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RISS 인기검색어
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- 저자 : 심민철 ( Min Chul Shim ) (검색결과 73 건)
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Metal Injection Molding 공정으로 제조된 IN 713C 합금의 고온 기계적 특성
심민철 ( Min Chul Shim ),김규식 ( Kyu Sik Kim ),조규상 ( Kyu Sang Cho ),김지식 ( Ji Sik Kim ),이기안 ( Kee Ahn Lee ) 대한금속재료학회(구 대한금속학회) 2014 대한금속·재료학회지 Vol.52 No.5
We fabricated the IN 713C alloy by a metal injection molding (MIM) process and investigated the high temperature tensile properties. The microstructure of the MIMed IN 713C alloy mainly consisted of γ, γ′ and carbides. 0.98% (area fraction) of the pores was observed near the surface of the specimen, whereas 0.27% of the pores were located in the interior of the specimens. Tensile tests were conducted from room temperature to 900℃. The result of the tensile tests showed that this alloy had similar or somewhat higher strengths (YS: 734 MPa, UTS: 968 MPa, elongation: 7.16% at room temperature) from RT to 700℃ than those of cast IN 713C alloys. Above 700℃, however, strengths decreased rapidly with an increasing temperature (lower than those of cast IN 713C). The observation results of fractography revealed that the tensile fracture of the MIMed IN 713C alloy started near the surface defects and then the initial crack pro-pagated along the inter-particle region where oxides were observed regardless of deformation temperatures.
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간장 ( 肝臟 ) 및 담도 ( 膽道 ) : Hepatic Vascular Exclusion시 저온 관류가 혈역학 및 간 세포기능에 미치는 영향
김홍진(Hong Jin Kim),심민철(Min Chul Shim),권굉보(Koing Bo Kwun),김욱동(Wook Dong Kim) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.1
Intraoperative bleeding is the main risk during liver resection. Hepatic inflow occlusion is one of the methods that can be used to reduce this risk. Hepatic Vascular Exclusion (HVE) associates portal triad cross clamping and occlusion of the inferior vena cava below and above the liver and it completely isolates the liver and retrohepatic vena cava from the rest of the circulation. The hepatic vascular exclusion results in liver i hemia. To prevent ischemic liver injury, cold perfusion has been applied in almost all transplantation. However, there are some controversies about the hypothermic perfusion to protect ischemic injury. So, the author conducted an experiment to observe hepatic functional impairment and hemodynamic alteration during HVE and compared with that of cold saline perfusion (flushing 4'C Ringers lactate solution through the portal vein with the rate of 50 ml/min) group. We divided forteen mongoreal dogs into control (n = 7) and experiment group (n = 7) and observed mean arterial pressure, liver enzymes (aspartate aminotransferase, alanine aminotransferase, lactic dehydrogenase) and arterial ketone body ratio (KBR) during HVE and after removal of HVE. The result are as follows; The mean arterial pressure decreased significantly in the both group after 30 min HVE, but recovered to relatively normal values at 30 min and 60 min after declamping. Aspartate aminotransferase increased during and after the HVE peroid in both groups, but there is no difference between two groups. Alanine aminotransferase increased during and after the HVE period in both group, but a lesser increase was observed in the experimental group. (p<0.01) Lactic dehydrogenase increased during and after the HVE period in both group, a lesser increase was observed in the experimental group. The arterial KBR decreased markedly during the HVE period in both groups but recovered to preoperative values at 30 min and 60 min after declamping. There is no difference between two groups. From these results, it is suggested that HVE is a safe and useful technique in major hepatic resection and hypothermic perfusion during HVE may be beneficial to prevent warm ischemic damage to hepatocyte but further studies willl be anticipated.
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간장 ( 肝臟 ) , 담도 ( 膽道 ) 및 췌장 ( 膵臟 ) : 약제에 의한 간장의 허혈 및 재관류 손상의 방지
김홍진(Hong Jin Kim),심민철(Min Chul Shim),권굉보(Koing Bo Kwun),박동일(Dong Il Park),노진우(Jin Woo Roh) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.3
Several drugs known to be vasodilators and/or membrane stabilizers were studied to evaluate whether these would have protective effects against experimental eschemia-reperfusion induced liver injury in rats. The aninmals were divided into six groups-control, treatment with pentoxifylline, aprotinin, FDP, verapamil, and sham operation. Drugs were administered systemically through IVC 5 minutes before induction of ischemia. The hepatic arterial and portal venous blood supply to the left lateral and median lobes of the liver was interrupted with an surgical clip for 90 minutes to induce hepatic ischemia, and after then the clip was removed for reperfusion. The arterial blood SGOT, SGPT, ALP, LDH, and hepatic MDA were measured before and 90 minutes after ischemia, and at the end of 60 minutes reperfusion. The control group showed sharp elevation of the all liver enzymes following both hepatic ischemia and reperfusion. However the treated groups with pentoxifylline, aprotinin, FDP, and verapamil demonstrated significantly lower level of liver enzymes compare with the values of the control group. Verapamil thought to be most effective in protection of liver from ischemia- reperfusion injury. The hepatic MDA l evel decreased during ischemia-reperfusion procedures, and showed no significant difference between control and treatment groups.
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간장 ( 肝腸 ) 및 담도 ( 膽道 ) : 간절제를 겸한 간문부 담관암 수술
김홍진(Hong Jin Kim),심민철(Min Chul Shim),권굉보(Koing Bo Kwun),이상춘(Sang Choon Lee),박동일(Dong Il Park) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.3
N/A Proximal bile duct cancer arises in hepatic duct at its bifurcation within the porta hepatis and is associated with the lowest rates of resectability and poorest survival among tumors in all locations in the duct. Low resectability rates are the results of close proximity to the portal vein and its branches, and the parenchyma of the liver. Recently, because of the development of newer diagnostic imaging modalities, such as endoscopic retrograde cholangiopancreatography, percutaneous transhepatic cholangiography, ultrasonography, and computed tomography, some of the patients can get an early diagnosis and a successful resection. Recently, it have been reported that agressive resection for cure is the procedure of choice in selected patients with proximal bile duct cancer, and offers not only the best possibility of prolonged survival but also even cure and the best quality of life. We hve experienced 8 cases of successful radical resection including hepatectomy for proximal bile duct cancer.
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간절제후의 IL-1β , IL-6 및 TNF-α의 변화
김홍진 ( Hong Jin Kim ),심민철 ( Min Chul Shim ),윤성수 ( Sung Su Yun ),전용성 ( Yong Sung Jeon ),권굉보 ( Kyung Bo Kwun ) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.2
Background/Aims: The liver is a central organ in metabolic and irnmune homeostasis under normal and pathologic condition and its funtion is directed by classic homiones and a network of cytokine mediators. Because the liver has a strong potentiol for regeneration, clarifying its mechanism is a matter of great interest. Although many studies on cytokines are being conducted, its clinical significance in hepatectomy still remains unclear. The aim of this study is to clarify the changes of serum cytokines and to investigate the possible regulation of the cytokine release in hepatectomy. Methods: We studied 55 patients who had underwent hepatectomy in the department of surgery at Yeungnam University Hospital between Septernber 1992 and July 1994. Serum levels of IL-1 0, IL-6, TNF- a were measured before operation and on the postoperative day(POD) 1, 3, 5 and 7. Then those were compared between patients with major resection(more than 2 segments) and minor resection, between patients with cirrhosis and those without cirrhosis, and between patients with recovered without complication and patients recovered with comp]ication or inortality. Results: ln the recovery group, the levels of serum IL-10 reached peak levels at POD # 1 and then gradually decreased, the levels of the serum IL-6 reached peak levels at POD 0 l and re- elevated at POD # 5, but there was no significant change in the serial levels of the serum TNF- a. No significant difference in the serial levels of cytokines(IL-] 0, IL-6, TNF- a ) was found hetween the patients with cirrhosis and those without cirrhosis and between the major resection and minor resection. The levels of cytokines in the complication R mortality group were higher than those of the recovery group. Conclusions; The levels of IL-I 3, IL-6 reached peak level at POD # 1 and gradually decreased to normal levels at POD 0 7 in the recovery group. In the complication & mortality group, the levels of cytokines were higher than those of the recovery group. (Korean J Gastroenterol 1997;29:192-198)
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간장 ( 肝臟 ) , 담도 ( 膽道 ) 및 췌장 ( 膵臟 ) : 단순 담낭 절제술 후 배액술의 필요성
김홍진(Hong Jin Kim),심민철(Min Chul Shim),권굉보(Koing Bo Kwun),노진우(Jin Woo Roh),김재황(Jae Hwang Kim) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.3
A retrospective review is undertaken to evaluate the effects of drainage versus nondrainage of the gallbladder bed after elective cholecystectomy. Ninety one charts of patients who underwent elective cholecystectomy without choledochotomy were reviewed. Patient selection was based upon following criteria: 1) No evidence of empyema, pericholecystic abscess or cholangitis 2) No bleeding or leakage of bile from the bed of the gallbladder after cholecystectomy 3) Lack of exploration of the common bile duct. Two groups were analyzed. Those who had postoperative drainage of the subhepatic space and those who didn't have drainage. The results are as follows. Postoperative length of hospital stay was longer in the drainage group (p<0.05). The average days of hospital stay were 7.75 (+- 1.20) in nondrainage group and 8.16 (+- 1.21) in drainage group. Maximum postoperative temperature elevation was higher in the drainage group (p<0.05). The average maximum postoperative temperature were 37.20 (+- 0.33)C in nondrainage group and 37.94 (+- 0.42)C in drainage group. There was no significant difference in the duration of the postoperative fever between the drainage and nondrainage group. The average druation of the postoperative fever were 1.91 (+- 1.44) days in the nondrainage group and 2.27 (+- 1.47) days in the drainage group. There was no significant difference in the dose of the postoperative analgesics between the drainage and nondrainage group. The average dose of the postoperative analgesics were 4.45 (+- l. 47) in the nondrainage group and 4.98 (+- 2.12) in the drainage group. There was no significant difference in the complication rate between the drainage and nondrainage group. It is concluded that routine drainage of the subhepatic space after elective cholecystectomy without choledochotomy is unnecessary and contributes to increased length of postoperative hospotal stay and a higher rate of patients discomfort.
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