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황금 (Scutellariae Radix) 에탄올 추출물의 Hyaluronic Acid 합성 효과에 대한 연구
정영수 ( Yeong Su Chung ),하헌용 ( Hun Yong Ha ) 대한미용학회(구 대한미용과학회) 2015 대한미용학회지 Vol.11 No.4
Scutellariae Radix is an herbal medicine used for the treatment of febrile and dermatological diseases in oriental medicine. Hyaluronic acid (HA) is a mucopolysaccharide occurring naturally in living organisms. It is a highly hydro- philic molecule known to be associated with skin hydration and skin aging. Given the utility of Scutellariae Radix for treating dermatological diseases and febrile diseases that may cause skin dryness in humans, we investigated its effect on HA synthesis. To determine cytotoxicity, hyaluronic acid synthase 2 (HAS2) gene expression and hyaluronic acid production in HaCaT cells, MTT assay, RT-PCR and ELISA were used. HAS2 gene expression increased at all treatment concentrations of Scutellariae Radix extract. Hyaluronic acid production was higher at all concentrations of Scutellariae Radix extract than the control group. Therefore, we suggest that Scutellariae Radix can make play a role in regulating HA synthesis and may have a moisturizing effect on human skin.