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괄루근으로부터 추출한 다당류의 항당뇨활성 및 당뇨성 쥐의 글루타치온대사에 미치는 영향
정연봉(Yeoun Bong Chung),이종철(Chong Chul Lee) 대한약학회 1995 약학회지 Vol.39 No.5
This investigation was aimed at the study of the antidiabetic activity and effect on hepatic glutathione metabolism of polysaccharide from Trichosanthes kirilowii in hyperglycemic rats with alloxan (175mg/Kg, i.p.). As the results, the polysaccharide inhibited the increase of blood glucose, triglyceride level and lactate dehydrogenase activity, but cholesterol did not change. And it increased protein bound-SH, nonprotein bound-SH, glutathione level and inhibited the decrease of glutathione S-transferase.
서보권(Bo Gwon Seo),정연봉(Yeoun Bong Chung),김용규(Yong Kyu Kim),신옥진(Ok Jin Shin),이종철(Chong Chul Lee) 대한약학회 1993 약학회지 Vol.37 No.3
It is well known that lipidperoxide, formed in vivo, induced the denaturation of enzyme and destruction of cell membrane to acute injury of tissue. Aralia elata have physiological activates, the improvement of lipid metabolism, antidiabetic activity etc., which was thought to have the relationship to lipid peroxidation. The anti-lipidperoxidative effect of Aralia elata have not yet established. In this study, we examined the anti-lipidperoxidative effects of Aralia elata (Butanol fraction) on CCl4 induced lipidperoxidation in rats, and elucidated the anti-lipidperoxidative mechanism. In rat liver homogenate intoxicated with CC14 (0.5ml/100g), BuOH fraction of Aralia elata (80mg/Kg/day) exhibited 85.41% anti-lipidperoxidative effect but in serum 69.63% inhibitory effects, respectively. In mitochondrial and microsomal fraction showed inhibition of 55.85% and 69.30%, respectively. In order to elucidate the mechanism of anti-lipidperoxidation effects of Aralia elata, enzymatic (NADPH dependent) and non-enzymatic (Ascorbic acid catalyzed) reaction, in vitro, were performed. In enzymatic reation, Aralia elata exhibited 59.43% anti-lipidperoxidation effects, but in non-enzymatic reaction exhibited 43.27% inhibition. Therefore, it is noteworthy that antioxidative power of them may mainly results from the inhibition by enzymatic reaction.
일엽초(Lepisorus thunbergianus)의 부탕올 추출물이 생체 지질 과산화에 미치는 영향
정연봉,안문규,이종철 慶星大學校 1993 論文集 Vol.14 No.4
In this study, we examined the anti-lipid peroxidative effects of lepisorus thunbergianus on CCl₄ induced lipid peroxidation in rats, and elucidated the anti-lipid peroxidative mechanism. In rat liver homogenate intoxicated with CCl₄(0.5ml/100g), BuOH fraction of Lepisorus thunbergianus (100mg/Kg/day) exhibited 84.90% anti-lipid peroxidative effect but in serum 79.63% inhibitory effects, respectively. In mitochondrial and microsomal fraction showed inhibition of 55.32% and 61.05%, respectively. In order to elucidate the mechanism of anti-lipid peroxidation effects of Lepisorus thunbergianus, enzymatic(NADPH dependent) and non-enzymatic(Ascorbic acid catalyzed) reaction, in vitro, were performed. In enzymatic reaction, Lepisorus thunbergianus exhibited 60.64% anti-lipid peroxidation effects, but in non-enzymatic reaction exhibited 47.92% inhibition. Therefore, it is noteworthy that antioxidative power of them may mainly results from the inhibition by enzymatic reaction.
일차배양 간세포를 이용한 Nitric Oxide(NO)의 항산화 활성 및 약물대사 효소에 미치는 영향
남성윤,정연봉,김동석,이종철 慶星大學校 1996 論文集 Vol.17 No.2
The purpose of the present study was to determine the antioxidative activity and effects on drug metabolism of nitric oxide. In experiments, the incubation of isolated rat hepatocytes with lipopolysaccharide(LPS) resulted in the slight inhibition of lipid peroxidation but superoxide productivity not affected. Also LPS increased intracellular glutathione and glutathione S-transferase activity. In contrast, N??-monomethyl-L-Arginine (L-NMA), an inhibitor of both the constitutive and inducible nitrix oxide synthases, decreased in lactate dehydrogenase. And, LPS inhibited increasse of ethoxycoumarin O-deethylase activity by phenobarbital, but other monooxygenase activity not affect. Treatment of L-NMA to phenobarbital -pretrteated rat hepatocytes results in slight increase of cytochrome P-450 I Al specific enzyme ethoxyresorufin O-deethylase activity.
이종철,남성윤,정연봉 慶星大學校 1995 論文集 Vol.16 No.2
In this research, we examined the effect of Prunus mume and Loranthi ramulus on the active oxygen in CCI₄induced rats. In rat liver homogenate intoxicated with CCI₄(0.5ml/100g),BuOH fraction of Prunus mume and Loranthi ramulus showed a remarkable inhibition of the lipid peroxidation. And Prunus mume reduced the superoxide productivity by CCI₄about 30%, but the inhibition by Loranthi ramulus was small in contrast with Prunus mume. In the group of Prunus mume treatment, the contents of protein bound-SH, and glutathion and the activity of glutathion S-transferase was recovered to the normal level but the effect of the Loranthi ramulus was small in contrast with Prunus mume.
Adriamycin의 독성 발현에 미치는 백렴(Ampelopsis radix)의 영향
김동석,이성호,정연봉 한국식품영양학회 1994 韓國食品營養學會誌 Vol.7 No.3
Adriamycin의 독성 및 이의 경감을 위한 백렴의 항산화 활성을 검토한 결과 in vivo에서 adriamycin에 의한 독성발현의 1차적 반응은 지질 과산화에 의한 것이 아닌 다른 경로에 의한 것으로 생각된다. 또한 시료로 사용된 백렴의 체내 지질 과산화 억제에 대한 작용은 뚜렷하지 않았으며, in vivo에서의 thiol기 현저한 증가를 보이는 것으로 보아 시료의 항산화 활성은 체내 glutathione 및 이와 관련한 효소의 활성화의 관련이 있을 것으로 생각된다. Adriamycin is a major cancer chemotherapeutic agent against a wide range of human neoplasms. However, its clinical application is limited since it has a variety of side effects, bone marrow suppression and car diotoxity, and this toxicity appears by free radical. This study investigated the effect of Ampelopsis radix on the toxicity of adriamycin. The methanol fraction reduced slightly adriamycin induced lipid peroxidation and superoxide production at the dose of 50㎎/㎏. i.p., respectively. During the adriamycin administration. protein bound-SH, nonprotein bound-SH, and glutathione-S-transferase did not change, but methanol fraction treated group were markedly increase. These results indicated that Ampelopsis radix has a major influence on the thiol group and related enzyme activity on the antioxidative effects.
드릅나무(Aralia elata) 부탄올 추출물의 항암 및 면역 활성에 미치는 영향
김용규,남성윤,정연봉,이종철 慶星大學校 1994 論文集 Vol.15 No.2
The butanol fraction from the bark of Aralia elata SEEM(Araliaceae) showed marked antitumor and cytotoxic activity. The solid tumor growth inhibition ratio of the BuOH fraction againse sarcoma-180 was at highest level of 74.15% while administrating in the concentration of 100mg/Kg/day and life prolongation ratio showed 52.75% in the concentration of 100mg/Kg/day. In incubation of sarcoma-180 tumor cell with BuOH fraction, viability was 15.73%, the direct cytotoxic activity of Aralia elata was remarked in vitro. But the administered group being compared with the controlled group, no significant changes revealed in the immune reaction.