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Chandrasekaran Karthikeyan,Kokkarachedu Varaprasad,Sungjun Kim,Ashok Kumar Jangid,Wonjeong Lee,Abdulrahman Syedahamed Haja Hameed,Kyobum Kim 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-
The new development of inorganic (IO) nanoparticle (NPs)-based nanomedicines in anticancer therapy isan active area of research. The cellular uptake of IO NPs plays a crucial role in their efficacy as anticanceragents. In this case, IO NPs cellular uptake depends on physical and chemical parameters, including size,shape, and surface modification of the nanoparticles. From the cellular uptake, one of the essentialparameters for small size plays a critical role in the NPs’ due to their ability to passively diffuse acrossthe cell membrane or enter cells through endocytosis. In this study, the inorganic SnO2 (tin dioxide)and SA (sodium alginate) were made into SnO2 (SASnO2) using a simple one-pot green method. Biomedical studies have shown that SASnO2 NPs exhibit greater antibacterial, antioxidant, and anticancerproperties than SnO2 NPs. The prepared SnO2 and SASnO2 NPs were tested against breast cancer cells inanticancer studies. In cellular uptake studies, the smaller size of SASnO2 NPs (19 nm) resulted in highercellular uptake compared to SnO2 NPs (38 nm). The larger surface area of these SASnO2 NPs allows formore contact with biological membranes and internalization (cell uptake) by cancer cells, resulting inenhanced anticancer therapy when using SASnO2 NPs.
Thambiannan Senthilkumar,Ashok K Bharimalla,Chandrasekaran Sundaramoorthy,Prashantkumar G Patil,Nadanathangam Vigneshwaran 한국섬유공학회 2020 Fibers and polymers Vol.21 No.9
The reinforcing potential of coconut fibers, fibrillated by mechanical refining process, in an epoxy matrix wasevaluated. The coconut fiber was fibrillated by a conical refiner for different duration (10 to 40 min) and subjected tochemical compositional analysis, size distribution by microscopy and crystallinity by XRD. The fibrillation by mechanicalrefining process did not affect the crystallinity of coconut fibers. But, cellulose content increased due to the removal of ligninduring refining process. The fibrillated coconut fiber (FCF) was used to reinforce epoxy resin by casting process. The meltingtemperature, as analyzed by DSC, of epoxy composites increased from 294.75 °C (epoxy alone) to 338.96 °C (raw coconutfiber, RCF) and a maximum of 353.41 °C for 20 min processed FCF reinforced composites. The surface resistivity of epoxycontrol increased from 1.32 e10 Ω to 22.6 e10 Ω after reinforcing with control coconut fiber. But, the fibrillation processreduced the surface resistivity due to uniform distribution of FCF in the epoxy matrix avoiding the formation of air voids. Similar trend was observed for volume resistivity also. The damage force and tensile load increased significantly for the FCFreinforced composites, 61 % and 12 %, respectively, when compared to the RCF reinforced composites. Hence, as analternative of conventional alkali treatment, fibrillation of coconut fibers could significantly improve the performance ofepoxy composites.
Meconium Peritonitis: A Rare Treatable Cause of Non-Immune Hydrops
Rajendran, Usha Devi,Govindarajan, Jeyanthi,Balakrishnan, Umamaheswari,Chandrasekaran, Ashok,Amboiram, Prakash The Korean Society of Pediatric Gastroenterology 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.6
Meconium peritonitis as a cause of non-immune hydrops in neonates is rarely reported. Here we report such a rare occurrence. In our case, a routine antenatal scan at 25 weeks revealed isolated ascites. By 31 weeks of gestation, all features of hydrops were observed in scans. However, antenatal workup for immune and non-immune hydrops was negative. Subsequently, a preterm hydropic female baby was delivered at 32 weeks. She required intubation and ventilator support. An X-ray revealed calcification in the abdomen suggestive of meconium peritonitis. Ultrasound showed gross ascites, a giant cyst compressing the inferior vena cava, and minimal bilateral pleural effusion. Emergency laparotomy revealed meconium pellets and perforation of the ileum. Double-barrel ileostomy was performed, and the edema resolved and activity improved. The baby was discharged after 3 weeks. Ileostomy closure was done at follow-up. The baby is growing well.
Meconium Peritonitis: A Rare Treatable Cause of Non-Immune Hydrops
Usha Devi Rajendran,Jeyanthi Govindarajan,Umamaheswari Balakrishnan,Ashok Chandrasekaran,Prakash Amboiram 대한소아소화기영양학회 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.6
Meconium peritonitis as a cause of non-immune hydrops in neonates is rarely reported. Here we report such a rare occurrence. In our case, a routine antenatal scan at 25 weeks revealed isolated ascites. By 31 weeks of gestation, all features of hydrops were observed in scans. However, antenatal workup for immune and non-immune hydrops was negative. Subsequently, a preterm hydropic female baby was delivered at 32 weeks. She required intubation and ventilator support. An X-ray revealed calcification in the abdomen suggestive of meconium peritonitis. Ultrasound showed gross ascites, a giant cyst compressing the inferior vena cava, and minimal bilateral pleural effusion. Emergency laparotomy revealed meconium pellets and perforation of the ileum. Double-barrel ileostomy was performed, and the edema resolved and activity improved. The baby was discharged after 3 weeks. Ileostomy closure was done at follow-up. The baby is growing well.