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용정식 세계기독교통일신령협회 2004 統一世界 Vol.- No.6
2004년 3월 9일부터 3월 11일까지 세계평화초종교초국가연합(IIFWP)과 사모아 정부의 공동주관 하에 사모아의 수도 아피아에서 세계평화의회(IIPC) 오세아니아 지부 창설대회를 가졌다.
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Bacillus sp . E1 의 cyclodextrin 생산효소 유전자 분리 및 구명
용정식,최진남,박성순,박천석,박관화,최양도 ( Jeongsik Yong,Jin Nam Choi,Sung Soon Park,Cheon Seok Park,Kwan Hwa Park,Yang Do Choi ) 한국응용생명화학회 1997 Applied Biological Chemistry (Appl Biol Chem) Vol.40 No.6
To isolate a gene for cyclodextrin glycosyltransferase (CGTase) from alkalophilic Bacillus sp. El, polymerase chain reaction (PCR) amplification was carried out. Direct molecular cloning of 1.2 kbp fragment and partial nucleotide sequence analysis of the PCR amplified clone, pH12, showed close homology with CGTases from Bacillus species. To investigate the genomic structure of the gene, Southern blot analysis of genomic DNA was carried out with the clone pH12 as a molecular probe. It showed that 5.3 kbp XbaI fragment was hybridized with the probe pH12. To isolate a genomic clone, genomic DNA library was constructed and a genomic clone for CGTase, pCGTEl, was isolated. Nucleotide sequence analysis of the clone pCGTEl revealed that BCGTEl contained 2,109 bp open reading frame encoding a polypeptide of 703 amino acids and showed over 94.3% amino acid sequence homology with CGTase of β-cyclodextrin producer, Bacillus sp. KC201.
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Alternative Polyadenylation in Human Diseases
장재웅,예신성,용정식 대한내분비학회 2017 Endocrinology and metabolism Vol.32 No.4
Varying length of messenger RNA (mRNA) 3’-untranslated region is generated by alternating the usage of polyadenylation sites during pre-mRNA processing. It is prevalent through all eukaryotes and has emerged as a key mechanism for controlling gene expression. Alternative polyadenylation (APA) plays an important role for cell growth, proliferation, and differentiation. In this review, we discuss the functions of APA related with various physiological conditions including cellular metabolism, mRNA processing, and protein diversity in a variety of disease models. We also discuss the molecular mechanisms underlying APA regulation, such as variations in the concentration of mRNA processing factors and RNA-binding proteins, as well as global transcriptome changes under cellular signaling pathway.
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mTOR-coordinated Post-Transcriptional Gene Regulations: from Fundamental to Pathogenic Insights
Hsin-Sung Yeh,용정식 한국지질동맥경화학회 2020 지질·동맥경화학회지 Vol.9 No.1
Post-transcriptional regulations of mRNA transcripts such as alternative splicing and alternative polyadenylation can affect the expression of genes without changing the transcript levels. Recent studies have demonstrated that these post-transcriptional events can have significant physiological impacts on various biological systems and play important roles in the pathogenesis of a number of diseases, including cancers. Nevertheless, how cellular signaling pathways control these post-transcriptional processes in cells are not very well explored in the field yet. The mammalian target of rapamycin complex 1 (mTORC1) pathway plays a key role in sensing cellular nutrient and energy status and regulating the proliferation and growth of cells by controlling various anabolic and catabolic processes. Dysregulation of mTORC1 pathway can tip the metabolic balance of cells and is associated with a number of pathological conditions, including various types of cancers, diabetes, and cardiovascular diseases. Numerous reports have shown that mTORC1 controls its downstream pathways through translational and/or transcriptional regulation of the expression of key downstream effectors. And, recent studies have also shown that mTORC1 can control downstream pathways via post-transcriptional regulations. In this review, we will discuss the roles of post-transcriptional processes in gene expression regulations and how mTORC1-mediated post-transcriptional regulations contribute to cellular physiological changes. We highlight post-transcriptional regulation as an additional layer of gene expression control by mTORC1 to steer cellular biology. These emphasize the importance of studying post-transcriptional events in transcriptome datasets for gaining a fuller understanding of gene expression regulations in the biological systems of interest.
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