Interleukin-12 and Interleukin-6 Gene Polymorphisms and Risk of Bladder Cancer in the Iranian Population

Ebadi, Nader,Jahed, Marzieh,Mivehchi, Mohamad,Majidizadeh, Tayebeh,Asgary, Mojgan,Hosseini, Seyed Ali Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18

Interleukin-12 (IL-12) as an antitumor and interleukin-6 (IL-6) as an inflammatory cytokine, are immunomodulatory products that play important roles in responses in cancers and inflammation. We tested the association between two polymorphisms of IL-12(1188A>C; rs3212227) and IL-6 (-174 C>G) and the risk of bladder cancer in 261 patients and 251 healthy individuals. We also investigated the possible association of these SNPs in patients with high-risk jobs and smoking habits with the incidence of bladder cancer. The genotype distributions of IL-6 (-174 C/G) genotype were similar between the cases and the control groups; however, among patients with smoking habits, the association between IL-6 gene polymorphism and incidence of bladder cancer was significant. After a control adjustment for age and sex, the following results were recorded: CC genotype (OR= 2.11, 95%CI=1.56-2.87, p=0.007), GC genotype (OR=2.18, 95%CI=1.16-4.12, p=0.014) and GC+CC (OR=2.6, 95%CI=1.43-4.47, p=0.011). A significant risk of bladder cancer was observed for the heterozygous genotype (AC) of IL-12 (OR=1.47, 95%CI=1.01-2.14, p=0.045) in all cases, and among smokers (AC) (OR=3.13, 95%CI=1.82-5.37, p=0.00014), combined AC+CC (OR=3.05, 95%CI=1.8-5.18, p=0.000015). Moreover among high risk job patients, there was more than a 3-fold increased risk of cancer in the carriers of IL-12 beta heterozygous (OR=3.7, 95%CI=2.04-6.57, p=0.000056) and combined AC+CC(OR=3.29, 95%CI=1.58-5.86, p=0.00002) genotypes as compared with the AA genotype with low-risk jobs. As a conclusion, this study suggests that IL-12(3'UTR A>C) and IL-6 (-174 C>G) genotypes are significantly associated with an increased risk of bladder cancer in the Iranian population with smoking habits and/or performing high-risk jobs.

Soft story retrofit of low-rise braced buildings by equivalent moment-resisting frames

Parviz Ebadi,Ahmad Maghsoudi,Hessam Mohamady 국제구조공학회 2018 Structural Engineering and Mechanics, An Int'l Jou Vol.68 No.5

Soft-story buildings have bottom stories much less rigid than the top stories and are susceptible to earthquake damage. Therefore, the seismic design specifications need strict design considerations in such cases. In this paper, a four-story building was investigated as a case study and the effects of X-braces elimination in its lower stories studied. In addition, the possibility of replacement of the X-braces in soft-stories with equivalent moment resisting frame inspected in two different phases. In first phase, the stiffness of X-braces and equivalent moment-resisting frames evaluated using classic equations. In final phase, diagonals removed from the lowest story to develop a soft-story and replaced with moment resisting frames. Then, the seismic stiffness variation of moment-resisting frame evaluated using nonlinear static and dynamic analyses. The results show that substitution of braced frames with an equivalent moment-resisting frame of the same stiffness increases story drift and reduces energy absorption capacity. However, it is enough to consider the needs of building codes, even using equivalent moment resisting frame instead of X-Braces, to avoid soft-story stiffness irregularity in seismic design of buildings. Besides, soft-story development in the second story may be more critical under strong ground excitations, because of interaction of adjacent stories.

Numerical Investigation of the Behavior of MERO Joint System Under Combined Loading Regarding Helical Threads of Elements

Mehdi Ebadi Jamkhaneh,Amir Homaioon Ebrahimi,Maedeh Shokri Amiri 한국강구조학회 2020 International Journal of Steel Structures Vol.20 No.3

A comprehensive fi nite element (FE) model of bolt-ball joint, as called MERO joint, is presented in this paper for a double layer grid structure. In double layer grids, the main internal forces are axial forces. The defl ection and rotation patterns of the connector are studied under diff erent loading conditions using the ABAQUS FE software. The applied forces on the connector are determined using displacement control. In order to take into account the connector eff ects in structural analysis, their behavior under combined loading should be predicted. To determine the load–displacement relationship of the MERO connection, numerical models were carried out on a connector of this type using of 3D FE method. The obtained load–displacement and moment- rotation relationships were used under diff erent loads. The results of the FE simulation with experimental results have a good match. Compressive axial load increases the fl exural stiff ness of the connection and decreases the elastic bending moment. Furthermore, the equivalent stiff ness of bolt with the whole of complexities was proposed.

Guided Local Buckling (GLB) Theory for Short Braces

Parviz Ebadi,Saeid Sabouri-Ghomi 한국강구조학회 2012 International Journal of Steel Structures Vol.12 No.2

According to recent earthquake experiences and experimental results, the local buckling is the most important parameter for limiting the ductility of short braces and prevents earthquake energy absorption in larger drifts. A new theory is introduced to prevent harmful effects of local buckling and use it as an energy absorption device in braced frames. According to this theory oblique stiffeners are provided inside braces section and it is expected to divide lateral drift of the system to smaller deflections inside stiffeners intervals. As much as number of local buckling along braces increases, more energy will be absorbed and the fracture life of the sections increases considerably. This theory is supported by half-scale experimental results and numerical modeling. The obtained results represent uniform and stable energy absorption and reasonable system ductility.

Experimental and Numerical Investigation of Steel Moment Resisting Frame with U-Shaped Metallic Yielding Damper

Mehdi Ebadi Jamkhaneh,Amir Homaioon Ebrahimi,Maedeh Shokri Amiri 한국강구조학회 2019 International Journal of Steel Structures Vol.19 No.3

This study introduces U-shape metallic yielding damper (UMYD) as an energy dissipation system. This damper may be used as a replaceable and cost-eff ective tool and fuse in structural frames to improve lateral ductility, energy absorption and damping of structural systems under earthquakes. A series of static cyclic tests were conducted in order to examine the performance of UMYD and the response of force-displacement, lateral strength, elastic stiff ness and energy absorption were achieved. Finite element numerical studies were conducted through changing damper geometrical parameters. Mathematical model was presented to estimate elastic stiff ness of damper and was compared with numerical specimen results, which acceptable conformity. Finite elements models indicated that UMYD abilities energy absorbability in large displacements without loss of strength and stiff ness, which may be a proper complementary system for lateral load-bearing systems. The behaviour of two 4- and 8-storey steel frames with moment resisting frame system was analysed under four diff erent earthquakes under two states of with and without damper. The seismic performance of frames was analysed with respect to fl oors inter-storey drift, frame base shear and fl oors shear. The non-linear time historey analysis results demonstrated that 8-storey frame without UMYD failed to maintain the structure performance level within life-safety level, whilst under all states using damper, performance level remained within such level and a decrease in fl oors shear and inter-storey drift was observed.

Synthesis and characterization of CdS/Bi2S3 nanocomposite via simple microwave approach

Mohammad Ebadi,Somayeh Abedini,Omid Rezai,Mosleh Mohammadi Rad 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.5

CdS/Bi2S3 nanocomposite was synthesized successfully via microwave method. Different parameters such as time effect, power effect and precursor concentration effect were investigated on product size and morphology. The products were characterized with X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Also the optical properties of synthesized sample were investigated by UV–vis diffuse reflectance spectroscopy (DRS).

COD removal from gasfield produced water using photoelectrocatalysis process on coil type microreactor

Sadegh Ebadi,Karim Ghasemipanah,Ebrahim Alaie,Alimorad Rashidi,Alireza Khataee 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.98 No.-

A special type of reactor with a high active surface-to-volume ratio was used for investigation of organicpollutants degradation from a gasfield produced water by photoelectrocatalysis process. The GC–MSanalysis showed that there were more than 50 organic substances in this wastewater; therefore, COD wasconsidered as the target parameter for studying. A simple evaporation process used for decreasing highTDS of the wastewater reduced its electrical conductivity from 6300 mS/cm to 1100 mS/cm and also initialCOD decreased simultaneously from 9500 mg/L to 750 mg/L. Distilled wastewater from the evaporationprocess was treated again by the photoelectrocatalysis process using a coil type microreactor, and its CODdropped off to 143 mg/L. Instead of usual semiconductors in photoelectrocatalysis like TiO2, boron carbonnitride (BCN) nanosheets are used as a photocatalyst in this study. Investigating the impact of differentparameters on COD removal efficiency showed that the greatest COD removal efficiency (81%) wasobtained at residence time 15 min, pH = 3, applied cell voltage 20 V, electrical conductivity = 2500 mS/cmand H2O2 concentration of 8 mM.

Ultrahuge Light Intensity in the Gap Region of a Bowtie Nanoantenna Coupled to a Low-mode-volume Photonic-crystal Nanocavity

Nassibeh Ebadi,Reza Yadipour,Hamed Baghban 한국광학회 2018 Current Optics and Photonics Vol.2 No.1

This paper presents a new, efficient hybrid photonic-plasmonic structure. The proposed structure efficiently and with very high accuracy combines the resonant mode of a low-mode-volume photonic-crystal nanocavity with a bowtie nanoantenna’s plasmonic resonance. The resulting enormous enhancement of light intensity of about 1.1 × 10<SUP>7</SUP> in the gap region of the bowtie nanoantenna, due to the effective optical-resonance combination, is realized by subtle optimization of the nanocavity’s optical characteristics. This coupled structure holds great promise for many applications relying on strong confinement and enhancement of optical field in nanoscale volumes, including antennas (communication and information), optical trapping and manipulation, sensors, data storage, nonlinear optics, and lasers.

Mathematical modeling of mass transfer in multicomponent gas mixture across the synthesized composite polymeric membrane

Abtin Ebadi Amooghin,Toraj Mohammadi,Pardis Moradi Shehni,Ali Ghadimi,Mohtada Sadrzadeh 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.3

This study presents a new mathematical model to investigate the ternary gas mixture permeation across a synthesized composite PDMS/PA membrane. A novel algorithm is introduced for direct determination of diffusion coefficients. It pertains to study gas permeation through concentration dependent systems and comparing with traditional time lag method confirms the precision of this approach. Feature is that this method does not require physical properties of the membrane. Accordingly, it can be used as a general comprehensive model. In addition, molecular pair and molecular trio interactions were taken into account and in order to investigate the deviation of gas mixture from ideality, fugacities were calculated. The results showed that permeabilites of H2 and CH4 increase with increasing feed temperature and fugacity, while that of C3H8 decreases. Moreover, increasing C3H8 concentration improved permeation properties of all components. The results demonstrated that considering the concentration dependent system (CDS) leads to the small deviation of about less than 10%, while the deviation of 50–100% by the concentration independent system (CIS) was acquired. Additionally the results indicated that permeability of the lighter gases is specially affected by diffusivity, while solubility is dominant on permeability of the heavier gases.

Seismic Behavior of Steel Braced Frames Equipped with Metal Foam

Mehdi Ebadi Jamkhaneh,Mohammadreza Rezaei,Masoud Ahmadi 한국강구조학회 2021 International Journal of Steel Structures Vol.21 No.4

One of the methods for improving the seismic behavior of structures was to use inactive control devices. Recently, in civil engineering applications, a relatively new material named metal foam has been utilized progressively due to its high energy dissipation capability and remarkable axial strain. In this study, several non-linear time-history analyses were conducted for investigating the seismic behavior of steel frames equipped with the composite brace using a three-dimensional (3D) fi nite element (FE) method. Crushable foam (CF) and elastic-perfectly plastic models were considered for metal foam and steel members. FE results revealed that the maximum drift ratio decreased by 35% and 72% under near-fi eld and far-fi eld records in the steel frames equipped with composite brace compared to the conventional steel brace frames. Employing the composite brace led to prevent global buckling of the brace and consequently decrease in load-bearing capacity. Furthermore, composite brace caused the reduction of bending moment demand in the fi rst-story column by 18%.