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- 저자 : Beata Stankiewicz (검색결과 2 건)
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Beata Zielnik-Jurkiewicz,Wanda Stankiewicz-Szymczak 대한이비인후과학회 2016 Clinical and Experimental Otorhinolaryngology Vol.9 No.2
Objectives. The role of pro-inflammatory cytokines in the course of chronic otitis media with effusion (COME) has been documented. However, there are fewer studies on the action of anti-inflammatory cytokines in the middle ear. We sought determine whether there is an association between COME and anti-inflammatory cytokines and whether there are any differences in the cytokine profile in COME children with and without atopy. Methods. Eighty-four children were divided into 3 groups: 32 nonatopic children with COME (group NA), 31 atopic children with COME (group A), and 21 children without COME and without atopy (control group C). Specimens from the middle ear were collected and evaluated by enzyme-linked immunosorbent assay for the cytokines interleukin-1 receptor antagonist (IL-1Ra) and immunoregulatory IL-10. Results. Significantly higher IL-10 concentrations were found in both nonatopic and atopic children with COME compared to controls. No significant differences in IL-1Ra levels were found between atopic and nonatopic children with COME and the control group. Conclusion. We found no differences in the levels of IL-1Ra in atopic and nonatopic children with COME compared to controls. However, we found elevated IL-10 levels in the middle ear effusions from children with COME, with or without atopy. These elevated immunoregulatory cytokine levels suggest a role for new immunomodulatory treatments to prevent disease progression in COME, regardless of atopy.
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Structural evaluation of all-GFRP cable-stayed footbridge after 20 years of service life
Piotr Górski,Beata Stankiewicz,Marcin Tatara 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.29 No.4
The paper presents the study on a change in modal parameters and structural stiffness of cable-stayed Fiberline Bridge made entirely of Glass Fiber Reinforced Polymer (GFRP) composite used for 20 years in the fjord area of Kolding, Denmark. Due to this specific location the bridge structure was subjected to natural aging in harsh environmental conditions. The flexural properties of the pultruded GFRP profiles acquired from the analyzed footbridge in 1997 and 2012 were determined through three-point bending tests. It was found that the Young's modulus increased by approximately 9%. Moreover, the influence of the temperature on the storage and loss modulus of GFRP material acquired from the Fiberline Bridge was studied by the dynamic mechanical analysis. The good thermal stability in potential real temperatures was found. The natural vibration frequencies and mode shapes of the bridge for its original state were evaluated through the application of the Finite Element (FE) method. The initial FE model was created using the real geometrical and material data obtained from both the design data and flexural test results performed in 1997 for the intact composite GFRP material. Full scale experimental investigations of the free-decay response under human jumping for the experimental state were carried out applying accelerometers. Seven natural frequencies, corresponding mode shapes and damping ratios were identified. The numerical and experimental results were compared. Based on the difference in the fundamental natural frequency it was again confirmed that the structural stiffness of the bridge increased by about 9% after 20 years of service life. Data collected from this study were used to validate the assumed FE model. It can be concluded that the updated FE model accurately reproduces the dynamic behavior of the bridge and can be used as a proper baseline model for the long-term monitoring to evaluate the overall structural response under service loads. The obtained results provided a relevant data for the structural health monitoring of all-GFRP bridge.
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