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      저자 : Afruz Haq (검색결과 1 건)
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        Effect of Honey on Antibody Production Against Thymus-Dependent and Thymus-Independent Antigens in Primary and Secondary Immune Responses

        Noori S. Al-Waili,Afruz Haq 한국식품영양과학회 2004 Journal of medicinal food Vol.7 No.4

        The objective was to study the effect of natural pure honey on the antibody production against thymus-de-pendent antigen [sheep red blood cells (SRBCs)] and thymus-independent antigen (Escherichia coli) in mice. Forty-two mice(mean weight 28.33. 3.44 g) were divided into two groups: group A (21 mice) fed regular diet and group B (21 mice) fedregular diet plus 0.8 g/kg of body weight/day of honey administered in four equally divided doses. Each animal was injectedintraperitoneally with 0.1 mL of 5% SRBCs and 0.1 mL of killed E. coli. The same dose of both antigens was given after 17days. At days 7 and 16 after primary immunization and at day 4 after secondary immunization, blood samples were collectedfrom seven mice at each time interval from group A and group B to estimate antibody titer using the hemoaggulination test.At day 7 after primary immunization, the mean antibody titer against SRBCs was 9.14. 3.02 in group A and 13.7. 3.9 ingroup B (P. .05), while the mean antibody titer against E. coliwas 14.8. 8.5 in group A and 14.8. 9.35 in group B. Atday 16, the mean antibody titer against SRBCs was 13.71. 3.9 in group A and 20. 9.8 in group B, while the mean anti-body titer against E. coliwas 14.69. 935 in group A and 26.67. 8.26 in group B (P. .05). Four days after secondary im-munization, the mean antibody titer against SRBCs was 13.33. 4.62 in group A and 16. 8.7 in group B, while the meanantibody titer against E. coliwas 42.67. 18.4 in group A and 69.33. 31.4 in group B. It might be concluded that oral honeystimulates antibody production during primary and secondary immune responses against thymus-dependent and thymus-independent antigens.

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