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RISS 인기검색어
- 검색키워드
- 저자 : Andrea Esposito (검색결과 2 건)
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P<sub>D</sub>SO tuning of PFC-SAC fault tolerant flight control system
Alaimo, Andrea,Esposito, Antonio,Orlando, Calogero Techno-Press 2019 Advances in aircraft and spacecraft science Vol.6 No.5
In the design of flight control systems there are issues that deserve special consideration and attention such as external perturbations or systems failures. A Simple Adaptive Controller (SAC) that does not require a-priori knowledge of the faults is proposed in this paper with the aim of realizing a fault tolerant flight control system capable of leading the pitch motion of an aircraft. The main condition for obtaining a stable adaptive controller is the passivity of the plant; however, since real systems generally do not satisfy such requirement, a properly defined Parallel Feedforward Compensator (PFC) is used to let the augmented system meet the passivity condition. The design approach used in this paper to synthesize the PFC and to tune the invariant gains of the SAC is the Population Decline Swarm Optimization ($P_DSO$). It is a modification of the Particle Swarm Optimization (PSO) technique that takes into account a decline demographic model to speed up the optimization procedure. Tuning and flight mechanics results are presented to show both the effectiveness of the proposed $P_DSO$ and the fault tolerant capability of the proposed scheme to control the aircraft pitch motion even in presence of elevator failures.
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Calorie Restriction for Cancer Prevention and Therapy: Mechanisms, Expectations, and Efficacy
Chiara Vidoni,Alessandra Ferraresi,Andrea Esposito,Chinmay Maheshwari,Danny N. Dhanasekaran,Vincenzo Mollace,Ciro Isidoro 대한암예방학회 2021 Journal of cancer prevention Vol.26 No.4
Cancer is one of the most frequently diagnosed diseases, and despite the continuous efforts in searching for new and more effective treatments, its morbidity and mortality remain a significant health problem worldwide. Calorie restriction, a dietary manipulation that consists in a reduction of the calorie intake, is gaining attention as a potential adjuvant intervention for preventing and/ or fighting cancer. Several forms of energy reduction intake, which includes caloric restriction tout-court, dietary restrictions, and intermittent fasting, are being explored for their ability to prevent or slow down cancer progression. Additionally, another anti-cancer approach being under investigation relies on the use of nutraceuticals known as “Caloric Restriction Mimetics” that can provide caloric restriction-mediated benefits without subjecting the patients to a strict diet. Preclinical in vitro and in vivo studies consistently show that diet modifiers reducing the calorie have impact on tumor microenvironment and cancer metabolism, resulting in reduced growth and progression of cancer. Preliminary clinical studies show that patients subjected to a reduced nutrient/energy intake experience improved outcomes from chemo- and radiotherapy while better tolerating the side effects. Here, we review the state of the art on the therapeutic potential of calorie restriction and of caloric restriction mimetics in preventing or retarding tumor development by modulating a subset of cellular processes. The most recent clinical progresses with caloric restriction mimetics in the clinical practice are also discussed.
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