http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Ademola C. Famurewa (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Ademola C. Famurewa,Abiola M. Folawiyo,Elizabeth B. Enohnyaket,Sharon O. Azubuike-Osu,Innocent Abi,Sunday G. Obaje,Opeyemi A. Famurewa 한국한의학연구원 2018 Integrative Medicine Research Vol.7 No.3
Background: Methotrexate (MTX) is a commonly used antineoplastic and anti-rheumatoid agent whose efficacy is limited by marked organ toxicities associated with oxidative stress. The study investigated beneficial effect of virgin coconut oil (VCO) supplementation on MTX-induced oxidative stress and inflammation in rats. Methods: Rats were divided into 4 groups (n = 6): Control, MTX (20 mg/kg bw), VCO (5%) + MTX and VCO (15%) + MTX. The pre-treatment with VCO for 14 days was followed by single intraperitoneal injection of MTX and the rats were sacrificed after 3 days. Serum activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), and levels of reduced glutathione (GSH) and malondialdehyde (MDA) were determined. Interleukin-6 (IL-6), C-reactive protein (CRP) and nitric oxide (NO) levels were also evaluated. Results: MTX induced a distinct diminution in serum activities of oxidative stress markers (SOD, CAT, GPx and GSH), while lipid peroxidation considerably increased demonstrated by MDA level. Similarly, levels of IL-6, CRP and NO increased prominently in MTX control rats. The VCO supplementation markedly enhanced resistance to the MTX-induced biochemical alterations in rats. Conclusion: VCO can be a useful adjuvant natural product in MTX chemotherapy by reducing oxidative stress and pro-inflammatory responses.
-
Ayodeji J. Ajibare,Olabode O. Akintoye,Ademola C. Famurewa,Moshood A. Folawiyo,Olawande D. Bamisi,Abraham Olufemi Asuku,Oyedoyin Eunice Oyegbola,Christopher O. Akintayo,Babatunde A. Olofinbiyi,Olaposi 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.9
Polycystic ovarian syndrome (PCOS) is an endocrine disorder in women’s reproductive age. Currently, thepathophysiology of PCOS is unclear, and the limited treatment options are unsatisfactory. Virgin coconut oil (VCO) isfunctional food oil associated with pharmacological effects in reproductive disorders. Therefore, we aimed to evaluatewhether VCO could enhance clomiphene (CLO) therapy against PCOS in female rats. Rats were randomly divided: (1)Control, (2) PCOS model, (3) PCOS + CLO, (4) PCOS + VCO, and (5) PCOS + CLO + VCO. The PCOS was induced viadaily letrozole (1 mg/kg, orally) administration for 21 days. After the PCOS induction, CLO, VCO, and CLO + VCO wereadministered from days 22 to 36. Serum levels of gonadotropin-releasing hormone (GnRH), follicle-stimulating hormone(FSH), luteinizing hormone (LH), testosterone, estrogen, progesterone, and prolactin were estimated. Polymerase chainreaction gene expression for nuclear factor-erythroid-related factor 2, heme oxygenase-1 (HO-1), catalase (CAT), glutathionereductase (GSR), LH receptor (LHr), androgen receptor (AR), tumor necrosis factor-alpha (TNF-a), interleukin-1b (IL-1b),and caspase-3 were analyzed. The letrozole-induced PCOS caused considerable increases in GnRH, LH, prolactin, estrogen,and testosterone, whereas FSH decreased significantly compared to the control. The gene expression of Nrf2, HO-1, CAT, andGSR were markedly diminished, while IL-1b, TNF-a, caspase-3, AR, and LHr prominently increased compared to control. Interestingly, the CLO and VCO separately exerted anti-inflammatory and endocrine balance effects. However, VCOenhancedCLO effect in LH, prolactin and testosterone, Nrf2, HO-1, CAT, GSR, and AR. VCO may synergize with CLO todepress hyperandrogenism and oxidative inflammation in PCOS.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
