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주건 ( Kon Chu ),신동인 ( Dong In Sin ),노재규 ( Jae Kyu Roh ) 한국조직공학과 재생의학회 2005 조직공학과 재생의학 Vol.2 No.4
Neural stem cells (NSCs) are the most primordial and least committed cells of the nervous system, the cells that exist before regional/functional specification develops. NSCs have the following functional properties: (1) multipotency, (2) the ability to populate a developing region and/or repopulate an ablated or degenerated region of the nervous system with appropriate cell types, (3) the ability to be serially transplanted, and (4) Self-renewal. Recent experiments have shown that NSCs can be transplanted in many neurological disorder models (ischemia, hemorrhage, epilepsy, Parkinsonism, brain tumor, Huntington`s disease, multiple sclerosis, peripheral neuropathy, spinal cord injury, and motor neuron diseases) and can ameliorate the pathogenic insult. This review focuses on the transplantation efficacy in stroke, and optimization strategy for achieving better outcome, considering the pathogenesis of specific diseases.