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RISS 인기검색어
- 검색키워드
- 저자 : B?dard, Sabrina (검색결과 4 건)
- 무료
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Effects of upstream two-dimensional hills on design wind loads: A computational approach
Bitsuamlak, G.,Stathopoulos, T.,Bedard, C. Techno-Press 2006 Wind and Structures, An International Journal (WAS Vol.9 No.1
The paper describes a study about effects of upstream hills on design wind loads using two mathematical approaches: Computational Fluid Dynamics (CFD) and Artificial Neural Network (NN for short). For this purpose CFD and NN tools have been developed using an object-oriented approach and C++ programming language. The CFD tool consists of solving the Reynolds time-averaged Navier-Stokes equations and $k-{\varepsilon}$ turbulence model using body-fitted nearly-orthogonal coordinate system. Subsequently, design wind load parameters such as speed-up ratio values have been generated for a wide spectrum of two-dimensional hill geometries that includes isolated and multiple steep and shallow hills. Ground roughness effect has also been considered. Such CFD solutions, however, normally require among other things ample computational time, background knowledge and high-capacity hardware. To assist the enduser, an easier, faster and more inexpensive NN model trained with the CFD-generated data is proposed in this paper. Prior to using the CFD data for training purposes, extensive validation work has been carried out by comparing with boundary layer wind tunnel (BLWT) data. The CFD trained NN (CFD-NN) has produced speed-up ratio values for cases such as multiple hills that are not covered by wind design standards such as the Commentaries of the National Building Code of Canada (1995). The CFD-NN results compare well with BLWT data available in literature and the proposed approach requires fewer resources compared to running BLWT experiments.
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Generalization of wind-induced interference effects for two buildings
Khanduri, Atul C.,Stathopoulos, Theodore,Bedard, Claude Techno-Press 2000 Wind and Structures, An International Journal (WAS Vol.3 No.4
Wind-induced interference effects on a building are the result of one or more adjacent buildings modifying the flow of wind around it, which may result in a significant increase or decrease in wind loads on the building. Wind loading standards and codes of practice offer little guidance to the designer for assessing the effects of interference. Experimental results on interference effects indicate that code recommendations may be significantly low (unsafe) or uneconomically conservative. The paper presents results of an extensive experimental program to study the wind flow mechanisms and to quantify the extent of wind load modifications on buildings due to interference effects. These results have been simplified and presented from the point-of-view of design and codification for the case of two buildings. Based on these results, general guidelines and limiting conditions defining wind interference are formulated and discussed.
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ESR1 Mutation Detection and Dynamics in Meningeal Carcinomatosis in Breast Cancer
Marcela Carausu,Samia Melaabi,Jean-Yves Pierga,François-Clément Bidard,Luc Cabel 한국유방암학회 2020 Journal of breast cancer Vol.23 No.2
ESR1 mutation is frequently encountered in hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC), especially after aromatase inhibitor (AI) therapy, as a mechanism of resistance to endocrine therapy. Circulating tumor DNA-based detection of ESR1 mutation in plasma has been demonstrated as a prognostic and predictive factor for poor outcomes in subsequent AI therapy. In this case report, for the first time, we describe the detection of ESR1 mutation (p.Tyr537Ser) only in the cerebrospinal fluid (CSF) and not in the plasma of a patient with isolated leptomeningeal progression who was treated with AI for HR-positive, HER2-negative MBC (bone metastasis only). Circulating tumor DNA levels also appeared to be correlated with clinical evolution. We suggest that in the presence of isolated leptomeningeal metastasis and when tamoxifen or AI has been prescribed for HR-positive MBC, CSF should be screened for ESR1 mutations to potentially adjust systemic treatment.
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