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      저자 : 어수택(S . T . Uh) (검색결과 1 건)
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        폐암과 폐결핵환자의 기관지폐포 세척액의 면역글로불린의 동향

        안상용(S . Y . Ahn),김인호(I . H . Kim),양동호(D . H . Yang),어수택(S . T . Uh),김태준(T . J . Kim),박춘식(C . S . Park) 대한내과학회 1986 대한내과학회지 Vol.30 No.6

        N/A The immune status changes in patients with lung cancer, but there is controversy about the degree and mechanism of changes in local humoral immune response. To evaluate 1) that the local immune response of lung cancer(Ca) is different from that of benign lung disease and 2) how the local immune response changes according to the extent of lung cancer. We measured immunoglobulin G.A.M. level in bronchoalveolar lavage(BAL) fluid of 25 patients with lung cancer and 16 patients with pulmonary tuberculosis(Tbc) 1) There was no difference in the concentration of serum IgG.A.M. between lung Ca and pulmonary Tbc. 2) In the BAL fluid, IgA concentration of lung Ca was higher than that of pulmonary Tbc(p<0.05), IgA concentration of lung Ca stage Ⅲ was higher than that of lung Ca stage I, Ⅱ (p<0.05) and lgM concentration of lung Ca stage, I , Ⅱ was higher than that of stage Ⅲ(p<0.05) 3) In the ratio of Ig to Albumin in BAL fluid. IgG and IgM of lung Ca was higher that those of pulmonary Tbc(p<0.05) and IgA of lung Ca stage g was higher than that of stage I, Ⅱ(p< 0.05) and IgM of lung Ca stage I, Ⅱ was higher than that of stage Ⅲ(p<0.05) 4) In the ratio of Ig to albumin-ratio of BAL to serum[(Ig/Alb) BAL/(Ig/Alb) Serum], IgA, M,G. of lung cancer and pulmonary Tbc were above l.0 but those of lung Ca was higher that those of pulmonary Tbc and IgM of lung Ca-stage I, Ⅱ was higher than that of lung Ca stage Ⅲ. In conclusion, local immune response of lung Ca is higher than that of pulmonary Tbc and the more extensive is the lesion of lung Ca, the higher is the local response of IgA and the less is the local response of IgM.

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