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- 저자 : 조창숙 ( Chang Suk Jo ) (검색결과 2 건)
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제1형 당뇨모델 흰 쥐의 간과 신장에 미치는 한약재 첨가 콩 발효식품의 영향
조창숙 ( Chang Suk Jo ),김소영 ( So Young Kim ),최문열 ( Moon-yeol Choi ),김미형 ( Mi Hyeong Kim ),김미려 ( Mi Ryeo Kim ),서부일 ( Bu-il Seo ) 한약응용학회 2021 한약응용학회지 Vol.21 No.1
Objective : Diabetes mellitus (DM) is a chronic metabolic disorder characterized by high blood glucose levels due to the relative or absolute deficiency of insulin action, and has become a major public health and economic problem worldwide. Godjang (GJ) was made by fermentation of soybean with herbal medicine. The purpose of this study was to investigate the effects of Godjang (GJ) water extracts on antidiabetic markers in streptozotocin (STZ, 65 mg/kg of BW, IP injection)-induced type 1 diabetic rats. Methods : Experimental DM was induced by intraperitoneal injection with a single dose of STZ (65 ㎎/㎏) in Sprague Dawley rats. In other words, animals were divided into 4 groups; NG (normal group + 0.9% saline), COS (diabetic group + 0.9% saline), GJ 200 (diabetic group + Godjang (200 mg/ kg, BW)), GJ 600 (diabetic group + Godjang (600 ㎎/㎏, BW)). Treatments were performed orally administration for 4 weeks. After the experiment of 4 weeks, the blood samples and organs were collected and then serum levels of glucose, BUN, creatinine, TC, TG, ATS and ALT were measured, respectively. Results : At the 4 weeks of GJ administration, the body weight gain were lower in diabetic groups than normal group. The serum glucose levels were significantly lower in the GJ 200 and 600 group than COS group. In serum, AST and TG levels significantly decreased in GJ 600 group compared to COS group. The serum levels of ALT, TC, BUN and creatinine were decreased in GJ 200 and 600 groups compared to COS group. Conclusion : Our results suggest that Godjang water extracts would have antidiabetic effects in STZ-induced diabetic rats.
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한약재 함유 대두발효 추출물이 streptozotocin으로 유발된 당뇨 흰쥐의 혈당 및 조직형태학적 변화에 미치는 영향
조창숙 ( Chang Suk Jo ),김소영 ( So Young Kim ),최문열 ( Moon-yeol Choi ),김미형 ( Mi Hyung Kim ),김미려 ( Mi Ryeo Kim ),서부일 ( Bu-il Seo ) 대한본초학회 2022 大韓本草學會誌 Vol.37 No.1
Objective : This study was designed to investigate anti-diabetic effects of fermented soy bean extract with herbal medicines (Godjang) in diabetic rat models induced by streptozotocin (STZ) injection. Method : Changes in body weight, drinking water, and food intake were observed for 4 weeks before and after induction of diabetes mellitus in rats. The anti-diabetic capacity of Godjang was analyzed by fasting blood glucose (FBG) every week. Also, after 4 weeks of administration, the oral glucose tolerance test (OGTT) was performed, and then blood levels of insulin were checked. And serum levels of total cholesterol and triglycerides were determined. Histomorphological changes of liver, kidney and pancreatic tissues were also observed in STZ-induced diabetic rats and Godjang administered rats. Result : In Godjang administered group, body weight and water intake were more lower than that of STZ-induced diabetic rats. FBG was decreased in the Godjang administered group than STZ-induced diabetic group. According to OGTT, blood glucose levels at 30 minutes and 60 minutes significantly decreased in Godjang administered group than in STZ-induced diabetic control group. Administration of Godjang extract for 4W significantly decreased levels of serum glucose, total cholesterol (TC), triglycerides (TG) in diabetic rats. In histomorphological analysis of kidney, liver, Godjang administrated groups showed the inhibition of pathological damage. Conclusion : These results suggest that Godjang extract has an anti-diabetic action through decrease in serum glucose, TC, TG levels and recovery of the morphological changes in kidney and liver in STZ-induced diabetic rats.1)
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