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내독소를 투여한 백서의 패혈증 모델에서 glutamine 및 N-Acetylcysteine 투여가 간내 항산화에 미치는 효과
천성빈 ( Song Bin Chon ),김지수 ( Jee Soo Kim ),이창현 ( Chang Hyun Lee ),정성은 ( Sung Eun Jung ),윤여규 ( Yeo Kyu Youn ),서길준 ( Gil Joon Suh ) 대한외상학회 2004 大韓外傷學會誌 Vol.17 No.1
Background: Glutathione (GSH) has been known to be an important intracellular antioxidant. The aim of this study was to investigate the effects of the glutamine and N-acetylcysteine (NAC) on lipid peroxidation and antioxidant effect in sepsis model. Methods: All female Sprague-Dawley rats were given an intraperitoneal diethylmaleate (DEM) injection before treatment, and divided into four groups: control group (DEM only), lipopolysaccharide (LPS) treated group (DLPS), LPS with glutamine treated group (DLPG) and LPS with both glutamine and NAC treated group (DLPGC). Animals were killed at 6 and 24 hours after treatment. The histology and the counts of the infiltrative neutrophils, and the levels of malondialdehyde (MDA) and GSH in the liver were measured. Results: While the liver histology in the both DLPG and DLPGC groups showed mild neutrophil infiltration, vacuolization of hepatocytes, and the sinusoidal dilation compared to those of the DLPS group, there was no significant change of the neutrophil counts between the treatment groups. Both the DLPG and DLPGC groups showed decreases in liver MDA level compared to the DLPS group. Although both the DLPG and DLPGC groups demonstrated significant increases in the liver GSH level compared to the DLPS group, there was no significant change between the DLPG and DLPGC groups. Conclusion: This study showed that the administration of the glutamine and NAC in sepsis model revealed an inhibition of the lipid peroxidation and an antioxidant effect through the increase of GSH in the liver.
슈퍼와파린(superwarfarin) 살서제 중독으로 인한 장기간 혈액응고장애 1례
박찬우 ( Chan Woo Park ),조준휘 ( Jun Hwi Cho ),배준호 ( Joon Ho Bae ),문중범 ( Joong Bum Moon ),천성빈 ( Sung Bin Chon ),안기옥 ( Ki Ohk Ahn ),이희영 ( Hui Young Lee ) 대한임상독성학회 2011 대한임상독성학회지 Vol.9 No.2
Superwarfarin, such as brodifacoum, is a highly lethal vitamin K antagonist used as a rodenticide. Brodifacoum has a particularly long half-life in the body, which ranges to several months, and therefore requires prolonged treatment with antidotal vitamin K. We experienced a case whereby an 18-year-old male was presented to the hospital with a severe bleeding disorder. It was discovered that he had ingested brodifacoum rodenticide with intent to commit suicide. Despite continual treatment with vitamin K, the bleeding disorder persisted for several months before he recovered. We report this case with literature review.
대유행 인플루엔자(H1N1 2009) 급성호흡곤란증후군에 대한 체외막 산소화 장치의 조기적용 1예
이경학,이길수,오원섭,유숙원,천성빈,이승준 대한감염학회 2010 감염과 화학요법 Vol.42 No.2
Despite advanced technologies in intensive care, pandemic influenza (H1N1 2009) can rapidly progress to acute respiratory distress syndrome (ARDS) and cause death in a small subset of patients. Extracorporeal membrane oxygenation (ECMO) is expected to provide adequate gas exchange, to reduce ventilator-induced lung injury and, eventually, to improve outcome in these patients. A previously healthy, young female received mechanically ventilatory support because of rapidly progressive respiratory failure caused by 2009 H1N1 influenza. As she failed to respond to high ventilatory support, ECMO was instituted at 6 hours after admission. We describe detailed course of case and literature review on ECMO, helping physicians make a decision to initiate ECMO in patients with influenza-related ARDS.