http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
증례 : 혈액종양 ; c-kit 돌연변이가 동반된 RUNX1/RUNX1T1 양성 급성골수성백혈병에서의 골수육종
윤유선 ( Yu Seon Yun ),최승화 ( Seung Hwa Choi ),유선홍 ( Sun Hong Yoo ),유진석 ( Jin Sok Yu ),이지은 ( Ji Eun Lee ),김희제 ( Hee Je Kim ),민우성 ( Woo Sung Min ) 대한내과학회 2011 대한내과학회지 Vol.81 No.4
RUNX1-RUNX1T1 양성 AML에서 c-kit 돌연변이와 골수외 백혈병의 발생은 밀접한 상관관계가 있으며 고식적 치료법에 저항성을 나타내고 궁극적으로 매우 나쁜 예후를 보인다. 그러므로 임상적으로 골수외 백혈병이 동반된 AML 환자에서 c-kit 돌연변이 여부를 확인하고 고위험군으로 분류하여 더욱 적극적인 치료를 시행해야겠다. 저자들은 최근 t (8;21) (q22;q22);RUNX1-RUNX1T1 양성 AML 환자에서 c-kit 유전자 돌연변이와 골수외 백혈병이 동반된 3예를 임상 경험하여 문헌고찰와 함께 보고하는 바이다. t (8;21)(q22;q22) is the most frequently detected cytogenetic abnormality in patients with acute myeloid leukemia (AML) and accounts for 8-21% of de novo AML. The translocation involves two genes, RUNX1 (formerly AML1) on 21q22 and RUNX1T1 (ETO) on 8q22. RUNX1/RUNX1T1 translocation confers a favorable prognosis, but a subset of patients has a precipitous course with a high incidence of relapse. This patient subset is associated with the presence of a c-kit mutation. c-kit is a proto-oncogene, which encodes a type III transmembrane tyrosine kinase, which elicits a variety of cellular responses essential for the development of bone marrow stem cells. The expression of the c-kit mutation in AML is < 2%, whereas AML with RUNX1/RUNX1T1 shows higher rates of c-kit mutation and is associated with extramedullary leukemia and poor clinical outcome. We report cases of myeloid sarcoma in patients with RUNX1/RUNX1T1-positive AML and a c-kit mutation. (Korean J Med 2011;81:517-525)
증례 : 호흡기 ; 유방 농양 및 흉막염을 동반한 폐흡충증 1예
한선영 ( Sun Young Han ),이욱현 ( Wook Hyun Lee ),유진석 ( Jin Sok Yu ),이상록 ( Sang Rok Lee ),안진영 ( Jin Young An ),고종현 ( Jong Hyun Koh ),박용근 ( Yong Geun Park ) 대한내과학회 2011 대한내과학회지 Vol.81 No.4
폐흡충증은 덜 조리된 민물게나 가재에 있는 폐흡충증의 피낭 유충을 섭취하여 생기는 기생충 질환이다. 이는 감소하는 경향이지만 한국과 일본 등 유행하는 지역에서는 여전히 폐와 흉막 질환을 일으키는 중요한 원인으로 고려되어야 한다. 그리고 흔하지는 않지만 뇌, 척수, 복강 및 골반 장기나 피하조직에 이소성 병소를 유발할 수 있다. 저자들은 흉막염을 동반한 폐결핵과 별개의 질환으로서 병발한 유방 농양이라고 오인했다가 이소성 유방 농양과 흉막염을 동반한 폐흡충증으로 진단된 증례를 보고한다. Paragonimiasis is an infectious disease caused by consumption of raw or improperly cooked freshwater crab or crayfish contaminated with Paragonimus metacercariae. The incidence of the disease has markedly decreased, but it is still a lung disease that requires a differential diagnosis in endemic areas such as Korea and Japan. It is commonly found in the lung but has also been found as extrapulmonary infestations, such as cerebral, spinal, subcutaneous, abdominal, urinary, and gynecological infestations. We report a rare case of ectopic paragonimiasis involving the breast with pleural effusion that was initially misdiagnosed as tuberculous pleurisy and a breast abscess. (Korean J Med 2011;81:502-507)
김영욱 ( Young Wook Kim ),김주상 ( Ju Sang Kim ),안중현 ( Joong Hyun Ahn ),유지현 ( Ji Hyun Yu ),유진석 ( Jin Sok Yu ),전한희 ( Han Hee Chung ) 대한결핵 및 호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.72 No.1
We observed a very rare case of primary lung cancer producing alpha-fetoprotein (AFP). A 70-year-old male with a history of smoking 50 packs per year was diagnosed with large cell carcinoma of the lung. The clinical stage was T2bN3M0 (IIIB), and serum AFP was 23,247 ng/mL. There was no evidence of metastasis to the liver, scrotum or other organs. While undergoing chemotherapy for 1 year, as the cancer progressed the AFP value steadily increased. The patient died of respiratory failure due to pneumonia 12 months after being diagnosed with lung cancer.
이정은,함효주,이관용,노지웅,유진석,정우백 이화여자대학교 의과학연구소 2014 EMJ (Ewha medical journal) Vol.37 No.2
Early repolarization is a common electrocardiographic (ECG) feature found in young adults, men and athletes, and has been considered to be a benign feature for the last several decades. But recent studies suggest that early repolarization may be related to idiopathic ventricular fibrillation and sudden cardiac death. We report a young man, 35 years old, who had life threatening ventricular fibrillation and sudden cardiac arrest. He was evaluated for cardiac causes of ventricular fibrillation. There was no explanation other than that his ECG showed an early repolarization pattern so we treated him with implantable cardioverter defibrillator. Thus, we suggest that early repolarization may be related with life threatening ventricular arrhythmia.