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- 저자 : Bingmei Fu (검색결과 1 건)
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Computational Bio-Fluid Mechanics
Yang Liu,Weiwei Yan,Mingzhen Lu,Bingmei Fu 한국전산유체공학회 2014 한국전산유체공학회 학술대회논문집 Vol.2014 No.10
It has been found that both circulating blood cells and tumor cells are more easily adherent to curved microvessels than straight ones. In this paper, the hypothesis that tumor cells prefer to adhere at the microvessels with localized shear stresses and their gradients, such as in the curved microvessels, was examined both experimentally and computationally. The fluid dynamics was carried out by the lattice Boltzmann method (LBM), and the cell dynamics was governed by the Newton’s law of translation and rotation. The adhesive dynamics model is involved the effect of receptor-ligand bonds between circulating cells and endothelial cells (ECs). It was found that the wall shear stress/gradient, over a threshold, had significant contribution to tumor cell adhesion by activating or inactivating cell adhesion molecules. Our results elucidated why the tumor cell adhesion prefers to occur at the positive curvature of curved microvessels with very low Reynolds number (in the order of 10<SUP>-2</SUP>) laminar flow. Obstructive sleep apnea (OSA) is a common disorder characterized by partial or complete narrowing of the pharyngeal airway during sleep. The success rate of OSA surgery is very low, CFD is a good alternative tool to understand OSA pathophysiology. We have carried out both LES simulation and experimental measurement in real OSA upper airways for both before and after surgery, and a good agreement is achieved.
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