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- 저자 : Abhilash Vasanth (검색결과 1 건)
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Abhilash Vasanth,Shilpa M Patel,Ruchi Arora,Chetana D Parekh,Pariseema Dave,Bijal M Patel,Priyanka Vemanamandhi 대한부인종양학회 2024 Journal of Gynecologic Oncology Vol.35 No.2
Objective: To study clinical characters and outcomes in patients of malignant ovarian germcell tumor (MOGCT) undergoing surger y following neoadjuvant chemotherapy (NACT). Methods: Retrospective study of patients undergoing surger y following NACT for MOGCT atour institute. Platinum based chemotherapy was given in all patients in NACT. Results: Between March 2013 and Februar y 2023, 30 patients had surger y after NACT. Patient’s median age was 22 years (range, 12 to 35 years) and median follow up 42months(range, 6 to 132 months). Majority had endodermal sinus tumor (n=12), dysgerminoma (n=9)and mixed GCT (n=7). All had either International Federation of Gynecology and Obstetrics(FIGO) stage 3 (n=19) or FIGO stage 4 disease (n=11). Complete response to NACT seen in5 patients and 23 patients had partial response. Fertility sparing surger y in 18 patients andcomplete surger y in 12 patients. Suboptimal surger y was seen in 4 patients. Currently, 20of 30 patients are alive and disease free, 3 lost for follow up and 7 patients had progressionafter adjuvant therapy. Five patients had mortality—4 with progression and 1 with bleomycintoxicity. Fifteen of 17 eligible patients have resumed menstruation and one had successfulpregnancy. Prognostic factors noted in study are stage, optimal surger y and viable tumor inhistopathology. Dysgerminoma had better outcome than other histology. Conclusion: NACT may be a reasonable option in patients with extensive unresectable diseaseor in whom fertility sparing is not possible or in the poor general condition. Fertility sparingsurger y can be attempted post neoadjuvant chemotherapy without adversely affecting prognosis.
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