Gynecologic oncology group trials in uterine corpus malignancies: recent progress

David Scott Miller1,Louise P. King 대한부인종양학회 2008 Journal of Gynecologic Oncology Vol.19 No.4

The Gynecologic Oncology Group (GOG) has conducted multiple trials related to malignancies of the uterine corpus. Recently, several of these trials have been presented and/or published. Areas of focus included the feasibility of laparoscopic staging for endometrial cancer, the adjuvant management of locally advanced endometrial cancer, whole abdominal irradiation in maximally resected advanced endometrial carcinoma, and combination chemotherapy regimens for stage I and II carcinosarcoma after primary surgery and for advanced or recurrent carcinosarcoma. This article will discuss the background and details of each of these important advances. The Gynecologic Oncology Group (GOG) has conducted multiple trials related to malignancies of the uterine corpus. Recently, several of these trials have been presented and/or published. Areas of focus included the feasibility of laparoscopic staging for endometrial cancer, the adjuvant management of locally advanced endometrial cancer, whole abdominal irradiation in maximally resected advanced endometrial carcinoma, and combination chemotherapy regimens for stage I and II carcinosarcoma after primary surgery and for advanced or recurrent carcinosarcoma. This article will discuss the background and details of each of these important advances.

The Living Human Web: A Twenty-Five Year Retrospective

( Bonnie J. Miller-mclemore ) 한국목회상담학회 2018 목회와 상담 Vol.30 No.-

“The living human web” as the subject matter in pastoral theology arose twenty-five years ago in the context of the western individualistic society in which its previous counterpart “the living human document” had appeared about seven decades before. The metaphor captures ideas on the wider cultural and political contexts where pastoral care is located, especially in the hope of responding to the challenge of political and social injustice. Psychology in the United States appealed in the earlier years of pastoral care because of its deep respect for personal experience while it contributed to the disillusionment of academic theology in pastoral theology. The previous metaphor of the living human document depended heavily on the vivid clinical cases; in turn, the living human web that Miller-McLemore coined in the early 1990s was intended to capture “context, collaboration, and diversity” beyond individual counseling sessions. Underneath the shift of the paradigms, three trends can be identified as contributing factors: interest in congregational studies; a call for a new public theology; and the rise of liberation movements. With the advent of the new metaphor in pastoral care, the definition of genuine care has been changed as requiring an understanding of social sciences such as economics and political sciences as tools of interpretation. The meaning of the living human web has continued to develop until the day and there are four different emphases worth noting: political/liberationist, ecological/contextual, congregational, and educational/ministerial. Regardless of changing of metaphors, however, empathy that matters always in pastoral care is to be sustained by giving voice to the silenced and oppressed by others in culture.

Luther on the Turks and Islam

Gregory J. Miller 루터대학교 루터연구소 2003 루터 硏究 Vol.17 No.-

S-1. Baculovirus 에 삽입한 Copia 와 같은 운반요소의 성질

( L . K . Miller ) 한국균학회 1983 韓國菌學會誌 Vol.11 No.1

The Nature of a Copia - Like Transposable Element Inserted in a Baculovirus

Miller, Lois K 한국유전학회 1982 Genes & Genomics Vol.4 No.2

Baculoviruses possess large (∼ 100 Kilobase pair), double-stranded, circular DNA genome which are packaged in enveloped, rod-shaped capsids. A mutant of the baculovirus Autographa californica nuclear polyheadrosis virus (AcNPV) was recently isolated following serial passage of the virus through a cell line of the lepidopteran insect Trichoplusia ni. The mutant, known as FP-D, has a most unusual genotype; restriction endonuclease analysis of the viral DNA reveals the presence of a genetically unstable sequence inserted in the mutant DNA. Further analysis has established that this sequence is a mobile genetic element of T. ni and is a member of the copia-like class of transposable elements. We call the element TE-D. TE-D is 7.3 Kilobases (Kb) in length and contains 0.27 Kb direct terminal repeats so that its structure is similar to copia-like elements of Drosophila as well as the evolutionarily related retroviruses of vertebrates. The TE-D sequence is genetically unstable; a second virus, referred to as FP-DS, arises spontaneously and at high frequency in FP-D infected cells. FP-DS contains only one of the two 0.27 Kb terminal repeats of TE-D and may arise from recombination between the direct terminal repeats of TE-D. We also have evidence that the element exists in free linear and circular form in FP-D infected cells; transposition of the element may therefore involve a 7.05 Kb circular and/or linear intermediate. TE-D is a mid-repetitive, dispersed element of T. ni cells. It is found in 45 or 50 different locations in the T. ni genome. The element is mobile as determined by experiment in which the position of TE-D sequences have amplified several fold and the internal sequences of TE-D have diverged slightly. We are currently investigating the effects of element insertion on viral transcription and have observed the enhancement of transcription of viral sequences next to terminal repeats. FP-D will be a very valuable tool for studying transposable element movement and expression. We have a permissive insect cell line, S. frugiperda, which lacks TE-D so that the element can be studied in a naive cell environment. We expect that an analysis of FP-D will help to define the relationship between copia-like transposable elements and retroviruses.

Topical Corticosteroids : Clinical Pharmacology and Therapeutic Use

Miller, J.A.,Munro, D.D. Medical Publications Korea 1975 Medical Progress Vol.2 No.11

항공치과학

Miller, Samuel Charles,이석호 공군본부 의무감실 1969 항공의학 Vol.17 No.1-2

Historical Pitch in Korean and Janpanese

Miller, Roy Andrew 한국알타이학회 1989 알타이학보 Vol.1 No.1

How Do We Interpret the 'Bad News' About Cancer?

Miller, Ahthony B. MediMedia Korea 1994 JAMA-Korea Vol.9 No.8

THE ROLE OF ENVIRONMENT IN LOW-LEVEL ACTIVE GALACTIC NUCLEUS ACTIVITY: NO EVIDENCE FOR CLUSTER ENHANCEMENT

Miller, Brendan,Gallo, Elena,Treu, Tommaso,Woo, Jong-Hak IOP Publishing 2012 ASTROPHYSICAL JOURNAL LETTERS - Vol.745 No.1

<P>We use the AMUSE-Virgo and AMUSE-Field surveys for nuclear X-ray emission in early-type galaxies to conduct a controlled comparison of low-level supermassive black hole activity within cluster and field spheroids. While both the Virgo and the Field samples feature highly sub-Eddington X-ray luminosities (L-X/L-Edd between similar to 10(-8) and 10(-4)), we find that after accounting for the influence of host galaxy stellar mass, the field early-type galaxies tend toward marginally greater (0.38 +/- 0.14 dex) nuclear X-ray luminosities, at a given black hole mass, than their cluster counterparts. This trend is qualitatively consistent with the field black holes having access to a greater reservoir of fuel, plausibly in the form of cold gas located near the nucleus. We are able to rule out at high confidence the alternative of enhanced X-ray activity within clusters. Presuming nuclear X-ray emission correlates with the total energy and momentum output of these weakly accreting black holes, this indicates that low-level active galactic nucleus feedback is not generally stronger within typical cluster galaxies than in the field. These results confirm that for most cluster early-type galaxies (i.e., excluding brightest cluster galaxies) direct environmental effects, such as gas stripping, are more relevant in quenching star formation.</P>