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황순호(Soon Ho Hwang),임형엽(Hyung Yub Yim),우성주(Seung Ju Woo),김재현(Jae Hyun Kim),김동현(Dong Hyun Kim),김신규(Sin Kyu Kim) 대한약학회 1995 약학회지 Vol.39 No.1
In order to investigate the biological activity of protoberberine derivatives, they were synthesized four derivatives (1-4) of 7,8 adduct of cycloberberine, two derivatives (5, 6) treated with alkylamine or phenylamine, four compounds (7, 8) and (9, 10) adduct with 1,3-dichloroacetone and oxalychloride. Antibacterial activity of these synthesized compounds was tested.
8-Methyl-8,14-cycloberbine 유도체 합성
황순호(Soon Ho Hwang),김재현(Jae Hyun Kim),임형엽(Hyung Yub Yim),김신규(Sin Kyu Kim) 대한약학회 1994 약학회지 Vol.38 No.4
In accordance with reported references, 8-methyl-8,14-cycloberbine was derived from berberinephenolbetaine. On acidic treatment the 8-methyl-8,14-cycloberbines were converted easily to the compounds 1-7 in good yields. We developed a novel method for a Synthesis of the C8-N bond adduct compounds 8 and 9 from 8-methyl-8,14-cycloberbine by treatment with oxalyl chloride, and 1,3-dichloroaceton.