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폐경기 여성에서 혈중 에스트라디올 농도 및 골밀도와 청력 기능과의 연관성
박은주 ( Eun Ju Park ),이동선 ( Dong Sun Lee ),김성훈 ( Sung Hoon Kim ),채희동 ( Hee Dong Chae ),김정훈 ( Chung Hoon Kim ),강병문 ( Byung Moon Kang ),전대준 ( Dae Joon Cheon ),박견 ( Kyun Park ),유항조 ( Hang Jo You ),음현진 ( Hy 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.7
N/A Objective: To clarify whether hearing sensitivity in postmenopausal women is associated with serum estradiol level or bone mineral density (BMD) Materials and Methods: From January 1999 to December 1999, serum concentration of estradiol, bone mineral densities of the lumbar vertebrae and femoral neck, and hearing sensitivity were measured in 1162 postmenopausal women. Serum concentration of estradiol was measured by radioimmunoassay. Dual energy X-ray absorptiometry (DEXA) was used to measure bone mineral densities of the lumbar vertebrae and femoral neck. Pure tone thresholds were evaluated by screening pure tone audiometry. All data were analyzed with Student`s t-test, multiple logistic regression analysis, and multiple linear regression analysis. Results: A total of 1155 patients were analyzed; 155 patients were in the hearing-loss group and 1000 patients were in the control group. On univariate analysis, significant differences were found in mean age, concentration of serum estradiol, and BMD of the fernoral neck between the two groups (mean±SD, 58.1±5.2 vs 56.0±4.3, 11.6±6.0 vs 13.1±12.0, 0.67±0.11 vs 0.70±0.11; p-value: 0.0001, 0.01, 0.02). On multiple logistic regression analysis and multiple linear regression analysis, significant association was found between age and hearing loss and between age and pure tone threshold (p-value: 0.0001, 0.0001, respectively). However, neither seum concentration of estradiol nor BMD was associated with hearing loss or pure tone threshold. Conclusion: This study suggests that hearing sensitivity in postmenopausal women is not directly associated with serum estradiol level or BMD.