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- 검색키워드
- 저자 : Al-Abbadi, Abdullah (검색결과 2 건)
- 무료
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Bodoor, Khaldon,Haddad, Yazan,Alkhateeb, Asem,Al-Abbadi, Abdullah,Dowairi, Mohammad,Magableh, Ahmad,Bsoul, Nazzal,Ghabkari, Abdulhameed Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1
Aberrant DNA methylation of tumor suppressor genes has been reported in all major types of leukemia with potential involvement in the inactivation of regulatory cell cycle and apoptosis genes. However, most of the previous reports did not show the extent of concurrent methylation of multiple genes in the four leukemia types. Here, we analyzed six key genes (p14, p15, p16, p53, DAPK and TMS1) for DNA methylation using methylation specific PCR to analyze peripheral blood of 78 leukemia patients (24 CML, 25 CLL, 12 AML, and 17 ALL) and 24 healthy volunteers. In CML, methylation was detected for p15 (11%), p16 (9%), p53 (23%) and DAPK (23%), in CLL, p14 (25%), p15 (19%), p16 (12%), p53 (17%) and DAPK (36%), in AML, p14 (8%), p15 (45%), p53 (9%) and DAPK (17%) and in ALL, p15 (14%), p16 (8%), and p53 (8%). This study highlighted an essential role of DAPK methylation in chronic leukemia in contrast to p15 methylation in the acute cases, whereas TMS1 hypermethylation was absent in all cases. Furthermore, hypermethylation of multiple genes per patient was observed, with obvious selectiveness in the 9p21 chromosomal region genes (p14, p15 and p16). Interestingly, methylation of p15 increased the risk of methylation in p53, and vice versa, by five folds (p=0.03) indicating possible synergistic epigenetic disruption of different phases of the cell cycle or between the cell cycle and apoptosis. The investigation of multiple relationships between methylated genes might shed light on tumor specific inactivation of the cell cycle and apoptotic pathways.
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Ibrahim E. Helal,Hatim A. Al-Abbadi,Mohamed H. El-Daharawy,Mahmoud F. Ahmed 한국축산학회 2022 한국축산학회지 Vol.64 No.5
Delayed healing associated with distal limb wounds is highly challenging in equine clinicalpractice. This study aimed to evaluate healing rates between chronic non-granulatingwounds of horse distal limbs that were treated with maltodextrin/ascorbic acid gel alone orin combination with povidone-iodine 1% solution and those treated with povidone-iodine 1%only throughout the study period (35 days) in clinical settings. The study was conducted on18 adult horses (3–15 years old). Based on the treatment regimen utilized, the horses weredivided into three groups (n = 6), with each group having a similar mean wound area. Thepercentages of wound contraction, epithelialization, and overall wound healing were determinedweekly for each wound. By the end of the study, the total wound healing percentagewas significantly increased between the study groups (p < 0.05). The use of maltodextrin/ascorbic acid gel resulted in considerable wound contraction, rapid epithelialization, and complication-free wound healing. Based on the findings of this study, maltodextrin/ascorbic acidgel, independently or in combination with a 1% povidone-iodine solution, might be applied asa safe and effective wound healing promoting agent in horses with chronic non-granulatingwounds.
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