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      • 고양이의 실험적 국소뇌허혈시 Naloxone이 뇌조직 사립체의 Cytochrome Oxidase Activity 및 Lipid Peroxidation에 미치는 영향

        최창명,김관태 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.1

        The effect of naloxone on anesthetizcd cats with focal cerebral ischemia, induced by middle cerebral artery(MCA) clipping through the transorbital approach, were studied. In five cats of sham control group, physiologic saline was infused intravenously after left eyeball enucleation. Five other cats, in which physiologic saline was infused after left MCA occlusion, served as control group. Also, naloxone was administered intravenously to another six cats. Twenty minutes later, a bolus intravenous injection of 10㎎/㎏ of naloxone was done. This was followed by a 2㎎/㎏/hr 3 hour continuos intravenous infusion. A neurologic examintion was performed just before decapitation and the head was stored in a deep freezer immediately at ―70℃. Brain Parenchyme was sampled in each “central core area”of MCA territory. Cytochrome oxidase activities and lipid peroxidation were measured by the Hess% Pope method and the E.D. Willis method respectively. The result were variable and the physiologic condition was also unstable. This was ascrbed to the irregularity of respiration and BP. Some cats showed stable vital signs and gas analysis. We supposed that the increase of cytochrome oxidase activity and the decrease of lipid peroxidation in the stable group were caused by the naloxone effect. If a ventilator and physiography were used to maintain stable vital sgins, and timing and dosage of naloxone administration were considered, statistically more valuable data could be obtained. Also, further evaluation and study about other drugs such as MP, mannitol, indomethacin, Ca^2+ antagonists and K-opiate receptor agonists are needed.

      • SCOPUSSCIEKCI등재

        척추경막외 말초성 T-세포 임파종의 치험 1례 : 증례 보고 Case Report

        최창명,김성호,송시헌,김윤 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.3

        A case of peripheral T-cell lymphoma, large cell type(NIH) is reported. The literature review yielded a rare case report of a malignant lymphoma especially in the even more rare epidural site. The patient's symptoms were relieved by decompressive laminectomy and subtotal removal of mass and combined scheduled chemotherapy with radiotherapy. The pathological examination revealed malignant lymphoma, diffuse, large cell type(NIH) by H & E and immunologic marker analysis.

      • SCOPUSSCIEKCI등재

        고립성 제4뇌실 수두증의 치험 1례 : 증례보고 A Case Report

        최창명,김성호,송시현,김윤 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.2

        Mental deterioration and signs of cerebellar dysfunction developed 5 years after lateral ventricle shunting in 36-year-old hydrocephalic female patient. Fourth ventricle enlargement was seen on CT scan. Reevaluation of the cerebrospinal fluid parthways with metrizamide ventriculography showed isolated fourth ventricle with aqueductal stenosis. Shunting of the fourth ventricle with an Y-connector returned the patient to normal neurological status.

      • SCOPUSSCIEKCI등재
      • SCOPUSSCIEKCI등재
      • SCOPUSSCIEKCI등재

        뇌실내출혈의 치료에서 뇌실외배액술의 임상적 분석

        최창명,송시헌,김윤 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.1

        A series of 54 adult patients with intraventricular hemorrhage (IVH) diagnosed by computed tomography (CT) scan and treated with external ventricular drainage were reviewed. In cases who occurred poor drainage of bloody cerebrospinal fluid obstruction, irrigation with urokinase solution(6,000 U/㎖) was tried. Hypertension and ruptured aneurysms accounted for 65% of the cases. Although most cases showed poor prognosis, we experienced dramatic improvements in four comatous patients who had fixed dialated pupils after spontaneous intraventricular hemorrhage with secondary acute hydrocephalus. We believe ventriculostomy to be effective in managing IVH especially in the early stage before cerebral herniation occurs. This procedure, accomplished by a convenient and relatively simple technique, led to evacuration of intraventricular blood, or the temporary or permanent cessation of progression of the hydrocephalic process, decrease in ventricular size, and normalization of ICP. However, a relatively high incidence of infection was problematic.

      • KCI등재

        윤리경영의 운영과 리더에 대한 신뢰가 조직몰입에 미치는 영향

        최창명 ( Chang Myeung Choi ) 아시아.유럽미래학회 2005 유라시아연구 Vol.2 No.2

        본 연구는 기업의 구성원을 대상으로 윤리경영의 운영과 리더에 대한 신뢰가 조직몰입에 어떠한 영향을 미치는지를 밝히고자 한 연구이다. 본 연구의 기본 모형은 윤리경영의 운영을 독립변수,조직몰입을 종속변수로 하며,이 두 변수관계에 대해 리더에 대한 신뢰가 조절효과의 역할을 할 것이라는 모형으로 설정한다. 본 연구를 위한 모집단은 윤리경영을 실시하고 있는 기업 5개사, 윤리경영을 실시하지 않는 기업 3개사를 중심으로 연구를 실시하였다. 8개 기업을 대상으로 1,000부의 설문지를 배포하여 회수된 335부중에서 불성실하게 작성된 12부를 제외한 323부를 대상으로 실증분석을 실시하였다. 실증분석의 결과는 구체적으로 다음과 같다. 첫째, 윤리경영의 운영이 조직몰입에 미치는 영향을 살펴보기 위해 설정한 가설 1의 경우 조직몰입에 영향을 주는 하위 요소들을 살펴보면,①CEO의 강력한 실천의지,②윤리교육.훈련 및 코치, ③ 이해관계자 동참유도이다. 둘째, 본 연구자는 리더에 대한 신뢰가 윤리경영의 운영과 조직몰입 사이에 조절효과가 있는 것으로 보고 가설 2를 설정하였다. 검증결과 리더에 대한 신뢰는 윤리경영의 운영과 조직몰입 사이에 부분적으로 조절효과가 있는 것으로 나타났다. 셋째, 본 연구에서는 리더에 대한 신뢰가 조직몰입에 중요한 영향을 미칠 수 있다는 판단아래 가설 3을 설정하였다. 검증결과 리더에 대한 신뢰의 하위요소인 계산에 기반한 신뢰,지식에 기반한 신뢰,동일시에 기반한 신뢰는 조직몰입에 유의한 영향을 미치는 것으로 나타났다(핵심 주제어: 윤리경영, 리더의 신뢰, 조직몰입). This study is the thesis to verify how operation of ethical management and trust of the leader affect the organizational commitment as the members of the company to accomplish the objectives. Therefore, as for basic model of this study, operation of ethical management becomes independent variable while organizational commitment becomes dependent variable, and any model, which trust of the leader will play the moderating role for these two variables, has been established. As for organizational commitment becomes dependent variable, this study tries to examine the relation between operation of ethical management and organizational commitment by taking any subjective evaluation to judge the qualitative aspect of the organization. Also, in case any analysis level is organizational level but not personal one, this study examines the relation between operation of ethical management and organizational commitment as demographic variables become the control variable because demographic variables can bestow very attentive impacts on the study result. Especially, this study has analyzed how operation of ethical management affects the organizational commitment as per trust of the leader. In this addition, this studyis executed that trust of the leader, namely calculus-based trust, knowledgebased trust, and identification-based trust, is regarded as moderating variable, also is regarded as directors or executives of the company to become the leader. It is noted that this study is the first trial in Korea. This study has been made for 5 companies executing ethical management and 3 companies not executing the one. Statistical analysis has been implemented by 323 questionnaires excluding 12 ones with insincerity among 1,000 questionnaires. Results of statistical analysis are as followings: Firstly, in case of Hypothesis-1 established to examine the factors affecting the organizational commitment, strong ① practical will of CEO,②ethic education/ training and coach, ③ induction of participation of the concerned parties are the significant factors affecting the organizational commitment. In the meanwhile, construction of ethical management system and evaluation/improvement of ethical management do not affect significantly the organizational commitment. This result shows that as for ethical management strong practical will of CEO is more important factor than any other factors in Korea. Namely, if CEO of the company expresses the strong will of ethical management and executes ethic education to the personnel, and induces the concerned parties for participation, it is judged that ethical management can be made in successful way. The fact that construction of ethical management and evaluation/improvement of ethical management do not affect significantly the organizational commitment shows that ethical management level in Korea is under the elementary step. Secondly, this research establishes Hypothesis-2 as trust of the leaderbestows any moderating effect between operation of ethical management and organizational commitment. This verification result shows that trust of the leader do not almost moderate between operation of ethical management and organizational commitment. ① It appears that the interaction factor of evaluation/improvement of ethical management and trust of the leader identically based on calculation shows any significant positive moderating effect between operation of ethical management and organizational commitment. ② It appears that the interaction factor of induction of participation of the concerned parties and trust of the leader identically based on identification shows any significant positive moderating effect between operation of ethical management and organizational commitment. Thirdly, this research examines Hypothesis-3 under the judgment that trust of the leader can affect significantly positive impact on organizational commitment. It is verified that calculus-based trust, knowledge-based trust, and identificationbased trust, which is the subordinate factors of trust, affect wholly significant positive impact on organizational commitment. The results clarified through this study can make the variables such as operation of ethical management and trust of the leader discovered in the studyof ethical management in future and such application can make abundantly the research for ethical management. Also this study indicates that trust of theleader of the company such as director, executive and etc. including CEO of the company attentively affects organizational commitment together with operation of ethical management. Last, the limitations of research and directions of future research are suggested.

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