http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 유용신(Yong Sin You) (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
부인암에서의 Telomerase 활성도와 자궁경부암 조직에서의 HPV E6 의 발현과 Telomerase 활성도의 상관관계
유용신(Yong Sin You),이선경(Seon Kyung Lee),김승보(Seung Bo Kim),지성길(Sung Gil Chi) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.8
N/A Object : In this study, to evaluate the putative role of telomerase in gynecologic malignancies (cervical ca, ovarian ca, endometrial ca), we measured telomerase activity in malignant gynecologic tumor tissues and normal tussues, and compared it with prognostic factors in cervical cancer. To evaluate the correlation of telomerase activity and human papillomavirus (HPV) infection in cervical cancer, the analysis of HPV E6 gene was performed. Method : Specimens were obtained from 51 women who underwent gynecologic radical operation and 13 normal tissues (from December 1995 to December 1996) in the Department of Obstetrics and Gynecology, Kyung-Hee Univ. Medical Center. With Telomerase PCR ELISA (Boehring Mannheim), modified TRAP (Telomere Repeat Amplication Protocol), we examined telomerase activity of 32 cervical carcinomas, 11 ovarian carcinomas, 8 endometrial carcinomas, 5 normal cervical tissues, 4 normal ovarian tissues and 4 normal endometrial tissues. The analysis of HPV E6 gene was performed by PCR amplication. We compared the abnormally high telomerase activity with prognostic factors, also compared the telomerase activity with the expression of HPV E6 gene in cervical cancer tissues. Result : We detected the abnormally high telomerase activity in all cervical carcinomas, 10 of 11 (90.9%) ovarian carcinomas, 6 of 8 (75.0%) endometrial carcinomas, but couldn't detect in each normal tissues. There was statistically no significant difference of telomerase activity levels according to age, clinical stage, pathology, differentiation, LN involvement, depth of invasion and tumor size except lymphovascular space invasion in cervical carcinomas (p<0.05). According to the analysis of HPV E6 gene, 29 of 32 (90.6%) in 32 cervical cancer tissues showed HPV E6 positivity. So it was considered that telomerase activation was closely related with the expression of HPV E6 gene. Conclusion : Telomerase activation is associated with immortalization or malignant transformation of gynecologic cancers. The expression of HPV E6 gene is considered to activate telomerase in cervical cancer.
-
신형성 부전 및 자궁 내막증을 수반한 흔적 자궁각 1 예
이선경,김승보,김범수,허주엽,유용신,진규섭 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.4
일측 신장 발육 부전 및 자궁 내막증이 동반된 비교통성 자궁각이 동반된 단각 자궁은 뮬러관 기형의 드문 형태이다. 이 기형은 젊은 연령층에서 생리통, 복통, 골반종괴 등의 증상이 있는 경우는 수술을 통해 치료해야 된다. 본 경희대학교 산부인과에서 보고된 바가 없는 우측 신형성 부전과 골반 내막증을 나타내는 비교통성 흔적 자궁각을 동반한 단각 자궁 1예를 치험하였기에 문헌 고찰과 함께 보고하는 바이다. Congenital M llerian anomalies of uterus are so infrequently encountered and endometriosis, primary infertility, hematometra, and urinary tract anomalies are claimed to be common complaints in women with unicornuate uterus. We report one case of rudimentary horn associated with agenesis of right kidney and pelvic endometriosis which is presented with brief review of literature about anomaly of the female genital tract.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
