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V.C. Sgarbieri,C.F. Rosaneli,A.E. Bighetti,M.A. Ant?io,J.E. Carvalho 한국식품영양과학회 2002 Journal of medicinal food Vol.5 No.4
The purpose of this research was to test the ability of a whey protein concentrate (WPC) toinhibit gastric mucosal ulcerative lesions caused by oral administration to rats of absoluteethanol. Acute administration (single doses) of WPC resulted in 41% inhibition of the ulcer-ative lesion index (ULI), and 73% inhibition was obtained with repetitive doses. In a 10-dayssubchronic treatment study, the inhibition was 64%, all relative to a saline treatment (nega-tive control). Alkylation of sulfhydryl compounds by subcutaneous injection of N-ethyl-maleimide essentially eliminated the WPC protection. Treating the rats with an intraperi-toneal injection of butathionine sulfoximine, which inhibits glutathione synthesis, reducedWPC protection to 35% and 52% for single and double doses, respectively. Taken as a whole,the results indicate that WPC does protect gastric mucosa from ethanol damage and that theprotection depends on sulfhydryl compounds present in the WPC, including its capacity tostimulate glutathione synthesis.21
C.F. Rosaneli,A.E. Bighetti,M.A. Antonio,J.E. Carvalho,V.C. Sgarbieri 한국식품영양과학회 2004 Journal of medicinal food Vol.7 No.3
The protective effect of a whey protein concentrate (WPC) was studied in three models of stomach ulcerative lesions induction: subcutaneous injection of indomethacin, and stress induced by either intraperitoneal injection of reserpine, or immobilization and holding in the cold (4 degrees C, 2 hours). Adult Wistar rats (300-400 g) were used for acute (single-dose), repetitive, or subchronic (10 days) administration of WPC prior to treatment with the ulcerogenic factors. The best protection was achieved in the indomethacin model for repetitive and subchronic experiments, reaching 50.1% and 44%, respectively, inhibition of the ulcerative lesions, which was significant at 1% probability (P <.01). For the immobilization and cold model, maximum inhibition by WPC was 22.1%, and that for the reserpine model was 23.8%. In both models the inhibition was not significant (P >.05) compared with saline (negative control).