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Hassan M. Khan,Andrew D. Fraser,Steven Daws,Jaisri Thoppay,Mel Mupparapu 대한영상치의학회 2018 Imaging Science in Dentistry Vol.48 No.1
Historically, Eagle syndrome is a term that has been used to describe radiating pain in the orofacial region, foreign body sensation, and/or dysphagia due to a unilateral or bilateral elongated styloid process impinging upon the tonsillar region. Because elongated styloid processes-with or without associated Eagle syndrome-can present with various symptoms and radiographic findings, it can be challenging for healthcare practitioners to formulate an accurate diagnosis. Abnormal styloid anatomy can lead to a multitude of symptoms, including chronic orofacial/neck pain, thus masquerading as more commonly diagnosed conditions. In this report, we describe a patient who presented to our department with styloid process elongation and fracture. A careful history, physical examination, and a conebeam computed tomography (CBCT) investigation led to the diagnosis. The patient was then referred for appropriate care. This case report demonstrates the utilization of CBCT in differentiating a fracture site from a pseudo-joint that might mimic a fracture.
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Khan, Hassan M.,Fraser, Andrew D.,Daws, Steven,Thoppay, Jaisri,Mupparapu, Mel Korean Academy of Oral and Maxillofacial Radiology 2018 Imaging Science in Dentistry Vol.48 No.1
Historically, Eagle syndrome is a term that has been used to describe radiating pain in the orofacial region, foreign body sensation, and/or dysphagia due to a unilateral or bilateral elongated styloid process impinging upon the tonsillar region. Because elongated styloid processes-with or without associated Eagle syndrome-can present with various symptoms and radiographic findings, it can be challenging for healthcare practitioners to formulate an accurate diagnosis. Abnormal styloid anatomy can lead to a multitude of symptoms, including chronic orofacial/neck pain, thus masquerading as more commonly diagnosed conditions. In this report, we describe a patient who presented to our department with styloid process elongation and fracture. A careful history, physical examination, and a cone-beam computed tomography (CBCT) investigation led to the diagnosis. The patient was then referred for appropriate care. This case report demonstrates the utilization of CBCT in differentiating a fracture site from a pseudo-joint that might mimic a fracture.
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Alex Barnes,Jane M Andrews,Sutapa Mukherjee,Robert V Bryant,Peter Bampton,Robert J. Fraser,Réme Mountifield 대한장연구학회 2024 Intestinal Research Vol.22 No.1
Background/Aims: Insomnia is common in people with chronic medical conditions, such as inflammatory bowel disease (IBD), and is readily treatable through cognitive behavioral therapy for insomnia. This study aimed to describe the associations with insomnia in people with IBD and its relationship to IBD-related disability.Methods: An online questionnaire was administered through 3 tertiary IBD centers, social media, and Crohn’s Colitis Australia. The questionnaire included the Insomnia Severity Index (ISI), a validated assessment of insomnia. Measures of anxiety, depression, physical activity, and disability were also included. IBD activity was assessed using validated patient reported scores. A multivariate model was constructed for clinically significant insomnia and ISI scores. Subpopulations of Crohn’s disease and ulcerative colitis were considered.Results: In a cohort of 670 respondents the median age was 41 years (range, 32–70 years), with the majority female (78.4%), the majority had Crohn’s disease (57.3%). Increasingly severe disability was associated with worse insomnia score. Clinically significant insomnia was associated with clinically active IBD, abdominal pain, anxiety, and depression, in a multivariate model. In an ulcerative colitis population, Simple Clinical Colitis Activity Index components of general well-being and urgency were associated with worse ISI score in a model including depression and anxiety. In those with Crohn’s disease, the multivariate model included Harvey Bradshaw Index score in addition to depression and anxiety.Conclusions: Insomnia is common in people with IBD and is associated with increased disability. Abdominal pain and mental health conditions should prompt consideration for screening for insomnia and referral for cognitive behavioral therapy for insomnia.
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Cho, Kwangsoo,O’Neill, Carmel M.,Kwon, Soo-Jin,Yang, Tae-Jin,Smooker, Andrew M.,Fraser, Fiona,Bancroft, Ian Blackwell Publishing Ltd 2010 The Plant journal Vol.61 No.4
<P>Summary</P><P>We conducted a sequence-level comparative analyses, at the scale of complete bacterial artificial chromosome (BAC) clones, between the genome of the most economically important <I>Brassica</I> species, <I>Brassica napus</I> (oilseed rape), and those of <I>Brassica rapa</I>, the genome of which is currently being sequenced, and <I>Arabidopsis thaliana</I>. We constructed a new <I>B. napus</I> BAC library and identified and sequenced clones that contain homoeologous regions of the genome including stearoyl-ACP desaturase-encoding genes. We sequenced the orthologous region of the genome of <I>B. rapa</I> and conducted comparative analyses between the <I>Brassica</I> sequences and those of the orthologous region of the genome of <I>A. thaliana</I>. The proportion of genes conserved (∼56%) is lower than has been reported previously between <I>A. thaliana</I> and <I>Brassica</I> (∼66%). The gene models for sets of conserved genes were used to determine the extent of nucleotide conservation of coding regions. This was found to be 84.2 ± 3.9% and 85.8 ± 3.7% between the <I>B. napus</I> A and C genomes, respectively, and that of <I>A. thaliana</I>, which is consistent with previous results for other <I>Brassica</I> species, and 97.5 ± 3.1% between the <I>B. napus</I> A genome and <I>B. rapa</I>, and 93.1 ± 4.9% between the <I>B. napus</I> C genome and <I>B. rapa</I>. The divergence of the <I>B. napus</I> genes from the A genome and the <I>B. rapa</I> genes was greater than anticipated and indicates that the A genome ancestor of the <I>B. napus</I> cultivar studied was relatively distantly related to the cultivar of <I>B. rapa</I> selected for genome sequencing.</P>
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