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RISS 인기검색어
- 검색키워드
- 저자 : Anandrao R. Kulkarni (검색결과 4 건)
- 무료
- 기관 내 무료
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Development and evaluation of psyllium seed husk polysaccharide based wound dressing films
Patil, Basavaraj S.,Mastiholimath, Vinayak S.,Kulkarni, Anandrao R. 경희한의학연구센터 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.2
In the present study, wound dressing films were fabricated using Seed Husk of Psyllium (SHP) complexed with povidone iodine and were evaluated for various physicochemical properties as well as wound healing activity in albino rats. The required film properties for the successful wound dressings, such as film elongation (elasticity), tensile strength, water uptake and water vapor transmission rates (WVTR) were examined. Results indicated that SHP films showed good elasticity (80.27-116.24%) and acceptable tensile strengths (8.33-22.13 N/$^mm2$). SHP films were evaluated for water absorption pattern as well as permeation to water vapours and results showed that films were able to swell in water upto 167 to 191% w/w and WVTR were in the range between $8.23{\times}10^{-3}$ to $1.12{\times}10^{-4}g.cm^2/day$. Selected formulation of SHP films with optimum characteristics were loaded with Povidone iodine (PI) solution by soaking method and were evaluated for antimicrobial and wound healing activity on excision wound model. Results indicated that PI loaded films showed significant antibacterial activity against both gram positive and gram negative selected bacteria. PI loaded SHP films showed comparatively better wound healing property to control group with faster epithelialization and greater rates of wound contraction.
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Development and evaluation of psyllium seed husk polysaccharide based wound dressing films
Basavaraj S. Patil,Vinayak S. Mastiholimath,Anandrao R. Kulkarni 경희대학교 융합한의과학연구소 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.2
In the present study, wound dressing films were fabricated using Seed Husk of Psyllium (SHP) complexed with povidone iodine and were evaluated for various physicochemical properties as well as wound healing activity in albino rats. The required film properties for the successful wound dressings, such as film elongation (elasticity), tensile strength, water uptake and water vapor transmission rates (WVTR) were examined. Results indicated that SHP films showed good elasticity (80.27–116.24%) and acceptable tensile strengths (8.33–22.13 N/mm2). SHP films were evaluated for water absorption pattern as well as permeation to water vapours and results showed that films were able to swell in water upto 167 to 191% w/w and WVTR were in the range between 8.23×10−3 to 1.12×10−4 g.cm2/day. Selected formulation of SHP films with optimum characteristics were loaded with Povidone iodine (PI) solution by soaking method and were evaluated for antimicrobial and wound healing activity on excision wound model. Results indicated that PI loaded films showed significant antibacterial activity against both gram positive and gram negative selected bacteria. PI loaded SHP films showed comparatively better wound healing property to control group with faster epithelialization and greater rates of wound contraction.
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Boswellic acid suppresses cyclophosphamide induced chromosomal damage in mice
Kuntal Ganguly,N. V. Jagadeesh,Rakesh Singh,B. S. Thippeswami,Ashok D. Taranalli,Anandrao R. Kulkarni 경희대학교 융합한의과학연구소 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.3
This study was performed to determine whether Boswellic acid suppresses genotoxicity induced by cyclophosphamide in mice. Genotoxicity was induced by the administration of cyclophosphamide (50 mg/kg) in swiss albino mice and was measured by counting the number of micronuclei and observing chromosomal aberration. In test group Boswellic acid was given in the dose of 200 mg/kg and various chromosomal aberration and formation of micronuclei were observed. Boswellic acid in dose of 200 mg/kg significantly (P<0.001) inhibited the cyclophosphamide induced micronucleus formation and also significantly (P<0.001) inhibited chromosomal aberrations in mice. Whereas Boswellic acid alone did not either induce formation of micronuclei or chromosomal aberration in mice. Boswellic acid itself doesn’t have any genotoxic effect and suppresses genotoxicity induced by cyclophosphamide.
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Boswellic acid suppresses cyclophosphamide induced chromosomal damage in mice
Ganguly, Kuntal,Jagadeesh, N.V.,Singh, Rakesh,Thippeswami, B.S.,Taranalli, Ashok D.,Kulkarni, Anandrao R. 경희한의학연구센터 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.3
This study was performed to determine whether Boswellic acid suppresses genotoxicity induced by cyclophosphamide in mice. Genotoxicity was induced by the administration of cyclophosphamide (50 mg/kg) in swiss albino mice and was measured by counting the number of micronuclei and observing chromosomal aberration. In test group Boswellic acid was given in the dose of 200 mg/kg and various chromosomal aberration and formation of micronuclei were observed. Boswellic acid in dose of 200 mg/kg significantly ($P$ <0.001) inhibited the cyclophosphamide induced micronucleus formation and also significantly ($P$ <0.001) inhibited chromosomal aberrations in mice. Whereas Boswellic acid alone did not either induce formation of micronuclei or chromosomal aberration in mice. Boswellic acid itself doesn't have any genotoxic effect and suppresses genotoxicity induced by cyclophosphamide.
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