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Methotrexate 의 D 및 L 체가 사람 임파구 염색체에 미치는 영향에 대하여
김정중(Jeongjoong Kim),고건일(Geonil Ko),정연태(Yoentae Jeong),김재백(Jaebaek Kim) 한국약제학회 1986 Journal of Pharmaceutical Investigation Vol.16 No.4
Sister chromatid exchanges (SCEs) induced by D-methotrexate (MTX) was investigated and compared to L-methotrexate at same doses in cultured PHA activated human lymphocytes. The results is as follows; the frequencies were found to be 11.00±0.31, 13.99±0.27, 16.97±0.32, 21.00±0.43, and 7.85±0.26 in treated with 10^(-6), 10^(-6) Mol D-MTX. L-MTX and the control, respectively. L-MTX was found to be more potent for inducing SCE than D-MTX. The regions generally vulnerable to D -and L-MTX were 1p32 and 1p23 in chromosome 1, 2q21 and 2q31 in chromosome 2, 3q21 and 3p21 in chromosome 3. SCE induced by both D-and L-MTX occurred mostly in the G-light band regions.