http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
피록시캄의 피부투과 및 소염효력에 대한 알코올성 하이드로겔 시스템의 영향
기민효(Min Hyo Ki),신희종(Hee Jong Shin),이강우(Kang Woo Lee),김재욱(Jae Wook Kim),김정우(Jung Woo Kim),홍청일(Chung Il Hong) 한국약제학회 1999 Journal of Pharmaceutical Investigation Vol.29 No.3
These studies were designed to determine the effect of hydroalcoholic gel system (lower alkanol concentration : 40-60%) compared to general hydrogel system (lower alkanol concentration : 10-35%) on transdermal delivery of piroxicam and its anti-inflammatory activity. Piroxicam was incorporated into a hydroalcoholic gel and a hydrogel containing polymers, solvents, and cosolvents. The pH of gel was about 6.3-7.3 and the solvent mixtures were composed of water and various concentrations of ethanol (35, 40, 50, and 60%). For the in vitro study, the skin permeation of piroxicam from the gel formulations was investigated using Franz modified diffusion cells fitted with hairless mouse skin. For the in vivo study, the anti-inflammatory activity of hydroalcoholic gel was compared to other commercial products (piroxicam hydrogel and ketoprofen hydrogel) in rat and human. The anti-inflammatory activity was determined using carrageenan-induced foot edema model in rat. For the clinical study, it was evaluated from determining efficacy and acceptability with 98 patients suffering from musculoskeletal pain. A novel piroxicam hydroalcoholic gel was successfully formulated in the range of 40-50% of ethanol as solvent, more than 10% of propylene glycol, 5% of Transcutol^ⓡ and 1% of benzyl alcohol. The skin permeation of piroxicam using hydroalcoholic gel system was greater than that of general hydrogel system (flux : 139.1-148.2 ㎍/㎠/hr vs. 43.0-84.5 ㎍/㎠/hr) in vitro. In carrageenan-induced edema model, the anti-inflammatory activity of hydroalcoholic gel was better than that of piroxicam hydrogel for edema inhibition (75.1% vs. 62.9%, p<0.01). In clinical study, each visual analogue of pain scale (improvement point: 15.57 point vs. 3.61 point, p<0.05) and global acceptability assessment (satisfied patients: 76.2% vs. 47.7%, p<0.05) of new hydroalcoholic gel was significantly increased compared to ketoprofen hydrogel. The inclusion of piroxicam to the hydroalcoholic gel system was found to improve significantly the skin permeation in vitro and the anti-inflammatory activity in vivo.
신규 캄토테신계 항암제 CKD-602의 약물동태 : 분포, 대사 및 배설
이주몽(Ju Mong Lee),이준희(Jun Hee Lee),김준겸(Joon Kyum Kim),신희종(Hee Jong Shin),이형기(Hyung Ki Lee),이상준(Sang Joon Lee),홍청일(Chung Il Hong) 大韓藥學會 1998 약학회지 Vol.42 No.4
The distribution, metabolism and excretion of CKD-602{20(S)-7-[2-(N-Isopropylamino)ethyl]camptothecin HCI), a new camptothecin derivative, were investigated in rats after a single administration of CKD-602. 1. The tissue levels of CKD-602 given to mice by the intravenous route at a dose of 20mg/kg were the highest in intestine, followed in descending order by kidney, liver, stomach,lung, heart, spleen and plasma. The concentrations of CKD-602 after 24hrs decreased to less than 2% of the peak level in most tissues except the skin. The urinary and fecal excretion of CKD-602 were 47.6% and 44.4% of the administered dose, respectively, with 0.7% remaining in the rinse. 2. After administration of CKD-602 at 10mg/kg in rats, metabolism of this compound was examined in plasma, urine, and feces. The plasma samples were collected for 24hr, urinary and fecal samples for 72hr. While any peak of CKD-602 in HPLC chromatograms was not detected from plasma and urine it was detected in feces (peaks, 9.8 min). However, additional peak area was about 0.5% of the peak area of parent CKD-602. Therefore, CKD-602 may be eliminated with the parent form and rarely metabolized in the body. 4. After I.v. administration of CKD-602 at 10mg/kg in rats, urinary and fecal excretions were examined for 72hrs post dose period. 87% of total urinary excretion of CKD-602 was excreted within 8hr after administration, 53%, and 32% of total fecal excreted amounts were determined in 0-24 hr and 24-48hr periods, respectively. The total excretion amounts of CKD-602 into urine and feces were 94% of the administered dose.