http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
대한내과학회연구비 결과보고 : 죽상경화 혈관평활근세포 증식에서 세포질 칼슘 이온의 역할
유형준 ( Hyung Joon Yoo ) 대한내과학회 1999 대한내과학회 추계학술발표논문집 Vol.57 No.2
Background: To investigate the role of cytosolic Ca in the proliferation of VSMCs Methods The proliferation of aortic vascular smooth muscle cells of rats (1 % cholesterol diet fed rats and general diet fed ones), acquired by enzymatic method, was studied with MIB-1 staining, cell counting, and calcium agonists (Bay K 8644 10 M) or calcium antagonists (verapamil 10 M). Cytosolic Ca was measured by Fura 2 rnethod. Results : Masson Trichrome staining shows more disturbed cell lining, more VSMCs, more degenerated media, more collagen laydown, and more adventitial fat in the aorta of cholesterol-fed rats than in that of general diet-fed ones. There was no differences between two groups in MIB-1 staining. VSMCs of cholesterol fed-rats were more proliferated than those of general diet fed-ones. Bay K 8644 enhanced VSMCs proliferation of both groups. Verapamil blocked the incremental effects induced by Bay K 8644. In the presence of extracellular calcium ion, Bay K 8644 (10 M) stimulated the proliferation of VSMCs from cholesterol fed-rats more than that of general diet fed-ones on day 6 of culture. Preincubation with verapamil (10 M) abolished the increase in [Ca]; induced by Bay K 8644 in the presence of 1mM extracellular calcium ion. Conclusion : The enhanced proliferation of atherosclerotic VSMCs is associated with the increment in cytosolic calcium, which may be mainly due to influx of extracellular Ca.
대한내과학회연구비 결과보고 - 죽상경화 혈관평활근세포 증식에서 세포질 칼슘 이온의 역할
유형준(Hyung Joon Yoo) 대한내과학회 1999 대한내과학회지 Vol.57 No.4
Background: To investigate the role of cytosolic Ca in the proliferation of VSMCs Methods The proliferation of aortic vascular smooth muscle cells of rats (1 % cholesterol diet fed rats and general diet fed ones), acquired by enzymatic method, was studied with MIB-1 staining, cell counting, and calcium agonists (Bay K 8644 10 M) or calcium antagonists (verapamil 10 M). Cytosolic Ca was measured by Fura 2 rnethod. Results : Masson Trichrome staining shows more disturbed cell lining, more VSMCs, more degenerated media, more collagen laydown, and more adventitial fat in the aorta of cholesterol-fed rats than in that of general diet-fed ones. There was no differences between two groups in MIB-1 staining. VSMCs of cholesterol fed-rats were more proliferated than those of general diet fed-ones. Bay K 8644 enhanced VSMCs proliferation of both groups. Verapamil blocked the incremental effects induced by Bay K 8644. In the presence of extracellular calcium ion, Bay K 8644 (10 M) stimulated the proliferation of VSMCs from cholesterol fed-rats more than that of general diet fed-ones on day 6 of culture. Preincubation with verapamil (10 M) abolished the increase in [Ca]; induced by Bay K 8644 in the presence of 1mM extracellular calcium ion. Conclusion : The enhanced proliferation of atherosclerotic VSMCs is associated with the increment in cytosolic calcium, which may be mainly due to influx of extracellular Ca.