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韓國における日本ドラマを用いた日本語敎育の實踐報告 -學習者のレベル差が大きいクラスを對象に-

( Asaga Tomoe ) 한국일본어교육학회 2011 日本語敎育 Vol.55 No.-
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  KCI
  
  KISS
本稿は敎室內で學習者の日本語のレベル差が大きい場合に、效果的な敎室活動を探ることを目的に、韓國人學習者を對象に日本ドラマを用いた授業の實踐報告を行った。日本ドラマを敎材として用いた日本語敎育の報告はこれまでにも見られるが、その多くは中級以上の學習者が對象であり、レベル差の大きいクラスを對象とした報告は見當たらない。そこで本稿では「日本ドラマ」の授業の受講者にアンケ―トを行い、授業で行った活動の滿足度を調査した。學習者を初步、初級、中·上級のレベル別に調査結果を分析したところ、敎室活動の中には、學習者の日本語レベルによって滿足度が異なるものがあることが明らかになった。敎師は學習者のレベルによって好まれる活動を把握し、それらをバランスよく取り入れることで、レベル差が大きいクラスにおいて學習者に滿足度の高い授業を行うことができる。また、授業全體としての學習者の滿足度は高かったことから、レベル差が大きいクラスにおいても日本ドラマを用いた敎室活動の有效性を示せたと言える。
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Developmental and age-related changes of peptidylarginine deiminase 2 in the mouse brain

Shimada, Nobuko,Handa, Setsuko,Uchida, Yoshiaki,Fukuda, Mitsugu,Maruyama, Naoki,Asaga, Hiroaki,Choi, Eun-Kyoung,Lee, Jaewon,Ishigami, Akihito Wiley Subscription Services, Inc., A Wiley Company 2010 Journal of neuroscience research Vol.88 No.4
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Peptidylarginine deiminases (PADs) are a group of posttranslational modification enzymes that citrullinate (deiminate) protein arginine residues in a Ca2+-dependent manner. Enzymatic citrullination abolishes positive charges of native protein molecules, inevitably causing significant alterations in their structure and functions. Among the five isoforms of PADs, PAD2 and PAD4 are proved occupants of the central nervous system (CNS), and especially PAD2 is a main PAD enzyme expressed in the CNS. We previously reported that abnormal protein citrullination by PAD2 has been closely associated with the pathogenesis of neurodegenerative disorders such as Alzheimer's disease and prion disease. Protein citrullination in these patients is thought to play a role during the initiation and/or progression of disease. However, the contribution of changes in PAD2 levels, and consequent citrullination, during developmental and aging processes remained unclear. Therefore, we used quantitative real-time RT-PCR, Western blot analysis, and immunohistochemical methods to measure PAD2 expression and localization in the brain during those processes. PAD2 mRNA expression was detected in the brains of mice as early as embryonic day 15, and its expression in cerebral cortex, hippocampus, and cerebellum increased significantly as the animals aged from 3 to 30 months old. No citrullinated proteins were detected during that period. Moreover, we found here, for the first time, that PAD2 localized specifically in the neuronal cells of the cerebral cortex and Purkinje cells of the cerebellum. These findings indicate that, despite PAD2's normally inactive status, it becomes active and citrullinates cellular proteins, but only when the intracellular Ca2+ balance is upset during neurodegenerative changes. © 2009 Wiley-Liss, Inc.