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과산화수소 , 무수피로인산나트륨 및 불화나트륨을 배합한 특수세치제의 치아미백효과에 관한 실용실험연구
정세환,배광학,이원재,문혁수,백대일,김종배 대한구강보건학회 2001 大韓口腔保健學會誌 Vol.25 No.2
The purpose of this study was to evaluate the effects of therapeutic toothpaste containing tetrasodium pyrophosphate, vitamin-E and hydrogen peroxide on the whitening. 55 adult male and female subjects aged 20 to 29 year-olds completed 2-week, double-blind clinical study. Subjects were divided by two balanced groups according to baseline tooth brightness. Trubyte Bioform shade guide was used to score the tooth brightness. There was statistical significance of the brightness changes between the therapeutic toothpaste and the control toothpaste after 2 weeks(P<0.05). This result suggest that therapeutic toothpaste containing tetrasodium pyrophosphate, vitamin-E, and hydrogen peroxide be effective on improving tooth whitening.
Triclosan 과 Pyrophosphate 및 Tranexamic acid 를 배합한 세치제의 치주질환원인균과 구취유발원인균에 대한 항균효과에 관한 연구
김종배,문혁수,백대일,윤정원,정세환,신미정,이기현 대한구강보건학회 1998 大韓口腔保健學會誌 Vol.22 No.3
The antimicrobial effects of dentifrice containing triclosan, pyrophosphate and tranexamic acid against the pathogens of periodontal disease and halitosis such as Streptococcus sanguis, Actinomyces viscosus, Candida albicans, Actinobacillus actinomycetemcomitans, Capnocytophaga ochracea, Fusobacterium nucleatum, Prevotela intermedius, Phopyromonas gingivalis were evaluated with the agar dilution and paper disc methods. The results obtained were as follows: 1. Both the experimental dentifrice containing triclosan, pyrophosphate and tranexamic acid and the control dentifrice showed the antimicrobial activities on all the microorganisms tested. 2. The experimental dentifrice containing triclosan, pyrophosphate and tranexamic acid showed more effective antimicrobial activities on Actinobacillus actinomycetemcomitans, Capnocytophaga ochracea, Phopyromonas gingivalis, relative to the control dentifrice.
Triclosan 을 배합한 세치제의 치은염완화효과와 치면세균막형성억제효과 및 구강질환원인균에 대한 항균효과에 관한 연구
김종배,문혁수,백대일,마득상,윤정원,박덕영,정세환,신미정,서우석 대한구강보건학회 1998 大韓口腔保健學會誌 Vol.22 No.2
A total of 62 adult male and female subjects began a 6-week, double-blind clinical study comparing the effect on gingivitis and plaque formation of a 0.2% triclosan-containing dentifrice to a placebo dentifrice. Placebo dentifrice had the same formulation with experimental dentifrice except it did not contain 0.2% triclosan. Subjects were divided by two balanced groups according to baseline plaque and gingivitis scores. Then, they were assigned to use either the the triclosan-containing dentifrice or the placebo dentifrice for the next 6weeks. Finally, 28 experimental and 24 control subjects completed 6 weeks of the study. Plaque index and gingival index were scored 3 times : before the study, after 4weeks of use of each dentifrice, after 8weeks of use of each dentifrice. Quigley-Hein Plaque index and Loe-Silness Gingival index were used to score each index. Also, the antimicrobial effects of a 0.2% triclosan-containing dentifrice against the pathogens of oral diseases such as Streptococcus mutans, Streptococcus sanguis, Lactobacillus acidophilus, Actinomyces viscosus, Fusobacterium nucleatum were evaluated with the agar dilution and paper disc methods. The results obtained were as follows: 1. After 6 weeks, the triclosan-containing dentifrice was shown to provide a 20.4% reduction in gingivitis, as compared to the placebo dentifrice, but not statistically significant(P>0.05). 2. After 6 weeks, the triclosan-containing dentifrice was shown to provide a statistically significant reduction in plaque formation, as compared to the placebo dentifrice(P<0.05). 3. The triclosan-containing dentifrice showed more effective antimicrobial activities on Lactobacillus acidophilus, Actinomyces viscosus, as compared to the placebo dentifrice.
불화나트륨과 자일리톨배합양치액의 법랑질표면미세경도변화와 구취감소효과에 관한 연구
김종배,문혁수,백대일,정세환,배광학 대한구강보건학회 1998 大韓口腔保健學會誌 Vol.22 No.2
The microhardness changes of tooth enamel by mouthrinses was investigated in vivo using acrylic mandibular removable appliance. Three different mouthrinses which contained 1) 0.02% NaF 2) 0.05% NaF 3) 0.02% NaF + 10% Xylitol were tested. Early caries-like lesions were created using 0.1M lactic acidsodium hydroxide buffer(pH 4.0). Three enamel specimens with early caries-like lesions were mounted into the recesses of lingual surface of the appliance with sticky wax. 10 subjects wore the appliance for one hour after mouthrinsing two times per day. Each subjects wore the appliance for three separate 7-days period; 0.02% NaF mouthrinse, 0.05% NaF mouthrinse, 0.02% NaF + 10% Xylitol mouthrinse. Suface microhardness were checked by microhardness tester(Shimadzu corporation Model, HMV-2000 No. 33100410, Japan) before and after mouthrinse. In order to evaluate the effect of mouthrinses on reducing halitosis, the author had analysed the volatile sulfur compounds(VSC) in halitosis after the chewing of 0.5gm garlic powder by 10 subjects. Following mouth air sampling immediately after the chewing of garlic powder, subjects used mouthrinses and reevaluated at 5 and 10 minutes after chewing of garlic powder. The evaluation of methylmercaptan in mouth air was done by gas chromatographic technic. The percent change in methylmercaptan concentration of air samples were calculated in relation to values of mouth air sample immediately after chewing of garlic powder. The obtained results were as follows: 1. The change of surface microhardness in 0.02% NaF mouthrinse group did not showed significantly between before and after mouthrinse(P>0.05), but surface microhardness in 0.05% NaF mouthrinse group and in 0.02% NaF and 10% Xylitol mouthrinse group showed significantly between before and after mouthrinse(P<0.05). 2. The change of surface microhardness was higher in 0.05% NaF mouthrinse group and in 0.02% NaF and 10% Xylitol mouthrinse group than in 0.02%NaF mouthrinse group, but there was no significance statistically. 3. The mouthrinse containing 0.02% NaF and 10% Xylitol reduced more methylmercaptan than other experimental mouthrinses at 5 minutes after the chewing of garlic powder (P<0.05).