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РУССКАЯ ВЕРСИЯ РОМАНА ГЕНРИ МИЛЛЕРА 《ТРОПИК РАКА》
Т.А. Ромашова(T.A. Romashova),Л.А. Ахмыповская(L.A. Ahmylovskaya),А. Бепанова(A. Belanova) 동북아시아문화학회 2008 동북아시아문화학회 국제학술대회 발표자료집 Vol.- No.-
The article is devoted to translation transformations in fiction on the material of the novel "Tropic of cancer" by Henry Miller. The choice of the theme is influenced by the necessity to analyze ways of translation to achieve the adequate literary interpretation. The article submitted deals with one of the urgent problems of the theory of translation in fiction which concerns with the translation of the untranslatable.
Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis
Makarov, V.,Manina, G.,Mikusova, K.,Mollmann, U.,Ryabova, O.,Saint-Joanis, B.,Dhar, N.,Pasca, M. R.,Buroni, S.,Lucarelli, A. P.,Milano, A.,De Rossi, E.,Belanova, M.,Bobovska, A.,Dianiskova, P.,Kordula American Association for the Advancement of Scienc 2009 Science Vol.324 No.5928
<P>New drugs are required to counter the tuberculosis (TB) pandemic. Here, we describe the synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new class of antimycobacterial agents that kill Mycobacterium tuberculosis in vitro, ex vivo, and in mouse models of TB. Using genetics and biochemistry, we identified the enzyme decaprenylphosphoryl-beta-d-ribose 2'-epimerase as a major BTZ target. Inhibition of this enzymatic activity abolishes the formation of decaprenylphosphoryl arabinose, a key precursor that is required for the synthesis of the cell-wall arabinans, thus provoking cell lysis and bacterial death. The most advanced compound, BTZ043, is a candidate for inclusion in combination therapies for both drug-sensitive and extensively drug-resistant TB.</P>