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- 저자 : Abbas Montazeri (검색결과 2 건)
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Arash Kardani,Abbas Montazeri,Herbert M. Urbassek 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.8
In recent years, tantalum (Ta)-based nanostructured dental implants have been widely utilized considering their exceptional biocompatibility, bioactivity, and biomechanical properties. Despite their advantages, the mechanical properties of Ta are higher than those of the adjacent jawbone, weakening the bone structure. It has been demonstrated that soft antibacterial additives such as copper (Cu) nanoparticles can tune the mechanical features of Ta-based implants to be similar to those of the adjacent bone. However, a noticeable gap in this research area is the lack of a computational model to explore the interfacial load transfer through the curved interfaces of Ta/Cu nanocomposites. Accordingly, a series of molecular dynamics simulations is employed to survey the microstructural evolution in Ta/Cu nanocomposites subjected to the uniaxial tensile loading condition at the body temperature. Additionally, to provide a complete picture of the contribution of Cu nanoparticles to the results, the mechanisms governing the plastic deformation of nanocomposite models with fine-grained and coarse-grained Ta matrix is systematically examined during the process. In summary, this work provides a comprehensive molecular dynamics simulation of the role of dislocation networks, twin formation, and their mutual interactions on the extent of the plastic zone in various Ta/Cu nanocomposite models.
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Generation of Scalable Hepatic Micro-Tissues as a Platform for Toxicological Studies
Darakhshan Sara,Bidmeshki Pour Ali,Kowsari-Esfahan Reza,Vosough Massoud,Montazeri Leila,Ghanian Mohammad Hossein,Baharvand Hossein,Piryaei Abbas 한국조직공학과 재생의학회 2020 조직공학과 재생의학 Vol.17 No.4
Background: Currently, there is an urgent need for scalable and reliable in vitro models to assess the effects of therapeutic entities on the human liver. Hepatoma cell lines, including Huh-7, show weakly resemblance to human hepatocytes, limiting their significance in toxicity studies. Co-culture of hepatic cells with non-parenchymal cells, and the presence of extracellular matrix have been shown to influence the biological behavior of hepatocytes. The aim of this study was to generate the scalable and functional hepatic micro-tissues (HMTs). Methods: The size-controllable HMTs were generated through co-culturing of Huh-7 cells by mesenchymal stem cells and human umbilical vein endothelial cells in a composite hydrogel of liver-derived extracellular matrix and alginate, using an air-driven droplet generator. Results: The generated HMTs were functional throughout a culture period of 28 days, as assessed by monitoring glycogen storage, uptake of low-density lipoprotein and indocyanine green. The HMTs also showed increased secretion levels of albumin, alpha-1-antitrypsin, and fibrinogen, and production of urea. Evaluating the expression of genes involved in hepatic-specific and drug metabolism functions indicated a significant improvement in HMTs compared to two-dimensional (2D) culture of Huh-7 cells. Moreover, in drug testing assessments, HMTs showed higher sensitivity to hepatotoxins compared to 2D cultured Huh-7 cells. Furthermore, induction and inhibition potency of cytochrome P450 enzymes confirmed that the HMTs can be used for in vitro drug screening. Conclusion: Overall, we developed a simple and scalable method for generation of liver micro-tissues, using Huh-7, with improved hepatic-specific functionality, which may represent a biologically relevant platform for drug studies.
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