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- 저자 : 홍효선 ( Hyo Sun Hong ) (검색결과 1 건)
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Total antioxidant status (TAS) 참고치 및 고콜레스테롤혈증, 당뇨병과의 관련성에 관한 연구
권영일 ( Young Il Kwon ),서은주 ( Eun Ju Seo ),홍효선 ( Hyo Sun Hong ),안희은 ( Hee Eun Ahn ),박찬호 ( Chan Ho Park ),노명희 ( Myung Hee Rho ) 대한임상검사과학회 1999 대한임상검사과학회지(KJCLS) Vol.31 No.2
Introduction : The Object of this study is to investigate the reference ranges of total antioxidant status(TAS) according to age and sex in korea. The human body is constantly under attack from free radicals. Free radica1s are highly reactive molecules and once formed, attack cell structures with the body. As a resu1t, free radicals have been implicated in numerous disease. In hea1thy individua1s, the antioxidant system defends tissues against free radica1 attack. Methods and materials : We measured the tota1 antioxidant status of 90 norma1 group, 30 diabetes group and 30 hypercholesterolemia group. (The each group sex ratio : ha1f to ha1ij For each test, age and sex related variations were assessed and reference values were estimated for three different age groups.(below 20, 21-40, above 41) TAS measured by Randox Tota1 Antioxidant reagent and Hitachi 7150. Results : ’fhe reference va1ues according to age were 0.930- 1.332mmolfL in below 20 years of age, 1.007 -1.391mmolfL in 21-40 years of age and 0.995- 1.295mmolfL inabove 41 year of age and showed statistica11y significant difference.(P<0.05) The Reference ranges of tota1 age group, ma1e and fema1e group were 0.991- 1.343mmolfL, 1.038- 1.370mmolfL, and 0.977 -1.285mmolfL respectively. Between the ma1e and fema1e group were statistically signficant difference.(P<0.05) The TAS means of diabetes and hypercholesterolemia were 1.26mmoljL and 1.23mmoljL respectively. TAS values of hypercholerterolemia an normal group were no significant difference whereas diabetes and normal group were significant difference.(P<O.OOl) Conclusions : We established that reference ranges were analyzed age and sex related variations for total antioxidant status. Between experimental groups showed generally significant differences. In the future, correct diagnosis of disease induced free radicals need to measure total antioxidant level and each antioxidants.
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