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휴대형 심전계 장치의 RR 간격의 정확도 개선을 위한 보간법 개발
이은미,홍주현,차은종,이태수,Lee, Eun-Mi,Hong, Joo-Hyun,Cha, Eun-Jong,Lee, Tae-Soo 대한의용생체공학회 2010 의공학회지 Vol.31 No.4
HRV(Heart rate variability) analysis parameter is widely used as an index to evaluate the autonomic nervous system and cardiac function. For reliable HRV analysis, we need to acquire the accurate ECG signals. Most of commercially available portable ECG devices have low sampling rate because of low power consumption and small size issues, which make it difficult to measure RR-interval accurately. This study is to improve the accuracy of RR-interval by developing R-wave interpolation technique, based on the morphological characteristics of the QRS complex. When the developed method was applied to ECG obtained at 200 Hz and the results were compared with 1000 Hz reference device, the error range decreased by 1.33 times in sitting and by 2.38 times in cycling exercise. Therefore, the proposed interpolation technique is thought to be useful to improve the accuracy of R-R interval in the portable ECG device with low sampling rate.
이은미,박동수,김도호,김현욱,조은희,안민섭,이건목,Lee, Eun-Mi,Park, Dong-Soo,Kim, Do-Ho,Kim, Hyun-Wook,Jo, Eun-Heui,Ahn, Min-Seob,Lee, Geon-Mok 대한침구의학회 2008 대한침구의학회지 Vol.25 No.3
'Needle-embedding therapy', also called 'Acupoint Embedding Therapy' is the newly induced therapy which uses specialized tools. Embedded alien substance stimulates the acupoint and helps to keep the stimulation up. Needle-embedding therapy is mainly used for chronic diseases and deficiency syndromes, and also for other diseases including acute pain and excessive syndromes. Recently, clinical doctors are studying this therapy vigorously on the foundation of 'theory of meridian pathway' and applying for facial and body esthetics such as face-lift, correction skin troubles, depilation and so on. In spite of all these effect, theories for 'Needle-embedding Therapy' doesn't seem clearly arranged yet. So we, here, present the philological basis of 'Needle-embedding Therapy' from referring to old records and newly publicated papers and consider the new trend of this therapy in Korean and China.
Florfenicol-amoxicillin 혹은 florfenicol-cefuroxime 병용투여시 어류 병원성 세균에 대한 약역학
이은미,최명진,이승진,박승춘,Lee, Eun-Mi,Choi, Myung-Jin,Lee, Seung-Jin,Park, Seung-Chun 대한수의학회 2010 大韓獸醫學會誌 Vol.50 No.4
Combination therapy of antibiotics is leading to improved efficacy or safety profiles with decrease emergence of bacterial resistance. Because of this benefit, many of antibacterial combinations have been used in veterinary practice for the past few decades. The purpose of this study was to examine the in vitro activity of an amoxicillin alone and in combination with other antibiotics against pathogenic bacteria of fish origin. Based on the fractional inhibitory concentration (FIC) index (FIC $$\leq_-$$ 0.5), a synergistic interaction was shown in combination of florfenicol with amoxicillin or cefuroxime. The combination of florfenicol and amoxillin showed higher antibacterial activity than that of florfenicol and cefuroxime. Ratio of amoxicillin and florfenicol in combination was 1 : 1, which showed the antibacterial activity against bacterial isolates of fish as compared with other ratios. A synergetic effect of the combination (amoxicillin and florfenicol) was further confirmed in the time-kill curve study. The study showed a better in vitro antibacterial activity of a 1 : 1 combination of amoxicillin and florfenicol than the individual antibacterial against bacterial isolates of fish. In conclusion, the combination of florfenicol and amoxicillin may serve as a potential antibacterial therapy in fishes infected pathogenic bacteria.
이은미,Lee, Eun-Mi 한국생명보험의학회 2007 保險醫學會誌 Vol.26 No.-
대사증후군은 비만, 이상지혈증, 고혈압, 당뇨병이나 내당능 장애가 동반되어 나타나는 증후군이다. 근래 들어 우리나라도 점차 비만 인구가 증가함에 따라 대사증후군의 유병률이 빠르게 증가하는 추세를 보여. 대사증후군에 대한 간단한 개념 정리를 하였다. 먼저 대사증후군의 정의와 진단기준을 살펴보았다. 1998년 대사증후군을 명명하고 진안기준을 제시한 WHO 진단기준, NCEP-ATP III 진단기준, 인슐린 저항성 증후군의 진단기준을 살펴보고, 기타 인종에 따른 허리 둘레 기준 및 IDF 정의를 살펴 보았다. 또한 대사증후군과 관련된 여러 인자들도 다시 확인해보고, AHA/NHLBI 진단 기준도 살펴 보았다. 우리나라는 대부분 연구에서 NCEP-ATP III 기준을 적용하고 있는데, 그 내용은 복부 비만 허리둘레 남자 102cm 이상, 여자 88cm 이상, 중성 지방 150mg/dl 이상, HDL-콜레스테롤 남자 40mg/dl 미만, 여자 50mg/dl 미만, 혈압 130/85 mmHg 이상, 공복 혈당 110mg/dl 이상이다. 복부 비만의 경우는 2000년 제정된 WHO 서태평양 지역 기준인 남자 90cm, 여자 80cm 이상으로 적용하고 있다. 다음 치료의 기본 개념을 간단히 언급 하였는데, 가장 중요한 치료는 우선적으로 생활 습관의 개선을 꼽을 수 있으며, 기타 약물요법 및 인슐린 저항성 개선제 등이 있다. 우리나라 에서도 심혈관계 질환과 당뇨병이 점차 사망 원인의 우위를 차지 하고 있으므로 대사증후군을 초기에 진단하고 관리하는 노력이 매우 필요할 것으로 생각되며, 생명보험사도 대사증후군을 하나의 증후군으로 인식하여 대사증후군의 전반적인 이해가 필요할 것으로 생각된다.
소아(小兒) 재발성삼출성(再發性渗出性) 중이염(中耳炎)에 가미형개연교탕(加味荊芥連翹湯)이 중이강삼출액내(中耳腔渗出液內) 세포활성물질(細胞活性物質)에 미치는 영향(影響)
이은미,박은정,Lee Eun-Mi,Park Eun-Jung 대한한방소아과학회 1999 대한한방소아과학회지 Vol.13 No.2
The author measured IL-2, IL-4, IL-6, TNF-${\alpha}$ and total protein(TP) level of middle ear effusion(MEE) of 24 ears - 13 ears of them had treated by antibiotics, 11 of them by Kami-hyunggyeyungyotang - of pediatric recurrent otitis media with effusion(PROME) using ELISA assay, and compared the level of cytokines(pg/ml)/TP(mg/dl). And investigated the clinical finding in those children. The results were obtained as follows: 1. The level of IL-2/TP in Kami-hyunggyeyungyotang group was significantly higher than that in antibiotics group(P〈0.05). 2. The level of IL-4/TP in Kami-hyunggyeyungyotang group was significantly higher than that in antibiotics group(P〈0.0l). 3. The level of IL-6/TP in Kami-hyunggyeyungyotang group was significantly lower than that in antibiotics group(P〈0.05). 4. The level of TNF-${\alpha}$/TP in Kami-hyunggyeyungyotang group was significantly lower than that in antibiotics group(P〈0.01) 5. 79.1% of children with recurrent otitis media with effusion(ROME) were also complicated to chronic sinusitis. The children's t-test was used to make a statistical comparison between the groups. According to above results, Kami-hyunggyeyungyotang is considered to be used for treatment 'recurrent otitis media with effusion' by control produce of cytokines which are connected with inflammatory reaction.
CRM수행기업과 NGO에 대한 인식이 기부태도와 SNS구전의도에 미치는 영향
이은미,Lee, Eun-Mi 국제문화기술진흥원 2022 The Journal of the Convergence on Culture Technolo Vol.8 No.6
With the recent paradigm shift towards 'sustainable management', corporate social responsibility is recognized as an important factor for the continuous and long-term growth of a company. This study examines how the perception of CRM performing companies and NGOs affect attitude toward donation. In addition, it was empirically investigates how the perception of donation affects the SNS word of mouth intention. In this study, a total of 180 usable responses were obtained for analysis, and SPSS and AMOS 26.0 were used to verify the validity and hypothesis of the study. As a result of the study, it was found that validity and reliability were secured. As a result of the hypothesis testing, all the hypotheses were supported, but the effect of the perception of the company implementing CRM on the donation attitude was very weakly supported. This study suggests that raising a positive awareness of CRM-performing companies and NGOs collaborating with them is an effective strategy to increase donation attitudes and SNS word-of-mouth intentions for CRM.
Vibrio fluvialis의 Oligopeptide Permease Gene 결손에 의한 생육과 Biofilm 생산의 비교
이은미,안선희,공인수,Lee, Eun Mi,Ahn, Sun Hee,Kong, In Soo 한국해양바이오학회 2006 한국해양바이오학회지 Vol.1 No.2
Vibrio fluvialis의 opp gene cluster내에 존재하는 oppABCDF 유전자를 allelic exchange 방법에 의해서 각각의 유전자가 deletion된 mutant를 제조하였다. 각각의 유전자가 deletion된 mutant의 확인은 PCR과 Southern hybridization으로 결정하였다. 각 mutant들을 BHI 배지에서 생육을 비교한 결과 배양후 4시간 이전까지는 wild strain이 모든 mutant들에 비해서 생육이 좋았으나 4시간 이후부터는 같은 수준의 생육을 보여주었다. Biofilm 생산을 비교한 결과 ${\Delta}oppA$ mutant에서 가장 높은 생산성을 보여주었다. ${\Delta}oppC,D,F$ mutant들의 biofilm 생산은 ${\Delta}oppA$ mutant 보다는 낮았으나 wild strain보다는 높은 biofilm 생산성을 보여주었다. Various ${\Delta}opp$ mutants of Vibrio fluvialis were constructed by allelic exchange method. The mutants occurred in target genes were confirmed by PCR and Southern hybridization analyses. After the exact mutants were identified, cell growth and biofilm production were examined using the respective mutants. The growth of wild strain was more rapid than mutants within 4hr incubation. Thereafter, the growth of wild strain and mutants reached to same level. When the productivities of wild strain and mutants were examined, ${\Delta}oppA$ mutant showed the highest productivity. Though ${\Delta}oppC,D$ and F mutants produced the lower production than that of ${\Delta}oppA$ mutant, the productivities of those mutants were much higher than that of wild strain.