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Advances in vitiligo research and therapeutic suggestions
신정현 ( Jeonghyun Shin ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Vitiligo is a relatively common skin disease, and is an acquired pigmentary disorder characterized by areas of depigmented skin resulting from loss of epidermal melanocytes. The prevalence of this disease varies from 0.2% to 1% in various global populations without sex predilection. Despite recent studies that have contributed new knowledge about the disease, understanding its pathogenesis remains a major challenge. Although several hypotheses have been proposed, an autoimmune response against melanocytes remains the leading candidate. Accordingly, evidences of genetic defects in immune regulation and melanocytes components are increasingly reported. And oxidative stress as the primary intracellular signal for melanocyte degeneration may be the initial event that leads to the activation of the anti-melanocyte immune responses in patients with genetic predisposition to autoimmunity. Recent advances in the understanding of the pathogenesis of vitiligo suggest new therapeutic options such as Janus kinase inhibitors, activated low-dose cytokines-based therapy, miRNA inhibitor, etc. in the near future.
황혜원 ( Hye Won Hwang ),이선복 ( Seon Bok Lee ),허지혜 ( Ji Hye Heo ),신정현 ( Jeonghyun Shin ),최광성 ( Gwang Seong Choi ),변지원 ( Ji Won Byun ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.2
Syringoid eccrine carcinoma (SEC) is a rare cutaneous malignant tumor thought to be derived from eccrine sweat glands. It is usually present in the scalp and face and often occurs in the fourth to seventh decades of life. A 76-year-old female patient visited our department with a 3-year history of a lesion showing a 5×4 cm-sized erythematous firm plaque with ulceration on her right shoulder. Histological findings revealed a tumor consisting of numerous proliferating tubular structures with two layers of basaloid cells with cellular atypia. Some ductal structures showed a tadpole appearance. Based on these findings, the final diagnosis was SEC. The patient was treated with slow Mohs micrographic surgery and a full-thickness skin graft and did not show any recurrence during the follow-up period of 6 months. Herein, we report a very rare case of a 76-year-old woman diagnosed with SEC that developed on the right shoulder. (Korean J Dermatol 2021;59(2):136∼139)
성인발병 Still병의 피부 소견에 대한 임상 및 조직학적 고찰
한성협 ( Sung Hyub Han ),최광성 ( Gwang Seong Choi ),신정현 ( Jeonghyun Shin ) 대한피부과학회 2010 大韓皮膚科學會誌 Vol.48 No.4
Background: Adult-onset Still`s disease (AOSD), one of the causes of fever of unknown origin, is accompanied by skin rash. This is the reason why the clinical significance of skin lesions has been of interest. However, its skin manifestations and the histopathological findings are not clearly documented. Objective: This study aimed to identify characteristic clinical and histopathological features of skin manifestation of AOSD. Methods: We evaluated the medical records and histopathologic slides of five patients who had been diagnosed with AOSD in the rheumatology department and referred to our department between 1996 and 2009. Results: An asymptomatic evanescent salmon colored macular rash was seen in three patients (60%). A persistent brown plaque was seen in two patients (40%). Histopathologically, superficial perivascular infiltrates of neutrophils and lymphocytes were observed in all patients (100%) and necrotic keratinocytes were observed in the upper epidermis in three patients (60%). Conclusion: In addition to typical Still`s rash, atypical cutaneous findings such as persistent plaque lesions were found in AOSD patients. The results of this study may help clinicians to diagnose this rare disease more easily. (Korean J Dermatol 2010;48(4):283~289)
연골모양 한관종의 발생 위치에 따른 임상 및 병리조직학적 연구
이선복 ( Seon Bok Lee ),염승돈 ( Seung Dohn Yeom ),신정현 ( Jeonghyun Shin ),최광성 ( Gwang Seong Choi ),변지원 ( Ji Won Byun ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.3
Background: Chondroid syringoma (CS) is an uncommon benign neoplasm of the head and neck seen in middle-aged to elderly individuals. Histopathologically, chondroid syringoma displays nests of cuboidal epithelial cells embedded in a matrix. It is classified as both a tubular branching lumina type and a small tubular lumina type and may exhibit a wide range of differentiation and metaplastic changes in the epithelial and stromal components. Objective: To investigate the correlation between the clinical and histopathologic features of chondroid syringoma. Methods: We evaluated the electronic medical records, clinical photographs, and histopathological slides of 17 patients diagnosed with chondroid syringoma. Results: CS in the terminal hair skin tended to have larger lesions (p=0.036). Tumors in terminal hair skin demonstrated significantly more follicular differentiation (p=0.044) than those in the vellus hair skin. CS arising on the scalp tended to have more osseous metaplasia compared to those arising on non-scalp areas (p=0.022). Conclusion: This study showed that the clinical and histopathological features of CS can differ depending on its location. (Korean J Dermatol 2021;59(3):188∼195)
안드로겐성 탈모증 환자에서 폴리감마 글루탐산 하이드로겔 나노입자에 포집한 혼합복합발효추출물 도포제의 임상시험
이선복 ( Seon Bok Lee ),황혜원 ( Hye Won Hwang ),허지혜 ( Ji Hye Heo ),이시협 ( Si Hyub Lee ),신현태 ( Hyun-tae Shin ),변지원 ( Ji Won Byun ),신정현 ( Jeonghyun Shin ),최광성 ( Gwang Seong Choi ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.2
Background: Androgenetic alopecia (AGA) is the most common cause of hair loss in adults. Topical application of the fermented extract of medicinal plants promoted hair growth through stimulation of the telogen to anagen transition in a mouse model. However, controlled studies are necessary to evaluate the efficacy of the topical application of the fermented extract solution in humans. Objective: We aimed to assess the efficacy and safety of topical poly-gamma glutamic acid hydrogel nanoparticlebased fermented extract of a medicinal plant solution (PGA solution) in terms of the clinical improvements in patients with AGA. Methods: This 24-week, randomized, double-blinded, placebo-controlled, single-center clinical trial enrolled 50 patients with AGA (36 men and 14 women); the participants were treated with either PGA solution or placebo twice daily for 24 weeks. Efficacy was evaluated by a phototrichogram (total hair count per 1 cm<sup>2</sup>), patient’s subjective assessments, and investigator’s subjective assessments of clinical improvements in overall hair regrowth. Any adverse reactions were reported during the study. Results: At week 24, compared with baseline, the PGA solution group showed a significantly increased hair density compared to the placebo group (7.24±2.52/cm<sup>2</sup> vs. 1.53±1.39/cm<sup>2</sup>, p<0.0001). The average hair density after 24 weeks was 129.90±23.04/cm<sup>2</sup> and 115.32±20.35/cm<sup>2</sup> in the PGA solution group and the placebo group, respectively. There was no adverse reaction over the 24-week period. Conclusion: PGA solution may provide a safe and effective adjunctive treatment for patients with AGA. (Korean J Dermatol 2021;59(2):81∼87)
이경주 ( Kyung-ju Lee ),정준형 ( Jun Hyeong Jeong ),이재원 ( Jae Won Lee ),황혜원 ( Hyewon Hwang ),신현태 ( Hyun-tae Shin ),변지원 ( Ji Won Byun ),최광성 ( Gwang Seong Choi ),신정현 ( Jeonghyun Shin ) 대한피부과학회 2024 대한피부과학회지 Vol.62 No.6
Background: Vitiligo, which is characterized by depigmented patches on the skin, poses challenges in achieving lasting repigmentation after treatment. Identifying factors contributing to vitiligo recurrence is vital for effective management; however, there is a significant knowledge gap regarding post-treatment recurrence factors in patients with vitiligo. Objective: We aimed to investigate the factors associated with recurrence in patients with non-segmental vitiligo. Methods: We retrospectively analyzed patient’s medical records from 2000 to 2023, and defined a “cure group” with cosmetically satisfactorily repigmentation maintained for at least 6 months. This group was further divided into recurrence and non-recurrence groups. We analyzed the clinical characteristics and various factors related to treatment. Furthermore, we explored the cure and recurrence rates based on the location of vitiligo, and performed a survival analysis for recurrence with or without maintenance therapy. Results: Of 70 cured patients, 19 relapsed. Maintenance treatment was the most significant factor affecting vitiligo recurrence (p<0.0001, odds ratio=0.029). There were no statistically significant differences in initial age, sex, disease duration, sites, subtype, treatment duration, treatment modality, and comorbidities. After 100 months, 87.3% of the patients in the maintenance therapy group remained recurrence-free, while only 20% of the non-maintenance therapy group did not experience recurrence. Head and neck lesions had the highest cure rates, whereas lower limb lesions showed higher recurrence rates. Approximately 63.2% of recurrences occurred at the original site, while 31.6% occurred outside the original site. Conclusion: The absence of maintenance therapy was the most important factor associated with the recurrence of nonsegmental vitiligo. (Korean J Dermatol 2024;62(6):327∼335)
윤희성 ( Hee Seong Yoon ),이시협 ( Si Hyub Lee ),염승돈 ( Seung Dohn Yeom ),한지영 ( Jeeyoung Han ),신정현 ( Jeonghyun Shin ),최광성 ( Gwang Seong Choi ),변지원 ( Ji Won Byun ) 대한피부과학회 2018 대한피부과학회지 Vol.56 No.9
Congenital hemangioma (CH) is a fully formed benign vascular tumor at the time of birth and do not proliferate in postnatal life. CH must be differentiated from infantile hemangioma. CH has three subtypes that are recognized based on their natural history: Rapidly involuting congenital hemangioma (RICH), non-involuting congenital hemangioma (NICH), and partially involuting congenital hemangioma (PICH). It is important to distinguish RICH from NICH because RICH spontaneously regresses but NICH does not. Herein, we report two patients diagnosed with RICH and NICH, respectively. We presented the clinical features as well as ultrasonographic and histologic findings to distinguish congenital from infantile hemangioma. (Korean J Dermatol 2018;56(9):556∼560)