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- 저자 : Casassus, S. (검색결과 2 건)
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( Philippe Rodon ),( Brigitte Pegourie ),( Laurent Garderet ),( Philippe Casassus ),( Olivier Decaux ),( Murielle Roussel ),( Carine Chaleteix ),( Bruno Royer ),( Mourad Tiab ),( Xavier Leleu ),( Clai 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Although infection is a major complication of multiple myeloma (MM), there are few data on its incidence, presentation and outcome. We reviewed severe infections occurring in the IFM 2009 01 protocol. Methods: The IFM 2009 01 protocol evaluated a combination of bendamustine, bortezomib and dexamethasone (BVD) in the treatment of elderly patients (65 years or more) with a relapsed or refractory (RR) MM (Rodon P. et al, Blood 2013;122:1971A). Patients did not receive any prophylactic antibiotics. All adverse events were collected and graded prospectively. We report here an analysis of the episodes of severe infection (grade 3 or more). Results: Seventy-three patients were included. The median age was 75.8 years (range 66-86). Twenty episodes of grade 3 or more infection occurred in 17 patients (23.2%): lung and respiratory tract infection 13 episodes, bloodstream infection 6 episodes and pyelonephritis 1 episode, respectively. Fourteen episodes were diagnosed in the early phase of therapy (within the 4 fi rst BVD cycles). Only 1 severe infection underwent during a chemotherapy-induced neutropenic phase (absolute neutrophil count < 1000/mm3). fifteen episodes occurred among 34 patients older than 75 years versus 5 episodes in 39 younger patients (p=0.0028). Sepsis was responsible of death in 4 of these 17 patients (23.5%), all occurring in the early phase. Conclusions: Infection was a major severe adverse event in elderly patients treated for RRMM in the IFM 2009 01 protocol, occurring in approximately one quarter of the patients. Its incidence was signifi cantly higher in patients older than 75 years. Severe episodes of infection mainly occurred in the early phase of treatment. Mortality rate was high. These fi ndings suggest that a systematic prophylactic use of antibiotics may be needed in this population of patients.
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The State-of-Play of Anomalous Microwave Emission (AME) research
Dickinson, Clive,Ali-Haï,moud, Y.,Barr, A.,Battistelli, E.S.,Bell, A.,Bernstein, L.,Casassus, S.,Cleary, K.,Draine, B.T.,Gé,nova-Santos, R.,Harper, S.E.,Hensley, B.,Hill-Valler, J.,Hoang, Th Elsevier 2018 New astronomy reviews Vol.80 No.-
<P><B>Abstract</B></P> <P>Anomalous Microwave Emission (AME) is a component of diffuse Galactic radiation observed at frequencies in the range ≈ 10–60 GHz. AME was first detected in 1996 and recognised as an additional component of emission in 1997. Since then, AME has been observed by a range of experiments and in a variety of environments. AME is spatially correlated with far-IR thermal dust emission but cannot be explained by synchrotron or free–free emission mechanisms, and is far in excess of the emission contributed by thermal dust emission with the power-law opacity consistent with the observed emission at sub-mm wavelengths. Polarization observations have shown that AME is very weakly polarized ( ≲ 1 %). The most natural explanation for AME is rotational emission from ultra-small dust grains (“spinning dust”), first postulated in 1957. Magnetic dipole radiation from thermal fluctuations in the magnetization of magnetic grain materials may also be contributing to the AME, particularly at higher frequencies ( ≳ 50 GHz). AME is also an important foreground for Cosmic Microwave Background analyses. This paper presents a review and the current state-of-play in AME research, which was discussed in an AME workshop held at ESTEC, The Netherlands, June 2016.</P>
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