared with those that are stabilized, and therefore require polyubiquitination for their degradation. For randomly sampled representative substrates, we confirmed that their cellular stability is in agreement with our screening prediction. Importantly, the two groups display unique features: monoubiquitinated substrates are smaller than the polyubiquitinated ones, are enriched in specific pathways, and, in humans, are structurally less disordered. We suggest that monoubiquitination-dependent degradation is more widespread than assumed previously, and plays key roles in various cellular processes.</P>
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Lapauw, Thomas,Tytko, Darius,Vanmeensel, Kim,Huang, Shuigen,Choi, Pyuck-Pa,Raabe, Dierk,Caspi, El’ad N.,Ozeri, Offir,to Baben, Moritz,Schneider, Jochen M.,Lambrinou, Konstantina,Vleugels, Jozef American Chemical Society 2016 Inorganic Chemistry Vol.55 No.11
<P>The solubility of zirconium (Zr) in the Nb<SUB>4</SUB>AlC<SUB>3</SUB> host lattice was investigated by combining the experimental synthesis of (Nb<SUB><I>x</I></SUB>, Zr<SUB>1–<I>x</I></SUB>)<SUB>4</SUB>AlC<SUB>3</SUB> solid solutions with density functional theory calculations. High-purity solid solutions were prepared by reactive hot pressing of NbH<SUB>0.89</SUB>, ZrH<SUB>2</SUB>, Al, and C starting powder mixtures. The crystal structure of the produced solid solutions was determined using X-ray and neutron diffraction. The limited Zr solubility (maximum of 18.5% of the Nb content in the host lattice) in Nb<SUB>4</SUB>AlC<SUB>3</SUB> observed experimentally is consistent with the calculated minimum in the energy of mixing. The lattice parameters and microstructure were evaluated over the entire solubility range, while the chemical composition of (Nb<SUB>0.85</SUB>, Zr<SUB>0.15</SUB>)<SUB>4</SUB>AlC<SUB>3</SUB> was mapped using atom probe tomography. The hardness, Young’s modulus, and fracture toughness at room temperature as well as the high-temperature flexural strength and E-modulus of (Nb<SUB>0.85</SUB>, Zr<SUB>0.15</SUB>)<SUB>4</SUB>AlC<SUB>3</SUB> were investigated and compared to those of pure Nb<SUB>4</SUB>AlC<SUB>3</SUB>. Quite remarkably, an appreciable increase in fracture toughness was observed from 6.6 ± 0.1 MPa/m<SUP>1/2</SUP> for pure Nb<SUB>4</SUB>AlC<SUB>3</SUB> to 10.1 ± 0.3 MPa/m<SUP>1/2</SUP> for the (Nb<SUB>0.85</SUB>, Zr<SUB>0.15</SUB>)<SUB>4</SUB>AlC<SUB>3</SUB> solid solution.</P><P>The solubility of Zr in nanolaminated (Nb<SUB>1−<I>x</I></SUB>, Zr<SUB><I>x</I></SUB>)<SUB>4</SUB>AlC<SUB>3</SUB> is investigated. Experimentally, a maximum at <I>x</I> = 18.5% is found, which is consistent with a minimum in the calculated energy of mixing at low Zr contents. The mechanical behavior of this solid solution shows a significant improvement in fracture toughness and temperature stability compared to those of Nb<SUB>4</SUB>AlC<SUB>3</SUB>.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/inocaj/2016/inocaj.2016.55.issue-11/acs.inorgchem.6b00484/production/images/medium/ic-2016-00484u_0007.gif'></P>
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