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바이오 플로터를 이용한 생체 조직 재생용 담체 제작과 특성분석
손준곤(Son JoonGon),김지웅(Kim JiWoong),박수아(Park SuA),김완두(Kim WanDoo) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.5
Scaffold using the chemical method of salt-leaching has the some pore distribution and high porosity. However, mechanical strength is not strong and another serious shortcoming is that pores are not interconnected to each others in this structure. it limits the penetration depth that it blocks the supply route of nutritive and oxygen so that the cells are not able to proliferate any more. In this paper, design-based scaffolds that have enhanced mechanical property were fabricated by bioplotting method, which pore size is suitable for cell culture and well-interconnected. Measurement and analysis for precision of 3D scaffold by bio-plotter system were performed by microscopy.
손준곤(JoonGon Son),박수아(SuA Park),김근형(GeunHyung Kim),김완두(WanDoo Kim) 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.10
Various mechanical techniques have been used to fabricate biomedical scaffolds used for soft and hard tissue regeneration Scaffolds should have bio-degradability and bio-compatibility, which are temporary support for cell growth to afford to cell adhesion and consist of a defined structure and can be built with customized shape by CAD system This versatility in preparing scaffolds gives us the opportunity to use the rapid prototyping device to fabricate scaffolds and Bio-plotter draws and deposits each layer of scaffolds with various materials. From a mechanical point of view, scaffolds should match the biomechanical properties of the tissue or organ to be replaced. This kind of polymer material is much affected by processing conditions which can change many mechanical properties of scaffold We have examined the mechanical properties of PCL scaffold fabricated by various processing conditions of bio-plotter and found the optimized conditions for constructing the layered scaffolds.